The mechanisms of action of metformin

Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic glucose production, ye...

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Bibliographic Details
Published in:	Diabetologia Vol. 60; no. 9; pp. 1577 - 1585
Main Authors:	Rena, Graham, Hardie, D. Grahame, Pearson, Ewan R.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017 Springer Nature B.V
Subjects:	AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Antidiabetics Biguanides - therapeutic use Blood glucose Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Electron transport Gastrointestinal tract Glucose Glucose metabolism Human Physiology Humans Hypoglycemic Agents - therapeutic use Internal Medicine Kinases Liver Medicine Medicine & Public Health Metabolic Diseases Metformin Metformin - therapeutic use Mitochondria Review AMPK Biguanide Diabetes Metformin Review
ISSN:	0012-186X, 1432-0428, 1432-0428
Online Access:	Get full text
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