Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice

Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects; however, its mechanisms of action remain unclear due to its low bioavailability. Microbial functions in the physiology result from the microbiota-host coevolution has profoundly affected host metabolism. Here, we sought to...

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Vydané v:International Journal of Obesity Ročník 44; číslo 1; s. 213 - 225
Hlavní autori: Wang, Pan, Li, Daotong, Ke, Weixin, Liang, Dong, Hu, Xiaosong, Chen, Fang
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Nature Publishing Group 01.01.2020
Predmet:
Adipocytes
Animals
Bioavailability
Body weight
Body weight gain
Coevolution
Composition
Diet
Diet, High-Fat
Digestive system
Food intake
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - genetics
Gastrointestinal tract
Gene sequencing
Gut microbiota
High fat diet
Insulin
Intestinal microflora
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestine
Lipid metabolism
Lipid Metabolism - drug effects
Lipids
Male
Metabolism
Mice
Mice, Inbred C57BL
Microbiomes
Microbiota
Microorganisms
Obesity
Obesity - metabolism
Oxidative Stress - drug effects
Resveratrol
Resveratrol - pharmacology
rRNA 16S
Transplantation
Transplants & implants
ISSN:0307-0565, 1476-5497, 1476-5497
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Shrnutí:Resveratrol (RSV) is a natural polyphenol with putative anti-obesity effects; however, its mechanisms of action remain unclear due to its low bioavailability. Microbial functions in the physiology result from the microbiota-host coevolution has profoundly affected host metabolism. Here, we sought to determine how beneficial microbiome caused by RSV interventions affects antiobesity. C57BL/6J mice were fed either standard diet (SD) or RSV (300 mg/kg/day) diet for 16 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Then, transplant the RSV-microbiota to high-fat diet (HFD)-fed mice (HFD-RSVT) to explore the function of microbiota. Body weight and food intake were monitored. Markers of lipid metabolism, inflammation, gut microbiota compostion, and intestinal barrier were determined. Mice treated with RSV shows a remarkable alteration in microbiota composition compared with that of SD-fed mice and is characterized by an enrichment of Bacteroides, Lachnospiraceae_NK4A136_group, Blautia, Lachnoclostridium, Parabacteroides, and Ruminiclostridium_9, collectively referred to as RSV-microbiota. We further explored whether RSV-microbiota has anti-obesity functions. Transplantation of the RSV-microbiota to high-fat diet (HFD)-fed mice (HFD-RSVT) was sufficient to decrease their weight gain and increase their insulin sensitivity. Moreover, RSV-microbiota was able to modulate lipid metabolism, stimulate the development of beige adipocytes in WAT, reduce inflammation and improve intestinal barrier function. Our study demonstrates that RSV-induced microbiota plays a key role in controlling obesity development and brings new insights to a potential therapy based on host-microbe interactions.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0307-0565
1476-5497
1476-5497
DOI:10.1038/s41366-019-0332-1