Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory li...

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Bibliographic Details
Published in:	Frontiers in cellular and infection microbiology Vol. 12; p. 881462
Main Authors:	Lucarelli, Ronald, Gorrochotegui-Escalante, Norma, Taddeo, Jessica, Buttaro, Bettina, Beld, Joris, Tam, Vincent
Format:	Journal Article
Language:	English
Published:	Lausanne Frontiers Media SA 04.07.2022 Frontiers Media S.A
Subjects:	Antibacterial activity Bacterial infections Cellular and Infection Microbiology Cytochrome P450 eicosanoid Eicosanoids Inflammation Influenza innate immunity lipidomic Lipids Macrophages Metabolites Mortality NF-κB protein Nuclear transport Phosphorylation Staphylococcus aureus Superinfection Toll-like receptors Transcription activation
ISSN:	2235-2988, 2235-2988
Online Access:	Get full text
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