Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies

Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell therapies. Acute neurologic signs and/or symptoms occur in a significant proportion of patients treated with CD19-directed chimeric antigen receptor-T cells for B-cell malignancies. Clinical manifestations incl...

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Vydáno v:	CNS drugs Ročník 32; číslo 12; s. 1091 - 1101
Hlavní autoři:	Gust, Juliane, Taraseviciute, Agne, Turtle, Cameron J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cham Springer International Publishing 01.12.2018 Springer Nature B.V
Témata:	Animal models Antigens Antigens, CD19 - metabolism Arthritis Blood-brain barrier Brain cancer CD19 antigen Cell activation Cell therapy Cerebrospinal fluid Chimeric antigen receptors Clinical trials Corticosteroids Cytokines Cytokines - blood Cytokines - cerebrospinal fluid Edema FDA approval Headache Humans Immunologic Factors - therapeutic use Immunotherapy Immunotherapy, Adoptive - methods Interleukin 6 Leading Article Leukemia Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Medicine Medicine & Public Health Multiple myeloma Neurology Neurosciences Neurotoxicity Neurotoxicity Syndromes - epidemiology Neurotoxicity Syndromes - immunology Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - therapy Pediatrics Pharmacotherapy Psychiatry Psychopharmacology Receptors, Antigen, T-Cell - metabolism Seizures Traumatic brain injury Young adults United States > US
ISSN:	1172-7047, 1179-1934, 1179-1934
On-line přístup:	Získat plný text
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