Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

Neuritic plaques, a pathological hallmark in Alzheimer's disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating neurites that accumulate autolysosomes. We found that, in the brains of patients with AD and in AD mouse models, Aβ plaque-associated Oli...

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Veröffentlicht in:	Nature neuroscience Jg. 22; H. 5; S. 719 - 728
Hauptverfasser:	Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, Ioannis, Gottimukkala, Kamalvishnu, Cutler, Roy G, Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A, Misra Sen, Jyoti, Gorospe, Myriam, Mattson, Mark P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Nature Publishing Group 01.05.2019
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - psychology Alzheimer's disease Amyloid beta-Peptides - administration & dosage Amyloid beta-Peptides - metabolism Animal models Animals Astrocytes Axons Cells (biology) Cellular Senescence - drug effects Cognitive ability Cyclin-dependent kinase inhibitors Dasatinib - administration & dosage Disease Models, Animal Female Galactosidase Glial stem cells Inflammation INK4 protein Interrogation Male Maze Learning - drug effects Mice, Transgenic Microglia Olig2 protein Oligodendrocyte Precursor Cells - metabolism Oligodendrocytes Phenotypes Plaque, Amyloid - ultrastructure Progenitor cells Prosencephalon - metabolism Prosencephalon - ultrastructure Proteins Quercetin - administration & dosage Senescence Senile plaques β-Amyloid β-Galactosidase
ISSN:	1097-6256, 1546-1726, 1546-1726
Online-Zugang:	Volltext
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