Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2

We previously reported that transgenic (Tg) mice expressing human angiotensin-converting enzyme 2 (hACE2), the receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), were highly susceptible to SARS-CoV infection, which resulted in the development of disease of various severity and ev...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of virology Vol. 83; no. 11; p. 5451
Main Authors:	Yoshikawa, Naoko, Yoshikawa, Tomoki, Hill, Terence, Huang, Cheng, Watts, Douglas M, Makino, Shinji, Milligan, Gregg, Chan, Tehsheng, Peters, Clarence J, Tseng, Chien-Te K
Format:	Journal Article
Language:	English
Published:	United States 01.06.2009
Subjects:	Angiotensin-Converting Enzyme 2 Animals Brain Diseases - virology Cell Proliferation - drug effects Concanavalin A - pharmacology Cytokines - immunology Gene Expression Regulation, Enzymologic Genetic Predisposition to Disease - genetics Humans Kinetics Lung Diseases - virology Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - immunology Mice Mice, Transgenic Organ Specificity Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Severe Acute Respiratory Syndrome - immunology Severe Acute Respiratory Syndrome - metabolism Severe Acute Respiratory Syndrome - pathology Severe Acute Respiratory Syndrome - virology Severe acute respiratory syndrome-related coronavirus - immunology Spleen - cytology Spleen - drug effects Spleen - immunology Virus Replication
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!