Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

Alpha-Synuclein (α-Syn) is a central protein in the pathogenesis of synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease (PD). Although its role in neurotransmission is well established, the precise role of this protein in disease pathogenesis is still not fully un...

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Veröffentlicht in:	Frontiers in neuroscience Jg. 14; S. 578993
Hauptverfasser:	Gilmozzi, Valentina, Gentile, Giovanna, Castelo Rueda, Maria Paulina, Hicks, Andrew A., Pramstaller, Peter P., Zanon, Alessandra, Lévesque, Martin, Pichler, Irene
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Lausanne Frontiers Research Foundation 06.10.2020 Frontiers Media S.A
Schlagworte:	aggregation alpha-synuclein Amino acids Axons Cardiolipin Cell membranes Disease Fatty acids Lewy bodies Lipids Membranes Mitochondria Movement disorders Mutation Neurodegeneration Neurodegenerative diseases Neurons Neuroscience Neurotransmission Oligomerization Parkinson's disease Pathogenesis Phospholipids Physiology Proteins Synuclein
ISSN:	1662-453X, 1662-4548, 1662-453X
Online-Zugang:	Volltext
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