Parameter estimation in biochemical pathways: a comparison of global optimization methods

Here we address the problem of parameter estimation (inverse problem) of nonlinear dynamic biochemical pathways. This problem is stated as a nonlinear programming (NLP) problem subject to nonlinear differential-algebraic constraints. These problems are known to be frequently ill-conditioned and mult...

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Bibliographic Details
Published in:	Genome research Vol. 13; no. 11; p. 2467
Main Authors:	Moles, Carmen G, Mendes, Pedro, Banga, Julio R
Format:	Journal Article
Language:	English
Published:	United States 01.11.2003
Subjects:	Algorithms Computational Biology - methods Computational Biology - statistics & numerical data Computer Simulation Evolution, Molecular Genetic Engineering - methods HIV Protease - chemistry HIV Protease - genetics HIV Protease - metabolism HIV Protease Inhibitors - chemistry Models, Chemical Molecular Biology - methods Molecular Biology - statistics & numerical data Nonlinear Dynamics Predictive Value of Tests Software - statistics & numerical data Stochastic Processes
ISSN:	1088-9051
Online Access:	Get more information
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