Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

High-grade glioma (HGG) is highly resistant to therapy, prompting us to investigate the contribution of insulin-like growth factor receptor (IGF-1R), linked with radioresistance in other cancers. IGF-1R immunohistochemistry in 305 adult HGG (aHGG) and 103 paediatric/young adult HGG (pHGG) cases reve...

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Veröffentlicht in:	British journal of cancer Jg. 122; H. 5; S. 624 - 629
Hauptverfasser:	Simpson, Aaron D., Soo, Ying Wei Jenetta, Rieunier, Guillaume, Aleksic, Tamara, Ansorge, Olaf, Jones, Chris, Macaulay, Valentine M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.03.2020 Nature Publishing Group
Schlagworte:	631/67/1922 692/4028/67/1922 Apoptosis Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brief Communication Cancer Research Cell Line, Tumor Cell lines DNA Damage Drug Resistance Epidemiology Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma - radiotherapy Humans Immunohistochemistry Insulin Insulin-like growth factors Molecular Medicine Neoplasm Grading Oncology Pediatrics Pyrazoles - pharmacology Radiation Tolerance - drug effects Radioresistance Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Signal Transduction - drug effects Tissue Array Analysis Triazines - pharmacology
ISSN:	0007-0920, 1532-1827, 1532-1827
Online-Zugang:	Volltext
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