Human T cell immunosenescence and inflammation in aging

Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The aging process is driven by a finite number of inter‐related mechanisms that ultimately lead to the emergence of characteristic phenotypes, inclu...

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Vydané v:	Journal of leukocyte biology Ročník 102; číslo 4; s. 977 - 988
Hlavní autori:	Bektas, Arsun, Schurman, Shepherd H., Sen, Ranjan, Ferrucci, Luigi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Bethesda, MD, USA Society for Leukocyte Biology 01.10.2017 Oxford University Press
Predmet:	Aging Aging - immunology Animals Cell activation Cellular Senescence - immunology Chronic illnesses Damage accumulation Health risks Humans immune dysregulation Immune system Immunoregulation Immunosenescence Inflammation inflamm‐aging Lymphocytes Lymphocytes T NF-kappa B - immunology NF-κB protein NF‐κB Older people Reviews Risk analysis Risk factors Subgroups T-Lymphocytes, Regulatory - immunology NF-κB inflamm-aging immune dysregulation
ISSN:	0741-5400, 1938-3673, 1938-3673
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Abstract	Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The aging process is driven by a finite number of inter‐related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress‐buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low‐grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF‐κB activation and its dysregulation and how NF‐κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (Tregs). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging.
AbstractList	The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low-grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF-κB activation and its dysregulation and how NF-κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (Tregs). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging.The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low-grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF-κB activation and its dysregulation and how NF-κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (Tregs). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging. Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time.The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low-grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF-κB activation and its dysregulation and how NF-κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (Tregs). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging. Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The aging process is driven by a finite number of inter‐related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress‐buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low‐grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF‐κB activation and its dysregulation and how NF‐κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (Tregs). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging. The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage. Central to this paradigm are changes in the immune system and the chronic low-grade proinflammatory state that affect many older individuals, even when they are apparently healthy and free of risk factors. Independent of chronological age, high circulating levels of proinflammatory markers are associated with a high risk of multiple adverse health outcomes in older persons. In this review, we discuss current theories about causes and consequences of the proinflammatory state of aging, with a focus on changes in T cell function. We examine the role of NF-κB activation and its dysregulation and how NF-κB activity differs among subgroups of T cells. We explore emerging hypotheses about immunosenescence and changes in T cell behavior with age, including consideration of the T cell antigen receptor and regulatory T cells (T ). We conclude by illustrating how research using advanced technology is uncovering clues at the core of inflammation and aging. Some of the preliminary work in this field is already improving our understanding of the complex mechanisms by which immunosenescence of T cells is intertwined during human aging.
Author	Sen, Ranjan Bektas, Arsun Schurman, Shepherd H. Ferrucci, Luigi
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References	2014; 139 2013; 4 2005; 174 2015; 70 2010; 18 2015; 144 1997; 277 2017; 89 2008; 37 2012; 18 2005; 60 2012; 14 2013; 8 2013; 5 2012; 11 2016; 36 2015; 372 2009; 11 2009; 10 2015; 82 2005; 105 2002; 420 2006; 26 2008; 22 2000; 121 2013; 110 2012; 26 2016; 158 2012; 24 2010; 6 2010; 9 2009; 17 2017; 61 2010; 32 2011; 2 2015; 528 2003; 38 2001; 22 2012; 36 2014; 41 2016; 16 2007; 13 2014; 44 2001; 21 2015; 195 2004; 52 2016; 7 2015; 194 2003; 108 2000; 908 2006; 43 2006; 49 2015; 112 2011; 1813 2008; 43 2016; 214 2016; 29 2005; 12 2016; 23 2009; 106 1996; 88 2015; 36 2000; 6 2011; 10 2011; 12 2011; 14 2003; 114 2014; 174 2014; 60 2005; 22 2012; 209 2013; 19 2015; 45 2013; 18 2014; 5 2013; 14 2013; 10 2013; 153 2012; 69 2006; 127 2014; 9 2007; 21 2014; 6 2015; 14 2015; 6 2015; 17 2014; 92 2013; 48 2015; 16 2006; 12 2000; 21 2015; 10 2011; 30 2009; 130 2016; 55 2009; 30 2012; 3 2012; 1 2013; 35 2017; 13 1995; 108 2005; 205 2016; 64 2016; 375 2017 2015 2017; 187 2007; 42 2008; 84 2012; 4 1998; 102 2016; 68 2012; 9 23598398 - Nat Immunol. 2013 May;14(5):428-36 25981968 - Trends Immunol. 2015 Jun;36(6):344-53 22936935 - Front Immunol. 2012 Aug 22;3:271 25792098 - Lancet Neurol. 2015 Apr;14(4):388-405 14962155 - J Am Geriatr Soc. 2004 Mar;52(3):399-404 23730304 - Front Immunol. 2013 May 20;4:121 26658771 - Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26 28392564 - Nat Rev Nephrol. 2017 Jun;13(6):368-380 22870907 - Antioxid Redox Signal. 2013 Jul 20;19(3):321-9 11164473 - Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201 25614163 - Eur Respir J. 2015 Mar;45(3):790-806 25011077 - Mech Ageing Dev. 2014 Jul;139:49-57 22372596 - Aging Cell. 2012 Jun;11(3):509-19 16783459 - J Clin Immunol. 2006 May;26(3):193-203 18780874 - J Leukoc Biol. 2008 Dec;84(6):1454-61 23938363 - Nat Rev Genet. 2013 Sep;14(9):601-7 15972602 - J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65 17115046 - Nat Med. 2006 Dec;12(12):1365-71 22560294 - Curr Opin Immunol. 2012 Aug;24(4):482-7 24296590 - Gerontology. 2014;60(2):130-7 19494434 - J Alzheimers Dis. 2009;17(1):91-103 27625432 - J Infect Dis. 2016 Oct 1;214 Suppl 2:S58-66 23056007 - Front Genet. 2012 Sep 25;3:189 21668623 - Aging Cell. 2011 Oct;10(5):868-78 12954485 - Exp Gerontol. 2003 Sep;38(9):981-7 21296109 - Biochim Biophys Acta. 2011 May;1813(5):878-88 16496121 - Diabetologia. 2006 Apr;49(4):744-7 25540326 - Sci Transl Med. 2014 Dec 24;6(268):268ra179 27521521 - Semin Cell Dev Biol. 2017 Jan;61:3-11 22830639 - Immun Ageing. 2012 Jul 25;9(1):15 26941738 - Front Immunol. 2016 Feb 25;7:41 23023500 - Nat Med. 2012 Oct;18(10):1518-24 23812748 - Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11934-9 19540259 - Mech Ageing Dev. 2009 Aug;130(8):509-17 19878143 - Aging Cell. 2010 Feb;9(1):19-31 11521070 - J Endotoxin Res. 2000;6(6):453-7 20933612 - Ageing Res Rev. 2011 Jul;10(3):370-8 11154260 - Mol Cell Biol. 2001 Feb;21(3):721-30 23474627 - Aging (Albany NY). 2013 Jan;5(1):84-93 20686723 - Mol Biosyst. 2010 Oct;6(10):1983-92 18775362 - Endocrinol Metab Clin North Am. 2008 Sep;37(3):753-68, x-xi 9042845 - JAMA. 1997 Mar 5;277(9):728-34 20812785 - Antioxid Redox Signal. 2011 Apr 15;14(8):1551-85 8881749 - Immunology. 1996 Aug;88(4):501-7 27304509 - Cell Metab. 2016 Jun 14;23 (6):1093-1112 22395709 - Nat Med. 2012 Mar 06;18(3):363-74 21399611 - EMBO J. 2011 Apr 20;30(8):1536-48 20701600 - Aging Cell. 2010 Oct;9(5):667-84 15905594 - J Immunol. 2005 Jun 1;174(11):7446-52 10858586 - Neurobiol Aging. 2000 May-Jun;21(3):383-421 26583116 - Biomed Res Int. 2015;2015:521957 7580284 - Int Arch Allergy Immunol. 1995 Nov;108(3):205-10 14568895 - Circulation. 2003 Nov 11;108(19):2317-22 19805069 - Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17031-6 22365666 - Immunity. 2012 Feb 24;36(2):288-97 27353257 - Ageing Res Rev. 2016 Aug;29:90-112 10911963 - Ann N Y Acad Sci. 2000 Jun;908:244-54 27198731 - Clin Exp Immunol. 2017 Jan;187(1):44-52 20395951 - Obesity (Silver Spring). 2010 Dec;18(12):2354-61 15572589 - Blood. 2005 Mar 15;105(6):2294-9 27108521 - Nat Rev Immunol. 2016 Jun;16(6):367-77 19203223 - Antioxid Redox Signal. 2009 Sep;11(9):2209-22 17267287 - Trends Mol Med. 2007 Mar;13(3):94-102 26044074 - Maturitas. 2015 Sep;82(1):50-5 26188489 - Clin Exp Med. 2016 Aug;16(3):257-63 26773975 - Mech Ageing Dev. 2016 Sep;158:27-37 25404168 - Nat Commun. 2014 Nov 18;5:5366 22891274 - J Exp Med. 2012 Aug 27;209(9):1655-70 19540809 - Trends Immunol. 2009 Jul;30(7):306-12 26087330 - Exp Gerontol. 2015 Oct;70:37-45 25553802 - Aging (Albany NY). 2014 Nov;6(11):957-74 18055696 - Genes Dev. 2007 Dec 15;21(24):3244-57 15647756 - Cell Death Differ. 2005 Feb;12 (2):177-83 25888703 - J Immunol. 2015 May 1;194(9):4073-80 26109645 - J Immunol. 2015 Aug 1;195(3):944-52 9720652 - Mech Ageing Dev. 1998 May 15;102(2-3):199-209 12490960 - Nature. 2002 Dec 19-26;420(6917):868-74 15974640 - Drugs Aging. 2005;22(6):495-515 25266669 - Eur J Immunol. 2014 Dec;44(12):3475-83 22466672 - Cell Mol Life Sci. 2012 May;69(10):1615-23 22302935 - Genes Dev. 2012 Feb 1;26(3):203-34 23805138 - Front Immunol. 2013 Jun 24;4:161 23506673 - Immun Ageing. 2013 Mar 19;10(1):11 23746838 - Cell. 2013 Jun 6;153(6):1194-217 18267981 - FASEB J. 2008 Jul;22(7):2142-50 17029132 - Clin Infect Dis. 2006 Nov 1;43(9):1143-51 23197761 - Stem Cells Transl Med. 2012 Feb;1(2):142-9 22396894 - Aging Dis. 2011 Dec;2(6):449-65 25761112 - PLoS One. 2015 Mar 11;10(3):e0116489 24819230 - PLoS One. 2014 May 12;9(5):e97171 27983788 - Anal Chem. 2017 Jan 17;89(2):1254-1259 26459351 - J Immunol. 2015 Nov 15;195(10):4699-711 17606347 - Exp Gerontol. 2007 Aug;42(8):753-61 26580010 - Nature. 2015 Dec 3;528(7580):44-6 23385138 - Aging (Albany NY). 2013 Jan;5(1):18-36 23717651 - PLoS One. 2013 May 22;8(5):e64702 17870272 - Exp Gerontol. 2008 Feb;43(2):61-5 24801091 - Int J Cardiol. 2014 Jul 1;174(3):590-9 26580014 - Nature. 2015 Dec 3;528(7580):137-41 27103044 - Rev Invest Clin. 2016 Mar-Apr;68(2):84-91 22833059 - AIDS Rev. 2012 Jul-Sep;14(3):159-67 28017881 - Ageing Res Rev. 2017 Jul;36:117-124 12887920 - Cell. 2003 Jul 25;114(2):181-90 20179931 - Semin Immunopathol. 2010 Jun;32(2):95-106 25367565 - Immunity. 2014 Oct 16;41(4):509-11 19198593 - Nat Immunol. 2009 Mar;10(3):281-8 26254232 - Brain Behav Immun. 2016 Jul;55:138-150 11738996 - Trends Immunol. 2001 Dec;22(12):665-9 25093579 - Immunology. 2015 Jan;144(1):1-10 23425777 - Aging (Albany NY). 2012 Dec;4(12):861-77 22415616 - Age (Dordr). 2013 Jun;35(3):985-91 23589904 - Curr Pharm Des. 2013;19(9):1675-9 15882347 - Immunol Rev. 2005 Jun;205:94-103 26490707 - Nat Commun. 2015 Oct 22;6:8570 24217812 - Immunol Cell Biol. 2014 Jan;92(1):72-9 23964277 - Front Immunol. 2013 Aug 06;4:231 25898983 - BMC Genomics. 2015 Apr 22;16:333 25277040 - Neurobiol Aging. 2015 Jan;36(1):81-9 27626517 - N Engl J Med. 2016 Sep 15;375(11):1019-32 25916341 - N Engl J Med. 2015 May 28;372(22):2087-96 25367574 - Immunity. 2014 Oct 16;41(4):605-19 21772277 - Nat Immunol. 2011 Jul 19;12(8):689-94 16750842 - Mech Ageing Dev. 2006 Aug;127(8):695-704 26214134 - Nat Cell Biol. 2015 Aug;17(8):1004-13 26578790 - Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10 24579731 - Crit Rev Oncog. 2013;18(6):489-513 23019125 - Genes Dev. 2012 Oct 15;26(20):2311-24 24055797 - Exp Gerontol. 2013 Dec;48(12):1379-86
References_xml	– volume: 9 start-page: e97171 year: 2014 article-title: Contribution of intestinal barrier damage, microbial translocation and HIV‐1 infection status to an inflammaging signature publication-title: PLoS One – volume: 4 start-page: 121 year: 2013 article-title: T cell aging: a review of the transcriptional changes determined from genome‐wide analysis publication-title: Front. Immunol. – volume: 153 start-page: 1194 year: 2013 end-page: 1217 article-title: The hallmarks of aging publication-title: Cell – volume: 61 start-page: 3 year: 2017 end-page: 11 article-title: Tissue‐specific contribution of macrophages to wound healing publication-title: Semin. Cell Dev. Biol. – volume: 10 start-page: e0116489 year: 2015 article-title: Detection of a novel, integrative aging process suggests complex physiological integration publication-title: PLoS One – volume: 55 start-page: 138 year: 2016 end-page: 150 article-title: Microglia in Alzheimer's disease: a multifaceted relationship publication-title: Brain Behav. Immun. – volume: 30 start-page: 306 year: 2009 end-page: 312 article-title: CD28(–) T cells: their role in the age‐associated decline of immune function publication-title: Trends Immunol. – volume: 8 start-page: e64702 year: 2013 article-title: Accelerated aging in HIV/AIDS: novel biomarkers of senescent human CD8+ T cells publication-title: PLoS One – volume: 18 start-page: 489 year: 2013 end-page: 513 article-title: Immunosenescence and cancer publication-title: Crit. Rev. Oncog. – volume: 82 start-page: 50 year: 2015 end-page: 55 article-title: Immunosenescence: implications for response to infection and vaccination in older people publication-title: Maturitas – volume: 7 start-page: 41 year: 2016 article-title: T‐Cell immunity to influenza in older adults: a pathophysiological framework for development of more effective vaccines publication-title: Front. Immunol. – volume: 16 start-page: 367 year: 2016 end-page: 377 article-title: T cell responses to cytomegalovirus publication-title: Nat. Rev. Immunol. – volume: 17 start-page: 91 year: 2009 end-page: 103 article-title: Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease publication-title: J. Alzheimers Dis. – volume: 3 start-page: 271 year: 2012 article-title: Homeostasis of lymphocytes and monocytes in frequent blood donors publication-title: Front. Immunol. – volume: 13 start-page: 368 year: 2017 end-page: 380 article-title: The immunology of atherosclerosis publication-title: Nat. Rev. Nephrol. – volume: 30 start-page: 1536 year: 2011 end-page: 1548 article-title: p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype publication-title: EMBO J. – volume: 1813 start-page: 878 year: 2011 end-page: 888 article-title: The pro‐ and anti‐inflammatory properties of the cytokine interleukin‐6 publication-title: Biochim. Biophys. Acta – volume: 36 start-page: 81 year: 2015 end-page: 89 article-title: Clinical relevance of specific T‐cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease publication-title: Neurobiol. Aging – volume: 195 start-page: 4699 year: 2015 end-page: 4711 article-title: Low thymic activity and dendritic cell numbers are associated with the immune response to primary viral infection in elderly humans publication-title: J. Immunol. – volume: 32 start-page: 95 year: 2010 end-page: 106 article-title: Regulatory T cells: roles of T cell receptor for their development and function publication-title: Semin. Immunopathol. – volume: 174 start-page: 590 year: 2014 end-page: 599 article-title: Immunosenescence and inflammation characterize chronic heart failure patients with more advanced disease publication-title: Int. J. Cardiol. – volume: 18 start-page: 363 year: 2012 end-page: 374 article-title: The cellular and signaling networks linking the immune system and metabolism in disease publication-title: Nat. Med. – volume: 41 start-page: 605 year: 2014 end-page: 619 article-title: miR‐155 promotes T follicular helper cell accumulation during chronic, low‐grade inflammation publication-title: Immunity – volume: 16 start-page: 333 year: 2015 article-title: Transcriptomic profiles of aging in purified human immune cells publication-title: BMC Genomics – volume: 10 start-page: 281 year: 2009 end-page: 288 article-title: The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules publication-title: Nat. Immunol. – volume: 187 start-page: 44 year: 2017 end-page: 52 article-title: Ageing and inflammation in patients with HIV infection publication-title: Clin. Exp. Immunol. – volume: 24 start-page: 482 year: 2012 end-page: 487 article-title: Homeostasis and function of regulatory T cells in aging publication-title: Curr. Opin. Immunol. – volume: 21 start-page: 721 year: 2001 end-page: 730 article-title: The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA‐stabilizing factor HuR publication-title: Mol. Cell. Biol. – volume: 60 start-page: 556 year: 2005 end-page: 565 article-title: An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 29 start-page: 90 year: 2016 end-page: 112 article-title: A synopsis on aging‐theories, mechanisms and future prospects publication-title: Ageing Res. Rev. – volume: 43 start-page: 61 year: 2008 end-page: 65 article-title: The immune system in extreme longevity publication-title: Exp. Gerontol. – volume: 48 start-page: 1379 year: 2013 end-page: 1386 article-title: The Th17/Treg balance is disturbed during aging publication-title: Exp. Gerontol. – volume: 45 start-page: 790 year: 2015 end-page: 806 article-title: Mechanisms of development of multimorbidity in the elderly publication-title: Eur. Respir. J. – volume: 908 start-page: 244 year: 2000 end-page: 254 article-title: Inflamm‐aging. An evolutionary perspective on immunosenescence publication-title: Ann. N. Y. Acad. Sci. – volume: 18 start-page: 2354 year: 2010 end-page: 2361 article-title: Body fat distribution and inflammation among obese older adults with and without metabolic syndrome publication-title: Obesity (Silver Spring) – volume: 130 start-page: 509 year: 2009 end-page: 517 article-title: Aging and human CD4(+) regulatory T cells publication-title: Mech. Ageing Dev. – volume: 17 start-page: 1004 year: 2015 end-page: 1013 article-title: NF‐κB activation impairs somatic cell reprogramming in ageing publication-title: Nat. Cell Biol. – volume: 12 start-page: 177 year: 2005 end-page: 183 article-title: Role of NF‐kappaB signaling pathway in increased tumor necrosis factor‐alpha‐induced apoptosis of lymphocytes in aged humans publication-title: Cell Death Differ. – volume: 44 start-page: 3475 year: 2014 end-page: 3483 article-title: Defining Th‐cell subsets in a classical and tissue‐specific manner: examples from the skin publication-title: Eur. J. Immunol. – volume: 102 start-page: 199 year: 1998 end-page: 209 article-title: Altered cytokine production in the elderly publication-title: Mech. Ageing Dev. – volume: 26 start-page: 193 year: 2006 end-page: 203 article-title: Differential sensitivity of naive and memory subsets of human CD8+ T cells to TNF‐alpha‐induced apoptosis publication-title: J. Clin. Immunol. – volume: 372 start-page: 2087 year: 2015 end-page: 2096 article-title: Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults publication-title: N. Engl. J. Med. – volume: 420 start-page: 868 year: 2002 end-page: 874 article-title: Inflammation in atherosclerosis publication-title: Nature – volume: 84 start-page: 1454 year: 2008 end-page: 1461 article-title: The frequency of regulatory CD3+CD8+CD28– CD25+ T lymphocytes in human peripheral blood increases with age publication-title: J. Leukoc. Biol. – volume: 9 start-page: 667 year: 2010 end-page: 684 article-title: Fat tissue, aging, and cellular senescence publication-title: Aging Cell – volume: 106 start-page: 17031 year: 2009 end-page: 17036 article-title: Cell surface‐bound IL‐1alpha is an upstream regulator of the senescence‐associated IL‐6/IL‐8 cytokine network publication-title: Proc. Natl. Acad. Sci. USA – volume: 5 start-page: 84 year: 2013 end-page: 93 article-title: The role of inflammation in age‐related disease publication-title: Aging (Albany NY) – start-page: 521957 year: 2015 article-title: Functional and phenotypic plasticity of CD4(+) T cell subsets publication-title: BioMed Res. Int. – volume: 70 start-page: 37 year: 2015 end-page: 45 article-title: Gene expression markers of age‐related inflammation in two human cohorts publication-title: Exp. Gerontol. – volume: 60 start-page: 130 year: 2014 end-page: 137 article-title: Regulatory T cells and the immune aging process: a mini‐review publication-title: Gerontology – volume: 528 start-page: 44 year: 2015 end-page: 46 article-title: Metabolism: inflammation keeps old mice healthy publication-title: Nature – volume: 105 start-page: 2294 year: 2005 end-page: 2299 article-title: The origins of age‐related proinflammatory state publication-title: Blood – volume: 195 start-page: 944 year: 2015 end-page: 952 article-title: IL‐6 and ICOS antagonize bim and promote regulatory T cell accrual with age publication-title: J. Immunol. – volume: 6 start-page: 1983 year: 2010 end-page: 1992 article-title: Complex patterns of gene expression in human T cells during in vivo aging publication-title: Mol. Biosyst. – volume: 4 start-page: 861 year: 2012 end-page: 877 article-title: Answering the ultimate question “what is the proximal cause of aging?” publication-title: Aging (Albany NY) – volume: 49 start-page: 744 year: 2006 end-page: 747 article-title: Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin publication-title: Diabetologia – volume: 68 start-page: 84 year: 2016 end-page: 91 article-title: The role of immunosenescence in the development of age‐related diseases publication-title: Rev. Invest. Clin. – volume: 14 start-page: 1551 year: 2011 end-page: 1585 article-title: Aging and immune function: molecular mechanisms to interventions publication-title: Antioxid. Redox Signal. – volume: 22 start-page: 2142 year: 2008 end-page: 2150 article-title: Nuclear factor‐kappaB‐dependent reversal of aging‐induced alterations in T cell cytokines publication-title: FASEB J. – volume: 108 start-page: 205 year: 1995 end-page: 210 article-title: Reference intervals for human peripheral blood lymphocyte subpopulations from ‘healthy’ young and aged subjects publication-title: Int. Arch. Allergy Immunol. – volume: 9 start-page: 15 year: 2012 article-title: Hallmarks of human “immunosenescence”: adaptation or dysregulation? publication-title: Immun. Ageing – volume: 4 start-page: 231 year: 2013 article-title: The impact of aging on regulatory T‐cells publication-title: Front. Immunol. – volume: 11 start-page: 2209 year: 2009 end-page: 2222 article-title: Redox regulation of nuclear post‐translational modifications during NF‐kappaB activation publication-title: Antioxid. Redox Signal. – volume: 22 start-page: 665 year: 2001 end-page: 669 article-title: Atherosclerosis as an autoimmune disease: an update publication-title: Trends Immunol. – volume: 114 start-page: 181 year: 2003 end-page: 190 article-title: Induction of TNF receptor I‐mediated apoptosis via two sequential signaling complexes publication-title: Cell – volume: 6 start-page: 453 year: 2000 end-page: 457 article-title: Molecular mechanisms of NF‐kappaB activation induced by bacterial lipopolysaccharide through Toll‐like receptors publication-title: J. Endotoxin Res. – volume: 19 start-page: 321 year: 2013 end-page: 329 article-title: Alternative perspectives on aging in : reactive oxygen species or hyperfunction? publication-title: Antioxid. Redox Signal. – volume: 36 start-page: 344 year: 2015 end-page: 353 article-title: Regulatory T cell identity: formation and maintenance publication-title: Trends Immunol. – volume: 43 start-page: 1143 year: 2006 end-page: 1151 article-title: Seroprevalence of cytomegalovirus infection in the United States, 1988–1994 publication-title: Clin. Infect. Dis. – volume: 110 start-page: 11934 year: 2013 end-page: 11939 article-title: RNA splicing regulates the temporal order of TNF‐induced gene expression publication-title: Proc. Natl. Acad. Sci. USA – volume: 11 start-page: 509 year: 2012 end-page: 519 article-title: Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells publication-title: Aging Cell – volume: 37 start-page: 753 year: 2008 end-page: 768 article-title: The adipocyte as an endocrine cell publication-title: Endocrinol. Metab. Clin. North Am. – volume: 121 start-page: 187 year: 2000 end-page: 201 article-title: Age‐related change in peripheral blood T‐lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study publication-title: Mech. Ageing Dev. – volume: 2 start-page: 449 year: 2011 end-page: 465 article-title: NF‐κB in aging and disease publication-title: Aging Dis. – volume: 18 start-page: 1518 year: 2012 end-page: 1524 article-title: Decline in miR‐181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity publication-title: Nat. Med. – volume: 26 start-page: 2311 year: 2012 end-page: 2324 article-title: Nuclear lamina defects cause ATM‐dependent NF‐κB activation and link accelerated aging to a systemic inflammatory response publication-title: Genes Dev. – volume: 127 start-page: 695 year: 2006 end-page: 704 article-title: The immune risk phenotype is associated with IL‐6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning publication-title: Mech. Ageing Dev. – volume: 21 start-page: 3244 year: 2007 end-page: 3257 article-title: Motif module map reveals enforcement of aging by continual NF‐kappaB activity publication-title: Genes Dev. – volume: 92 start-page: 72 year: 2014 end-page: 79 article-title: How T follicular helper cells and the germinal centre response change with age publication-title: Immunol. Cell Biol. – volume: 112 start-page: E6301 year: 2015 end-page: E6310 article-title: JAK inhibition alleviates the cellular senescence‐associated secretory phenotype and frailty in old age publication-title: Proc. Natl. Acad. Sci. USA – volume: 52 start-page: 399 year: 2004 end-page: 404 article-title: Diverse effect of inflammatory markers on insulin resistance and insulin‐resistance syndrome in the elderly publication-title: J. Am. Geriatr. Soc. – volume: 23 start-page: 1093 year: 2016 end-page: 1112 article-title: Effects of sex, strain, and energy intake on hallmarks of aging in mice publication-title: Cell Metab. – volume: 375 start-page: 1019 year: 2016 end-page: 1032 article-title: Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older publication-title: N. Engl. J. Med. – volume: 144 start-page: 1 year: 2015 end-page: 10 article-title: Immuno‐miRs: critical regulators of T‐cell development, function and ageing publication-title: Immunology – volume: 6 start-page: 268ra179 year: 2014 article-title: mTOR inhibition improves immune function in the elderly publication-title: Sci. Transl. Med. – volume: 158 start-page: 27 year: 2016 end-page: 37 article-title: The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence publication-title: Mech. Ageing Dev. – volume: 4 start-page: 161 year: 2013 article-title: IL‐15 fosters age‐driven regulatory T cell accrual in the face of declining IL‐2 levels publication-title: Front. Immunol. – volume: 6 start-page: 957 year: 2014 end-page: 969 article-title: Age‐associated changes in basal NF‐κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase publication-title: Aging (Albany NY) – volume: 19 start-page: 1675 year: 2013 end-page: 1679 article-title: Immune system, cell senescence, aging and longevity—inflamm‐aging reappraised publication-title: Curr. Pharm. Des. – volume: 9 start-page: 19 year: 2010 end-page: 31 article-title: Age‐related alterations of gene expression patterns in human CD8+ T cells publication-title: Aging Cell – volume: 14 start-page: 159 year: 2012 end-page: 167 article-title: Cytomegalovirus, aging, and HIV: a perfect storm publication-title: AIDS Rev. – volume: 26 start-page: 203 year: 2012 end-page: 234 article-title: NF‐kB, the first quarter‐century: remarkable progress and outstanding questions publication-title: Genes Dev. – volume: 10 start-page: 370 year: 2011 end-page: 378 article-title: Impact of age on T cell signaling: a general defect or specific alterations? publication-title: Ageing Res. Rev. – volume: 12 start-page: 689 year: 2011 end-page: 694 article-title: Hierarchies of NF‐κB target‐gene regulation publication-title: Nat. Immunol. – volume: 5 start-page: 5366 year: 2014 article-title: Age‐related variations in the methylome associated with gene expression in human monocytes and T cells publication-title: Nat. Commun. – volume: 14 start-page: 388 year: 2015 end-page: 405 article-title: Neuroinflammation in Alzheimer's disease publication-title: Lancet Neurol. – volume: 64 start-page: 111 year: 2016 end-page: 126 article-title: Inflammaging and anti‐inflammaging: the role of cytokines in extreme longevity publication-title: Arch. Immunol. Ther. Exp. (Warsz.) – volume: 89 start-page: 1254 year: 2017 end-page: 1259 article-title: Data streaming for metabolomics: accelerating data processing and analysis from days to minutes publication-title: Anal. Chem. – volume: 528 start-page: 137 year: 2015 end-page: 141 article-title: Depletion of fat‐resident Treg cells prevents age‐associated insulin resistance publication-title: Nature – volume: 139 start-page: 49 year: 2014 end-page: 57 article-title: Inflamm‐aging does not simply reflect increases in pro‐inflammatory markers publication-title: Mech. Ageing Dev. – volume: 14 start-page: 601 year: 2013 end-page: 607 article-title: Omics technologies and the study of human ageing publication-title: Nat. Rev. Genet. – volume: 108 start-page: 2317 year: 2003 end-page: 2322 article-title: Inflammatory markers and onset of cardiovascular events: results from the Health ABC study publication-title: Circulation – volume: 10 start-page: 11 year: 2013 article-title: Toll like receptor signaling in “inflammaging”: microRNA as new players publication-title: Immun. Ageing – volume: 13 start-page: 94 year: 2007 end-page: 102 article-title: Immune remodeling: lessons from repertoire alterations during chronological aging and in immune‐mediated disease publication-title: Trends Mol. Med. – volume: 42 start-page: 753 year: 2007 end-page: 761 article-title: No immune risk profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study publication-title: Exp. Gerontol. – volume: 5 start-page: 18 year: 2013 end-page: 36 article-title: Age‐associated alterations in inducible gene transcription in human CD4+ T lymphocytes publication-title: Aging (Albany NY) – volume: 214 start-page: S58 issue: Suppl 2 year: 2016 end-page: S66 article-title: Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV‐1 disease progression publication-title: J. Infect. Dis. – volume: 41 start-page: 509 year: 2014 end-page: 511 article-title: MicroRNAs in Tfh cells: micromanaging inflammaging publication-title: Immunity – volume: 3 start-page: 189 year: 2012 article-title: What is the proximal cause of aging? publication-title: Front. Genet. – volume: 88 start-page: 501 year: 1996 end-page: 507 article-title: Expansion of cytotoxic CD8+ CD28‐ T cells in healthy ageing people, including centenarians publication-title: Immunology – volume: 10 start-page: 868 year: 2011 end-page: 878 article-title: Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing publication-title: Aging Cell – volume: 277 start-page: 728 year: 1997 end-page: 734 article-title: Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled publication-title: JAMA – volume: 16 start-page: 257 year: 2016 end-page: 263 article-title: T cell senescence and cardiovascular diseases publication-title: Clin. Exp. Med. – volume: 36 start-page: 117 year: 2016 end-page: 124 article-title: HIV‐associated cellular senescence: a contributor to accelerated aging publication-title: Ageing Res. Rev. – volume: 205 start-page: 94 year: 2005 end-page: 103 article-title: T cells in aging mice: genetic, developmental, and biochemical analyses publication-title: Immunol. Rev. – volume: 22 start-page: 495 year: 2005 end-page: 515 article-title: Influenza vaccination in the elderly: impact on hospitalisation and mortality publication-title: Drugs Aging – volume: 12 start-page: 1365 year: 2006 end-page: 1371 article-title: Microbial translocation is a cause of systemic immune activation in chronic HIV infection publication-title: Nat. Med. – volume: 21 start-page: 383 year: 2000 end-page: 421 article-title: Inflammation and Alzheimer's disease publication-title: Neurobiol. Aging – volume: 69 start-page: 1615 year: 2012 end-page: 1623 article-title: Immune aging and autoimmunity publication-title: Cell. Mol. Life Sci. – volume: 194 start-page: 4073 year: 2015 end-page: 4080 article-title: Naive T cell maintenance and function in human aging publication-title: J. Immunol. – volume: 1 start-page: 142 year: 2012 end-page: 149 article-title: Concise review: role of mesenchymal stem cells in wound repair publication-title: Stem Cells Transl. Med. – volume: 14 start-page: 428 year: 2013 end-page: 436 article-title: Understanding immunosenescence to improve responses to vaccines publication-title: Nat. Immunol. – volume: 36 start-page: 288 year: 2012 end-page: 297 article-title: Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans publication-title: Immunity – year: 2017 – volume: 6 start-page: 8570 year: 2015 article-title: The transcriptional landscape of age in human peripheral blood publication-title: Nat. Commun. – volume: 209 start-page: 1655 year: 2012 end-page: 1670 article-title: miR‐146a controls the resolution of T cell responses in mice publication-title: J. Exp. Med. – volume: 38 start-page: 981 year: 2003 end-page: 987 article-title: Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence publication-title: Exp. Gerontol. – volume: 174 start-page: 7446 year: 2005 end-page: 7452 article-title: The influence of age on T cell generation and TCR diversity publication-title: J. Immunol. – volume: 35 start-page: 985 year: 2013 end-page: 991 article-title: The inverted CD4/CD8 ratio and associated parameters in 66‐year‐old individuals: the Swedish HEXA immune study publication-title: Age (Dordr.) – reference: 21399611 - EMBO J. 2011 Apr 20;30(8):1536-48 – reference: 23746838 - Cell. 2013 Jun 6;153(6):1194-217 – reference: 23598398 - Nat Immunol. 2013 May;14(5):428-36 – reference: 20812785 - Antioxid Redox Signal. 2011 Apr 15;14(8):1551-85 – reference: 25540326 - Sci Transl Med. 2014 Dec 24;6(268):268ra179 – reference: 15882347 - Immunol Rev. 2005 Jun;205:94-103 – reference: 23197761 - Stem Cells Transl Med. 2012 Feb;1(2):142-9 – reference: 25553802 - Aging (Albany NY). 2014 Nov;6(11):957-74 – reference: 15972602 - J Gerontol A Biol Sci Med Sci. 2005 May;60(5):556-65 – reference: 12954485 - Exp Gerontol. 2003 Sep;38(9):981-7 – reference: 23019125 - Genes Dev. 2012 Oct 15;26(20):2311-24 – reference: 19203223 - Antioxid Redox Signal. 2009 Sep;11(9):2209-22 – reference: 17267287 - Trends Mol Med. 2007 Mar;13(3):94-102 – reference: 25011077 - Mech Ageing Dev. 2014 Jul;139:49-57 – reference: 9042845 - JAMA. 1997 Mar 5;277(9):728-34 – reference: 18267981 - FASEB J. 2008 Jul;22(7):2142-50 – reference: 12887920 - Cell. 2003 Jul 25;114(2):181-90 – reference: 22372596 - Aging Cell. 2012 Jun;11(3):509-19 – reference: 27198731 - Clin Exp Immunol. 2017 Jan;187(1):44-52 – reference: 25981968 - Trends Immunol. 2015 Jun;36(6):344-53 – reference: 22891274 - J Exp Med. 2012 Aug 27;209(9):1655-70 – reference: 25277040 - Neurobiol Aging. 2015 Jan;36(1):81-9 – reference: 15974640 - Drugs Aging. 2005;22(6):495-515 – reference: 25404168 - Nat Commun. 2014 Nov 18;5:5366 – reference: 11164473 - Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201 – reference: 11738996 - Trends Immunol. 2001 Dec;22(12):665-9 – reference: 24217812 - Immunol Cell Biol. 2014 Jan;92(1):72-9 – reference: 23474627 - Aging (Albany NY). 2013 Jan;5(1):84-93 – reference: 25888703 - J Immunol. 2015 May 1;194(9):4073-80 – reference: 11521070 - J Endotoxin Res. 2000;6(6):453-7 – reference: 20395951 - Obesity (Silver Spring). 2010 Dec;18(12):2354-61 – reference: 23805138 - Front Immunol. 2013 Jun 24;4:161 – reference: 26087330 - Exp Gerontol. 2015 Oct;70:37-45 – reference: 24296590 - Gerontology. 2014;60(2):130-7 – reference: 26214134 - Nat Cell Biol. 2015 Aug;17(8):1004-13 – reference: 25916341 - N Engl J Med. 2015 May 28;372(22):2087-96 – reference: 24801091 - Int J Cardiol. 2014 Jul 1;174(3):590-9 – reference: 15905594 - J Immunol. 2005 Jun 1;174(11):7446-52 – reference: 17029132 - Clin Infect Dis. 2006 Nov 1;43(9):1143-51 – reference: 27103044 - Rev Invest Clin. 2016 Mar-Apr;68(2):84-91 – reference: 26578790 - Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10 – reference: 26044074 - Maturitas. 2015 Sep;82(1):50-5 – reference: 22870907 - Antioxid Redox Signal. 2013 Jul 20;19(3):321-9 – reference: 27626517 - N Engl J Med. 2016 Sep 15;375(11):1019-32 – reference: 10911963 - Ann N Y Acad Sci. 2000 Jun;908:244-54 – reference: 26459351 - J Immunol. 2015 Nov 15;195(10):4699-711 – reference: 18775362 - Endocrinol Metab Clin North Am. 2008 Sep;37(3):753-68, x-xi – reference: 10858586 - Neurobiol Aging. 2000 May-Jun;21(3):383-421 – reference: 11154260 - Mol Cell Biol. 2001 Feb;21(3):721-30 – reference: 23589904 - Curr Pharm Des. 2013;19(9):1675-9 – reference: 22560294 - Curr Opin Immunol. 2012 Aug;24(4):482-7 – reference: 26941738 - Front Immunol. 2016 Feb 25;7:41 – reference: 19540809 - Trends Immunol. 2009 Jul;30(7):306-12 – reference: 24579731 - Crit Rev Oncog. 2013;18(6):489-513 – reference: 22833059 - AIDS Rev. 2012 Jul-Sep;14(3):159-67 – reference: 19494434 - J Alzheimers Dis. 2009;17(1):91-103 – reference: 19198593 - Nat Immunol. 2009 Mar;10(3):281-8 – reference: 8881749 - Immunology. 1996 Aug;88(4):501-7 – reference: 25614163 - Eur Respir J. 2015 Mar;45(3):790-806 – reference: 22365666 - Immunity. 2012 Feb 24;36(2):288-97 – reference: 25093579 - Immunology. 2015 Jan;144(1):1-10 – reference: 27304509 - Cell Metab. 2016 Jun 14;23 (6):1093-1112 – reference: 19805069 - Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17031-6 – reference: 23730304 - Front Immunol. 2013 May 20;4:121 – reference: 14962155 - J Am Geriatr Soc. 2004 Mar;52(3):399-404 – reference: 23938363 - Nat Rev Genet. 2013 Sep;14(9):601-7 – reference: 27521521 - Semin Cell Dev Biol. 2017 Jan;61:3-11 – reference: 25367574 - Immunity. 2014 Oct 16;41(4):605-19 – reference: 28392564 - Nat Rev Nephrol. 2017 Jun;13(6):368-380 – reference: 15647756 - Cell Death Differ. 2005 Feb;12 (2):177-83 – reference: 20179931 - Semin Immunopathol. 2010 Jun;32(2):95-106 – reference: 20686723 - Mol Biosyst. 2010 Oct;6(10):1983-92 – reference: 9720652 - Mech Ageing Dev. 1998 May 15;102(2-3):199-209 – reference: 28017881 - Ageing Res Rev. 2017 Jul;36:117-124 – reference: 25898983 - BMC Genomics. 2015 Apr 22;16:333 – reference: 18055696 - Genes Dev. 2007 Dec 15;21(24):3244-57 – reference: 27983788 - Anal Chem. 2017 Jan 17;89(2):1254-1259 – reference: 20701600 - Aging Cell. 2010 Oct;9(5):667-84 – reference: 12490960 - Nature. 2002 Dec 19-26;420(6917):868-74 – reference: 21668623 - Aging Cell. 2011 Oct;10(5):868-78 – reference: 18780874 - J Leukoc Biol. 2008 Dec;84(6):1454-61 – reference: 26773975 - Mech Ageing Dev. 2016 Sep;158:27-37 – reference: 22396894 - Aging Dis. 2011 Dec;2(6):449-65 – reference: 23056007 - Front Genet. 2012 Sep 25;3:189 – reference: 24055797 - Exp Gerontol. 2013 Dec;48(12):1379-86 – reference: 26580014 - Nature. 2015 Dec 3;528(7580):137-41 – reference: 16496121 - Diabetologia. 2006 Apr;49(4):744-7 – reference: 22830639 - Immun Ageing. 2012 Jul 25;9(1):15 – reference: 21772277 - Nat Immunol. 2011 Jul 19;12(8):689-94 – reference: 23506673 - Immun Ageing. 2013 Mar 19;10(1):11 – reference: 25367565 - Immunity. 2014 Oct 16;41(4):509-11 – reference: 26254232 - Brain Behav Immun. 2016 Jul;55:138-150 – reference: 26490707 - Nat Commun. 2015 Oct 22;6:8570 – reference: 26583116 - Biomed Res Int. 2015;2015:521957 – reference: 22302935 - Genes Dev. 2012 Feb 1;26(3):203-34 – reference: 15572589 - Blood. 2005 Mar 15;105(6):2294-9 – reference: 23385138 - Aging (Albany NY). 2013 Jan;5(1):18-36 – reference: 16750842 - Mech Ageing Dev. 2006 Aug;127(8):695-704 – reference: 23964277 - Front Immunol. 2013 Aug 06;4:231 – reference: 22466672 - Cell Mol Life Sci. 2012 May;69(10):1615-23 – reference: 17115046 - Nat Med. 2006 Dec;12(12):1365-71 – reference: 25792098 - Lancet Neurol. 2015 Apr;14(4):388-405 – reference: 26188489 - Clin Exp Med. 2016 Aug;16(3):257-63 – reference: 25761112 - PLoS One. 2015 Mar 11;10(3):e0116489 – reference: 25266669 - Eur J Immunol. 2014 Dec;44(12):3475-83 – reference: 20933612 - Ageing Res Rev. 2011 Jul;10(3):370-8 – reference: 14568895 - Circulation. 2003 Nov 11;108(19):2317-22 – reference: 16783459 - J Clin Immunol. 2006 May;26(3):193-203 – reference: 23812748 - Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11934-9 – reference: 26580010 - Nature. 2015 Dec 3;528(7580):44-6 – reference: 17870272 - Exp Gerontol. 2008 Feb;43(2):61-5 – reference: 21296109 - Biochim Biophys Acta. 2011 May;1813(5):878-88 – reference: 26109645 - J Immunol. 2015 Aug 1;195(3):944-52 – reference: 17606347 - Exp Gerontol. 2007 Aug;42(8):753-61 – reference: 27353257 - Ageing Res Rev. 2016 Aug;29:90-112 – reference: 22415616 - Age (Dordr). 2013 Jun;35(3):985-91 – reference: 7580284 - Int Arch Allergy Immunol. 1995 Nov;108(3):205-10 – reference: 26658771 - Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26 – reference: 27108521 - Nat Rev Immunol. 2016 Jun;16(6):367-77 – reference: 19878143 - Aging Cell. 2010 Feb;9(1):19-31 – reference: 23425777 - Aging (Albany NY). 2012 Dec;4(12):861-77 – reference: 23023500 - Nat Med. 2012 Oct;18(10):1518-24 – reference: 22936935 - Front Immunol. 2012 Aug 22;3:271 – reference: 27625432 - J Infect Dis. 2016 Oct 1;214 Suppl 2:S58-66 – reference: 19540259 - Mech Ageing Dev. 2009 Aug;130(8):509-17 – reference: 24819230 - PLoS One. 2014 May 12;9(5):e97171 – reference: 22395709 - Nat Med. 2012 Mar 06;18(3):363-74 – reference: 23717651 - PLoS One. 2013 May 22;8(5):e64702
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Snippet	Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The... The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including... Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time.The... Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The...
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SubjectTerms	Aging Aging - immunology Animals Cell activation Cellular Senescence - immunology Chronic illnesses Damage accumulation Health risks Humans immune dysregulation Immune system Immunoregulation Immunosenescence Inflammation inflamm‐aging Lymphocytes Lymphocytes T NF-kappa B - immunology NF-κB protein NF‐κB Older people Reviews Risk analysis Risk factors Subgroups T-Lymphocytes, Regulatory - immunology
Title	Human T cell immunosenescence and inflammation in aging
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