Human T cell immunosenescence and inflammation in aging

Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The aging process is driven by a finite number of inter‐related mechanisms that ultimately lead to the emergence of characteristic phenotypes, inclu...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 102; no. 4; pp. 977 - 988
Main Authors:	Bektas, Arsun, Schurman, Shepherd H., Sen, Ranjan, Ferrucci, Luigi
Format:	Journal Article
Language:	English
Published:	Bethesda, MD, USA Society for Leukocyte Biology 01.10.2017 Oxford University Press
Subjects:	Aging Aging - immunology Animals Cell activation Cellular Senescence - immunology Chronic illnesses Damage accumulation Health risks Humans immune dysregulation Immune system Immunoregulation Immunosenescence Inflammation inflamm‐aging Lymphocytes Lymphocytes T NF-kappa B - immunology NF-κB protein NF‐κB Older people Reviews Risk analysis Risk factors Subgroups T-Lymphocytes, Regulatory - immunology NF-κB inflamm-aging immune dysregulation
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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