Retinal and Optic Nerve Degeneration in Patients with Multiple Sclerosis Followed up for 5 Years

To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. Observational and longitudinal study. One hundred patients with relapsing-remit...

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Vydané v:	Ophthalmology (Rochester, Minn.) Ročník 124; číslo 5; s. 688
Hlavní autori:	Garcia-Martin, Elena, Ara, Jose R, Martin, Jesus, Almarcegui, Carmen, Dolz, Isabel, Vilades, Elisa, Gil-Arribas, Laura, Fernandez, Francisco J, Polo, Vicente, Larrosa, Jose M, Pablo, Luis E, Satue, Maria
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.05.2017
Predmet:	Adult Axons - pathology Disability Evaluation Disease Progression Female Follow-Up Studies Humans Male Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Multiple Sclerosis - rehabilitation Nerve Fibers - pathology Optic Atrophy - diagnosis Optic Atrophy - etiology Optic Atrophy - rehabilitation Optic Nerve - pathology Prognosis Quality of Life Retinal Degeneration - diagnosis Retinal Degeneration - etiology Retinal Degeneration - rehabilitation Retinal Ganglion Cells - pathology Retrospective Studies Time Factors Tomography, Optical Coherence - methods Visual Acuity
ISSN:	1549-4713, 1549-4713
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Abstract	To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. Observational and longitudinal study. One hundred patients with relapsing-remitting MS and 50 healthy controls. All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years. Visual acuity (Snellen chart), color vision (Ishihara pseudoisochromatic plates), visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (SLP), and visual evoked potentials. Expanded Disability Status Scale (EDSS) scores, disease duration, treatments, prior optic neuritis episodes, and quality of life (QOL; based on the 54-item Multiple Sclerosis Quality of Life Scale score). Optical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in visual acuity, color vision, or visual fields. Optical coherence tomography showed greater differences in the inferior and temporal RNFL thicknesses in both groups. In MS patients only, OCT revealed a moderate correlation between the increase in EDSS and temporal and superior RNFL thinning. Temporal RNFL thinning based on OCT results was correlated moderately with decreased QOL. Multiple sclerosis patients exhibit a progressive axonal loss in the optic nerve fiber layer. Retinal nerve fiber layer thinning based on OCT results is a useful marker for assessing MS progression and correlates with increased disability and reduced QOL.
AbstractList	To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration.PURPOSETo quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration.Observational and longitudinal study.DESIGNObservational and longitudinal study.One hundred patients with relapsing-remitting MS and 50 healthy controls.PARTICIPANTSOne hundred patients with relapsing-remitting MS and 50 healthy controls.All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years.METHODSAll participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years.Visual acuity (Snellen chart), color vision (Ishihara pseudoisochromatic plates), visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (SLP), and visual evoked potentials. Expanded Disability Status Scale (EDSS) scores, disease duration, treatments, prior optic neuritis episodes, and quality of life (QOL; based on the 54-item Multiple Sclerosis Quality of Life Scale score).MAIN OUTCOME MEASURESVisual acuity (Snellen chart), color vision (Ishihara pseudoisochromatic plates), visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (SLP), and visual evoked potentials. Expanded Disability Status Scale (EDSS) scores, disease duration, treatments, prior optic neuritis episodes, and quality of life (QOL; based on the 54-item Multiple Sclerosis Quality of Life Scale score).Optical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in visual acuity, color vision, or visual fields. Optical coherence tomography showed greater differences in the inferior and temporal RNFL thicknesses in both groups. In MS patients only, OCT revealed a moderate correlation between the increase in EDSS and temporal and superior RNFL thinning. Temporal RNFL thinning based on OCT results was correlated moderately with decreased QOL.RESULTSOptical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in visual acuity, color vision, or visual fields. Optical coherence tomography showed greater differences in the inferior and temporal RNFL thicknesses in both groups. In MS patients only, OCT revealed a moderate correlation between the increase in EDSS and temporal and superior RNFL thinning. Temporal RNFL thinning based on OCT results was correlated moderately with decreased QOL.Multiple sclerosis patients exhibit a progressive axonal loss in the optic nerve fiber layer. Retinal nerve fiber layer thinning based on OCT results is a useful marker for assessing MS progression and correlates with increased disability and reduced QOL.CONCLUSIONSMultiple sclerosis patients exhibit a progressive axonal loss in the optic nerve fiber layer. Retinal nerve fiber layer thinning based on OCT results is a useful marker for assessing MS progression and correlates with increased disability and reduced QOL. To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. Observational and longitudinal study. One hundred patients with relapsing-remitting MS and 50 healthy controls. All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years. Visual acuity (Snellen chart), color vision (Ishihara pseudoisochromatic plates), visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (SLP), and visual evoked potentials. Expanded Disability Status Scale (EDSS) scores, disease duration, treatments, prior optic neuritis episodes, and quality of life (QOL; based on the 54-item Multiple Sclerosis Quality of Life Scale score). Optical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in visual acuity, color vision, or visual fields. Optical coherence tomography showed greater differences in the inferior and temporal RNFL thicknesses in both groups. In MS patients only, OCT revealed a moderate correlation between the increase in EDSS and temporal and superior RNFL thinning. Temporal RNFL thinning based on OCT results was correlated moderately with decreased QOL. Multiple sclerosis patients exhibit a progressive axonal loss in the optic nerve fiber layer. Retinal nerve fiber layer thinning based on OCT results is a useful marker for assessing MS progression and correlates with increased disability and reduced QOL.
Author	Satue, Maria Pablo, Luis E Almarcegui, Carmen Fernandez, Francisco J Polo, Vicente Gil-Arribas, Laura Ara, Jose R Larrosa, Jose M Garcia-Martin, Elena Martin, Jesus Dolz, Isabel Vilades, Elisa
Author_xml	– sequence: 1 givenname: Elena surname: Garcia-Martin fullname: Garcia-Martin, Elena email: egmvivax@yahoo.com organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain. Electronic address: egmvivax@yahoo.com – sequence: 2 givenname: Jose R surname: Ara fullname: Ara, Jose R organization: Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain; Department of Neurology, Miguel Servet University Hospital, Zaragoza, Spain – sequence: 3 givenname: Jesus surname: Martin fullname: Martin, Jesus organization: Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain; Department of Neurology, Miguel Servet University Hospital, Zaragoza, Spain – sequence: 4 givenname: Carmen surname: Almarcegui fullname: Almarcegui, Carmen organization: Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain; Department of Neurophysiology, Miguel Servet University Hospital, Zaragoza, Spain – sequence: 5 givenname: Isabel surname: Dolz fullname: Dolz, Isabel organization: Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain; Department of Neurophysiology, Miguel Servet University Hospital, Zaragoza, Spain – sequence: 6 givenname: Elisa surname: Vilades fullname: Vilades, Elisa organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 7 givenname: Laura surname: Gil-Arribas fullname: Gil-Arribas, Laura organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 8 givenname: Francisco J surname: Fernandez fullname: Fernandez, Francisco J organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 9 givenname: Vicente surname: Polo fullname: Polo, Vicente organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 10 givenname: Jose M surname: Larrosa fullname: Larrosa, Jose M organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 11 givenname: Luis E surname: Pablo fullname: Pablo, Luis E organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain – sequence: 12 givenname: Maria surname: Satue fullname: Satue, Maria organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain; Aragon Institute for Health Research (Instituto de Investigación Sanitario [IIS] Aragon), University of Zaragoza, Zaragoza, Spain
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SubjectTerms	Adult Axons - pathology Disability Evaluation Disease Progression Female Follow-Up Studies Humans Male Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Multiple Sclerosis - rehabilitation Nerve Fibers - pathology Optic Atrophy - diagnosis Optic Atrophy - etiology Optic Atrophy - rehabilitation Optic Nerve - pathology Prognosis Quality of Life Retinal Degeneration - diagnosis Retinal Degeneration - etiology Retinal Degeneration - rehabilitation Retinal Ganglion Cells - pathology Retrospective Studies Time Factors Tomography, Optical Coherence - methods Visual Acuity
Title	Retinal and Optic Nerve Degeneration in Patients with Multiple Sclerosis Followed up for 5 Years
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