T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour cells especially sensitive to the agent being applied. Problems exist with the application of many agents as a result of damage to local tissues,...

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Vydané v:	Cell death & disease Ročník 9; číslo 11; s. 1089 - 10
Hlavní autori:	Herbert, Katharine J., Ashton, Thomas M., Prevo, Remko, Pirovano, Giacomo, Higgins, Geoff S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 24.10.2018 Springer Nature B.V
Predmet:	Animals Antibodies Biochemistry Biomarkers, Tumor - antagonists & inhibitors Biomarkers, Tumor - metabolism Biomedical and Life Sciences Cancer Cancer therapies Cell Biology Cell Culture Cell cycle Cell Line, Tumor Clinical trials Disease Models, Animal Drug Discovery - methods Gene expression Humans Immunology Indolizines - pharmacology Indolizines - therapeutic use Kinases Life Sciences Mice Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Protein kinase Quinolones - pharmacology Quinolones - therapeutic use Quinoxalines - pharmacology Quinoxalines - therapeutic use Review Review Article Thiophenes - pharmacology Thiophenes - therapeutic use Toxicity Treatment Outcome Treatment resistance Tumors
ISSN:	2041-4889, 2041-4889
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