Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects

Objectives The aim of this study was to assess the pharmacokinetics (PK) and safety/tolerability of siponimod in healthy subjects when coadministered with (1) the moderate cytochrome P450 (CYP) 2C9 and CYP3A inhibitor fluconazole (Study A), and (2) with three different CYP2C9 genotype variants (Stud...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 58; no. 3; pp. 349 - 361
Main Authors:	Gardin, Anne, Ufer, Mike, Legangneux, Eric, Rossato, Gianluca, Jin, Yi, Su, Zhenzhong, Pal, Parasar, Li, Wenkui, Shakeri-Nejad, Kasra
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.03.2019 Springer Nature B.V
Subjects:	Adolescent Adult Antifungal agents Azetidines - administration & dosage Azetidines - pharmacokinetics Benzyl Compounds - administration & dosage Benzyl Compounds - pharmacokinetics Clinical medicine Cytochrome Cytochrome P-450 CYP2C9 - drug effects Cytochrome P-450 CYP2C9 - metabolism Cytochrome P-450 CYP2C9 Inhibitors - administration & dosage Cytochrome P-450 CYP3A Inhibitors - administration & dosage Cytochrome P-450 CYP3A Inhibitors - therapeutic use Drug dosages Drug Interactions Drug Therapy, Combination - methods Enzymes Female Fluconazole - administration & dosage Genotype Genotype & phenotype Healthy Volunteers - statistics & numerical data Humans Internal Medicine Male Medical research Medicine Medicine & Public Health Metabolism Metabolites Middle Aged Multiple sclerosis Original Original Research Article Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Polymorphism, Genetic - genetics Sphingosine 1 Phosphate Receptor Modulators - administration & dosage Sphingosine 1 Phosphate Receptor Modulators - pharmacokinetics Studies Young Adult United States > US
ISSN:	0312-5963, 1179-1926, 1179-1926
Online Access:	Get full text
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