A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer

Purpose This study was conducted to investigate the safety and tolerability of increasing doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor activity and of the pharmacokinetics of curcumin were secondary objectives. Methods In this phase I, single-center, o...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 82; no. 4; pp. 695 - 706
Main Authors:	Greil, Richard, Greil-Ressler, Sigrun, Weiss, Lukas, Schönlieb, Charlotte, Magnes, Teresa, Radl, Bianca, Bolger, Gordon T., Vcelar, Brigitta, Sordillo, Peter P.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2018 Springer Nature B.V
Subjects:	Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Antitumor agents Cancer Cancer Research Clinical trials Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal cancer Curcumin Curcumin - administration & dosage Curcumin - adverse effects Curcumin - pharmacokinetics Dose-Response Relationship, Drug Drug Monitoring - methods Drug Tolerance Drug-Related Side Effects and Adverse Reactions - blood Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - etiology Female Hemoglobin Hemoglobins - analysis Hemolysis Hemolysis - drug effects Humans Intravenous administration Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Invasiveness Neoplasm Metastasis - drug therapy Neoplasm Metastasis - pathology Neoplasm Staging Oncology Original Original Article Pharmacokinetics Pharmacology/Toxicology Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Toxicity Treatment Outcome Tumor markers Tumors Hemolysis Prostate carcinoma Curcumin Phase I cancer trials Colon carcinoma Lipocurc
ISSN:	0344-5704, 1432-0843, 1432-0843
Online Access:	Get full text
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