Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline‐enhanced prophylactic leprosy treatment
Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alt...
Saved in:
| Published in: | Clinical and translational science Vol. 17; no. 8; pp. e13861 - n/a |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
John Wiley & Sons, Inc
01.08.2024
John Wiley and Sons Inc Wiley |
| Subjects: | |
| ISSN: | 1752-8054, 1752-8062, 1752-8062 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE‐PEOPLE trial evaluating the safety of bedaquiline‐enhanced post‐exposure prophylaxis (bedaquiline and rifampicin, BE‐PEP, versus rifampicin, SDR‐PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post‐exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L‐ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L‐ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p < 0.001), with a strong correlation (r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L‐ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively (n = 636; p < 0.001), corresponding to moderate agreement (r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals. |
|---|---|
| AbstractList | Some anti-mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life-threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE-PEOPLE trial evaluating the safety of bedaquiline-enhanced post-exposure prophylaxis (bedaquiline and rifampicin, BE-PEP, versus rifampicin, SDR-PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post-exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L-ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L-ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p < 0.001), with a strong correlation (r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L-ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively (n = 636; p < 0.001), corresponding to moderate agreement (r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals.Some anti-mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life-threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE-PEOPLE trial evaluating the safety of bedaquiline-enhanced post-exposure prophylaxis (bedaquiline and rifampicin, BE-PEP, versus rifampicin, SDR-PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post-exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L-ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L-ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p < 0.001), with a strong correlation (r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L-ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively (n = 636; p < 0.001), corresponding to moderate agreement (r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals. Abstract Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE‐PEOPLE trial evaluating the safety of bedaquiline‐enhanced post‐exposure prophylaxis (bedaquiline and rifampicin, BE‐PEP, versus rifampicin, SDR‐PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post‐exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L‐ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L‐ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p < 0.001), with a strong correlation (r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L‐ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively (n = 636; p < 0.001), corresponding to moderate agreement (r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals. Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE‐PEOPLE trial evaluating the safety of bedaquiline‐enhanced post‐exposure prophylaxis (bedaquiline and rifampicin, BE‐PEP, versus rifampicin, SDR‐PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post‐exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L‐ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L‐ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p < 0.001), with a strong correlation (r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L‐ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively (n = 636; p < 0.001), corresponding to moderate agreement (r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals. Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE‐PEOPLE trial evaluating the safety of bedaquiline‐enhanced post‐exposure prophylaxis (bedaquiline and rifampicin, BE‐PEP, versus rifampicin, SDR‐PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post‐exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L‐ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L‐ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively ( p < 0.001), with a strong correlation ( r = 0.793). The mean absolute QTc difference between both modalities was 11 ± 10 ms. Mean manual and automated 12L‐ECG QTc were 394 ± 19 and 409 ± 19 ms, respectively ( n = 636; p < 0.001), corresponding to moderate agreement ( r = 0.655). The use of a mECG device for QT interval monitoring was feasible and yielded a median absolute QTc error of 8 ms. Automated QTc measurements were less accurate, yielding longer QTc intervals. |
| Author | Bergeman, Auke T. Assoumani, Younoussa Mzembaba, Aboubacar Hasker, Epco Tsoumanis, Achilleas Ortuño‐Gutiérrez, Nimer Loen, Harry Snijders, Rian Werf, Christian Nourdine, Said Hoof, Carolien Piubello, Alberto Braet, Sofie M. Jong, Bouke C. Salim, Zahara Grillone, Silahi H. Baco, Abdallah |
| AuthorAffiliation | 1 Department of Cardiology, Heart Centre, Amsterdam UMC location AMC University of Amsterdam Amsterdam The Netherlands 2 National Tuberculosis and Leprosy Control Program Moroni Comoros 4 Institute of Tropical Medicine Antwerp Belgium 3 Damien Foundation Brussels Belgium |
| AuthorAffiliation_xml | – name: 4 Institute of Tropical Medicine Antwerp Belgium – name: 2 National Tuberculosis and Leprosy Control Program Moroni Comoros – name: 1 Department of Cardiology, Heart Centre, Amsterdam UMC location AMC University of Amsterdam Amsterdam The Netherlands – name: 3 Damien Foundation Brussels Belgium |
| Author_xml | – sequence: 1 givenname: Auke T. orcidid: 0000-0002-3881-9105 surname: Bergeman fullname: Bergeman, Auke T. email: a.t.bergeman@amsterdamumc.nl organization: University of Amsterdam – sequence: 2 givenname: Said surname: Nourdine fullname: Nourdine, Said organization: National Tuberculosis and Leprosy Control Program – sequence: 3 givenname: Alberto surname: Piubello fullname: Piubello, Alberto organization: Damien Foundation – sequence: 4 givenname: Zahara surname: Salim fullname: Salim, Zahara organization: National Tuberculosis and Leprosy Control Program – sequence: 5 givenname: Sofie M. orcidid: 0000-0003-3291-8257 surname: Braet fullname: Braet, Sofie M. organization: Institute of Tropical Medicine – sequence: 6 givenname: Abdallah surname: Baco fullname: Baco, Abdallah organization: National Tuberculosis and Leprosy Control Program – sequence: 7 givenname: Silahi H. surname: Grillone fullname: Grillone, Silahi H. organization: National Tuberculosis and Leprosy Control Program – sequence: 8 givenname: Rian surname: Snijders fullname: Snijders, Rian organization: Institute of Tropical Medicine – sequence: 9 givenname: Carolien surname: Hoof fullname: Hoof, Carolien organization: Institute of Tropical Medicine – sequence: 10 givenname: Achilleas surname: Tsoumanis fullname: Tsoumanis, Achilleas organization: Institute of Tropical Medicine – sequence: 11 givenname: Harry orcidid: 0009-0000-4448-0526 surname: Loen fullname: Loen, Harry organization: Institute of Tropical Medicine – sequence: 12 givenname: Younoussa surname: Assoumani fullname: Assoumani, Younoussa organization: National Tuberculosis and Leprosy Control Program – sequence: 13 givenname: Aboubacar surname: Mzembaba fullname: Mzembaba, Aboubacar organization: National Tuberculosis and Leprosy Control Program – sequence: 14 givenname: Nimer surname: Ortuño‐Gutiérrez fullname: Ortuño‐Gutiérrez, Nimer organization: Damien Foundation – sequence: 15 givenname: Epco surname: Hasker fullname: Hasker, Epco organization: Institute of Tropical Medicine – sequence: 16 givenname: Christian orcidid: 0000-0001-8703-8527 surname: Werf fullname: Werf, Christian organization: University of Amsterdam – sequence: 17 givenname: Bouke C. orcidid: 0000-0002-1017-4675 surname: Jong fullname: Jong, Bouke C. organization: Institute of Tropical Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39075882$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1u1DAQgCNURH_gwAsgS1zgsK1_4sQ5IbSiUKkSQixna-KMd73K2ls7KcoBiUfgGXkSTFNWFAlf4sx8_jLxzGlx5IPHonjO6DnL68IM6ZwJVbFHxQmrJV8oWvGjw16Wx8VpSltKK1Ep-aQ4Fg2tpVL8pPh2iZBc63o3TAR8R8CYMYKZSLBkF3ICyacVcX7AeAt9Dnk3hOj8mqQhwoBrhymnSYsd3IzZ4_Hn9x_oN-ANdmQfw34z9WAGZ0iP-TVNZIgIww798LR4bKFP-Oz-eVZ8uXy3Wn5YXH98f7V8e70wZU3ZggkpsKzKlpdCdaWFRtbQdpwzidSyRrbALVVtU7a2EkaJuuxq2UhUtmwF4-KsuJq9XYCt3ke3gzjpAE7fBUJca4i5wh61aWwLoCB_I-u4BSNpy5S1llHF6yq73syu_djusDP5NyL0D6QPM95t9Drcasa4qppaZMOre0MMNyOmQe9cMtj34DGMSQuqqtzASqmMvvwH3YYx-nxXmWrqplGVKjP14u-SDrX8aXMGXs-AyfefItoDwqj-PUI6j5C-G6HMXszs19z76f-gXq4-zyd-AYtVywg |
| Cites_doi | 10.1136/bmj.39500.885752.BE 10.1155/2022/8652062 10.1111/anec.12872 10.1007/s12471-022-01716-5 10.1016/j.hrthm.2022.04.016 10.1136/postgradmedj-2020-138661 10.1161/CIRCULATIONAHA.109.192704 10.1016/S2214-109X(20)30396-X 10.2174/1573403X10666140514103612 10.1093/ehjdh/ztab083 |
| ContentType | Journal Article |
| Copyright | 2024 The Author(s). published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. 2024 The Author(s). Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 The Author(s). published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. – notice: 2024 The Author(s). Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. – notice: 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TK 7TM 7U9 7X7 7XB 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M7N M7P P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 5PM DOA |
| DOI | 10.1111/cts.13861 |
| DatabaseName | Wiley Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Local Electronic Collection Information Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | QT interval monitoring in leprosy treatment |
| EISSN | 1752-8062 |
| EndPage | n/a |
| ExternalDocumentID | oai_doaj_org_article_c9fbaa8aa9594b2fac50b18fff108276 PMC11286973 39075882 10_1111_cts_13861 CTS13861 |
| Genre | researchArticle Randomized Controlled Trial Clinical Trial, Phase II Journal Article |
| GeographicLocations | Comoro Islands |
| GeographicLocations_xml | – name: Comoro Islands |
| GroupedDBID | --- 05W 0R~ 10A 1OC 24P 29B 31~ 4.4 52S 53G 5GY 5VS 7X7 8-1 8FE 8FH 8FI 8FJ AAHHS AANHP AAZKR ABDBF ABUWG ACBWZ ACCFJ ACCMX ACRPL ACUHS ACXQS ACYXJ ADKYN ADNMO ADZMN ADZOD AEEZP AEQDE AFBPY AFKRA AFZJQ AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AVUZU BBNVY BDRZF BENPR BHPHI BPHCQ BRXPI BVXVI CAG CCPQU COF CS3 DIK EBD EBS EJD EMOBN ESX F5P FEDTE FYUFA G-S GODZA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IHR ITC KQ8 LH4 LK8 LW6 M7P MY~ O9- OIG OK1 P2P PIMPY PQQKQ PROAC QB0 ROL RPM SUPJJ SV3 TUS UKHRP WIN XG1 AAYXX AFFHD AGQPQ CITATION PHGZM PHGZT PQGLB CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TK 7TM 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c4701-1353e464b2438d4fa957abd2215e0f195ba2f08b94bf63c8374d7595e8f4b3123 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 0 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001280208900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1752-8054 1752-8062 |
| IngestDate | Mon Nov 10 04:31:06 EST 2025 Tue Nov 04 02:06:10 EST 2025 Fri Sep 05 11:24:09 EDT 2025 Sat Nov 29 14:25:50 EST 2025 Thu Apr 03 06:54:36 EDT 2025 Sat Nov 29 02:23:18 EST 2025 Wed Jan 22 17:14:45 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Attribution-NonCommercial 2024 The Author(s). Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4701-1353e464b2438d4fa957abd2215e0f195ba2f08b94bf63c8374d7595e8f4b3123 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0009-0000-4448-0526 0000-0001-8703-8527 0000-0003-3291-8257 0000-0002-3881-9105 0000-0002-1017-4675 |
| OpenAccessLink | https://doaj.org/article/c9fbaa8aa9594b2fac50b18fff108276 |
| PMID | 39075882 |
| PQID | 3097998684 |
| PQPubID | 2029979 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c9fbaa8aa9594b2fac50b18fff108276 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11286973 proquest_miscellaneous_3086062688 proquest_journals_3097998684 pubmed_primary_39075882 crossref_primary_10_1111_cts_13861 wiley_primary_10_1111_cts_13861_CTS13861 |
| PublicationCentury | 2000 |
| PublicationDate | August 2024 |
| PublicationDateYYYYMMDD | 2024-08-01 |
| PublicationDate_xml | – month: 08 year: 2024 text: August 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Clinical and translational science |
| PublicationTitleAlternate | Clin Transl Sci |
| PublicationYear | 2024 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2021; 9 2023; 31 2010; 121 2018 2021; 26 2008; 336 2021; 97 2022; 2022 2021; 2 2014; 10 2022; 19 e_1_2_11_7_1 e_1_2_11_6_1 e_1_2_11_4_1 e_1_2_11_3_1 e_1_2_11_2_1 World Health Organization. Regional Office for South‐East Asia (e_1_2_11_5_1) 2018 e_1_2_11_10_1 e_1_2_11_9_1 e_1_2_11_12_1 e_1_2_11_8_1 e_1_2_11_11_1 |
| References_xml | – volume: 26 issue: 6 year: 2021 article-title: Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6‐lead mobile ECG device and a standard 12‐lead ECG publication-title: Ann Noninvasive Electrocardiol – volume: 336 start-page: 761 issue: 7647 year: 2008 end-page: 764 article-title: Effectiveness of single dose rifampicin in preventing leprosy in close contacts of patients with newly diagnosed leprosy: cluster randomised controlled trial publication-title: BMJ – volume: 19 start-page: 1297 issue: 8 year: 2022 end-page: 1303 article-title: Risk of sudden cardiac death associated with QRS, QTc, and JTc intervals in the general population publication-title: Heart Rhythm – volume: 10 start-page: 287 issue: 3 year: 2014 end-page: 294 article-title: The measurement of the QT interval publication-title: Curr Cardiol Rev – volume: 121 start-page: 1047 issue: 8 year: 2010 end-page: 1060 article-title: Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation publication-title: Circulation – volume: 2 start-page: 643 issue: 4 year: 2021 end-page: 648 article-title: Clinical validation and evaluation of a novel six‐lead handheld electrocardiogram recorder compared to the 12‐lead electrocardiogram in unselected cardiology patients (EVALECG cardio) publication-title: Eur Heart J Digit Health – year: 2018 – volume: 31 start-page: 340 issue: 9 year: 2023 end-page: 347 article-title: Accuracy of mobile 6‐lead electrocardiogram device for assessment of QT interval: a prospective validation study publication-title: Neth Hear J – volume: 97 start-page: 452 issue: 1149 year: 2021 end-page: 458 article-title: Managing drug‐induced QT prolongation in clinical practice publication-title: Postgrad Med J – volume: 9 start-page: e81 issue: 1 year: 2021 end-page: e90 article-title: Leprosy post‐exposure prophylaxis with single‐dose rifampicin (LPEP): an international feasibility programme publication-title: Lancet Glob Health – volume: 2022 year: 2022 article-title: Leprosy: a review of epidemiology, clinical diagnosis, and management publication-title: J Trop Med – ident: e_1_2_11_4_1 doi: 10.1136/bmj.39500.885752.BE – ident: e_1_2_11_2_1 doi: 10.1155/2022/8652062 – ident: e_1_2_11_11_1 doi: 10.1111/anec.12872 – ident: e_1_2_11_7_1 doi: 10.1007/s12471-022-01716-5 – volume-title: Guidelines for the Diagnosis, Treatment and Prevention of Leprosy year: 2018 ident: e_1_2_11_5_1 – ident: e_1_2_11_10_1 doi: 10.1016/j.hrthm.2022.04.016 – ident: e_1_2_11_8_1 doi: 10.1136/postgradmedj-2020-138661 – ident: e_1_2_11_9_1 doi: 10.1161/CIRCULATIONAHA.109.192704 – ident: e_1_2_11_3_1 doi: 10.1016/S2214-109X(20)30396-X – ident: e_1_2_11_6_1 doi: 10.2174/1573403X10666140514103612 – ident: e_1_2_11_12_1 doi: 10.1093/ehjdh/ztab083 |
| SSID | ssj0063685 |
| Score | 2.3282866 |
| Snippet | Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest... Some anti-mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life-threatening ventricular arrhythmia. However, the highest... Abstract Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However,... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | e13861 |
| SubjectTerms | Accuracy Adult Arrhythmia Automation Diarylquinolines - administration & dosage Diarylquinolines - adverse effects Disease prevention Drug dosages Drug Therapy, Combination - methods EKG Electrocardiography Ethics Feasibility Studies Female Heart rate Humans Leprostatic Agents - administration & dosage Leprostatic Agents - adverse effects Leprosy Leprosy - diagnosis Leprosy - drug therapy Long QT Syndrome - chemically induced Long QT Syndrome - diagnosis Male Middle Aged Performance evaluation Prophylaxis Rifampin Rifampin - administration & dosage Rifampin - adverse effects Young Adult |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BQYgLb2igIIM4cAk4sZPYJwQVFReqIhapt8jPdqU2aTe7lfaAxE_gN_JLGHudhRWPC7ckdqKx5uHP9pcZgOfWVs6awufKozfx0lc59qS51VQ7yh1lmsZiE83-vjg8lAdpw21ItMoxJsZAbXsT9shfMRoOoEQt-Ouz8zxUjQqnq6mExmW4ErIksEjdOxgjcR2Sq8cfIiv0esQmKbNQYPKY-fCyYKIuNuajmLb_T1jzd8rkr1A2zkV7N_93FLfgRkKh5M3KbG7DJdfdgWsf0jn7XfiCyDDxZpdEdZYoYxYzZZak9-S0xwZHPk7INBIm8UOnMTKELUIyzMfkE9hMtLPqfDENWPb712-uO46EA4JSo3pP4g9a5MTh7bAka877Pfi8926y-z5PhRpywxta5KF2huM11yVnwnKvZNUobUtUiaO-kJVWpadCS659zQyuibltKlk54blmOHfeh62u79w2EO6ZK7mutaCWG0oVvsEL4RpZWsmtyeDZqK72bJWPox3XMajTNuo0g7dBkesOIYV2fNDPjtrkka2RXislFAqLcpVemYrqQnjvC4RFTZ3BzqjCNvn10P7UXwZP183okeGYRXWuX4Q-AleFZS1EBg9WVrOWhEmEaLioyUBs2NOGqJst3fQ4Zv1GYCxq2bAMXkTT-_vw293Jp3jx8N9DeATXS4RoKzrjDmzNZwv3GK6ai_l0mD2JrvQD-J0sWQ priority: 102 providerName: ProQuest – databaseName: Wiley Open Access dbid: 24P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5VBSEulHdTCjKIA5cgx3ESW5zaiooLVRGL1FvkJ12pTehmF2kPSPwEfiO_hLHzUFeAhMQtie1obM9nf2OPxwAvrS2cNZlPlUc0ceaLFHPS1GqqHeWO5prGyyaqkxNxdiZPt-DNeBamjw8xLbgFZMTxOgBc6e4ayM2ye53lIpg-NzJ8CPc2MH46DsNliKweT0MWCHkkJkNYoeDGMxXdmIxizP4_Ec3f_SWv89g4ER3v_FcV7sKdgX-Sg15h7sGWa-7DrffDDvsD-IaccPCYXRPVWKKMWS2UWZPWk8sWExz5MCPz6CqJP7qMY0JYHCTdcgw7gclEO6uuVvMg5M_vP1xzHl0NCFYbO_YiHs0iFw5fuzWZvN0fwqfjt7Ojd-lwRUNqeEWzNNya4XjJNeO5sNwrWVRKW4ZEwlGfyUIr5qnQkmtf5gatYW6rQhZOeK5znDUfwXbTNm4XCPe5Y1yXWlDLDaUKS_BMuEoyK7k1CbwY-6r-0kfiqEcLBhuyjg2ZwGHoxSlDCJ4dP7SLz_WAxdpIr5USCoVFuZhXpqA6E977DAlRVSawP-pAPSC6q3MaNkBFKXgCz6dkxGLYYFGNa1chj0B7kJVCJPC4V5lJklwiOUNzJgGxoUwbom6mNPPzGO8bKbEoZZUn8Cpq09-rXx_NPsaHvX_P-gRuMyRqvVPjPmwvFyv3FG6ar8t5t3gWMfULNsspbw priority: 102 providerName: Wiley-Blackwell |
| Title | Feasibility and accuracy of mobile QT interval monitoring strategies in bedaquiline‐enhanced prophylactic leprosy treatment |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcts.13861 https://www.ncbi.nlm.nih.gov/pubmed/39075882 https://www.proquest.com/docview/3097998684 https://www.proquest.com/docview/3086062688 https://pubmed.ncbi.nlm.nih.gov/PMC11286973 https://doaj.org/article/c9fbaa8aa9594b2fac50b18fff108276 |
| Volume | 17 |
| WOSCitedRecordID | wos001280208900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: DOA dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: M7P dateStart: 20160201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest - Health & Medical Complete保健、医学与药学数据库 customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: 7X7 dateStart: 20160201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: BENPR dateStart: 20160201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: PIMPY dateStart: 20160201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: WIN dateStart: 20080101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 1752-8062 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0063685 issn: 1752-8054 databaseCode: 24P dateStart: 20080101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BixAXxJtAWRnEgUvASZzEPtKqFT10FWARyynyU12pzdLNbqU9IPET-I38EsZOsuoKEBcuUZJxImce8TfxlzHAS2Nya3TiYukwmljq8hhb0tgoqixllmaKhsUmyvGYT6eiurLUl-eEdeWBO8W90cIpKbmUIhdMpU7qnKqEO-cSHL3KUGwbUc-QTHXv4MKXVQ-_QuYY74hK-ppCnsOjl-3rJONFsjUShYL9f0KZv5Mlr4LYMAod3YHbPXwkb7tu34VrtrkHN0_6CfL78A0hXU94XRPZGCK1Xi2kXpO5I-dzFFjyfkJmgemINzoPIe2_7ZF2OVSNQDFR1siL1cyD0J_ff9jmNDAFCHYc7XIW_qwiZxYP2zXZkNUfwKejw8nBu7hfYSHWrKRJ7Be9sKxAvbKMG-ZQyaVUJkUcYKlLRK5k6ihXqHlXZBqTWWbKXOSWO6YyHPQewk4zb-xjIMxlNmWqUJwapimVeAVLuC1FagQzOoIXg7brr10hjXpIQNAkdTBJBPveDpsGvvZ1OIEeUfceUf_LIyLYG6xY9wHZ1hn185e84CyC5xsxhpKfH5GNna98G47pXFpwHsGjzuibnmQCsRVmIxHwLXfY6uq2pJmdhnLdiGh5IcosglfBc_7--PXB5GPYefI_9PAUbqWIwDq24h7sLBcr-wxu6MvlrF2M4HrKKtyW0zJs-Qh29w_H1YdRiKSRJ8GifLc6Pqm-4NHn4_Evd_gnMQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3LbtQwFL2qCgI2vB-BAgaBxCbgOE7iLBCCQtWqDxUxSN2lftKR2qSdzIBmgcQn8CV8FF_CtScZGPHYdcEuiZ3ITo6vz42P7wV4ZExmjU5cLB2OJs5cFmNNGhtFlaXc0lTRkGyi2NkRe3vl7hJ86_fCeFllbxODoTaN9v_In6XUL0CJXPAXxyexzxrlV1f7FBozWGza6Sd02drnG6_x-z5mbO3NYHU97rIKxJoX6Dv7RA-W51wxngrDnSyzQirDcO6z1CVlpiRzVKiSK5enGh04boqszKxwXKWJD3SAJv8M0ggmglRwt7f8uQ_mHjZgZmhlkAt1kYy8ckiP26dJKvJkYf4LaQL-xG1_l2j-Sp3D3Ld26X97a5fhYseyycvZsLgCS7a-Cue2Ox3BNfiMzLfTBU-JrA2RWk9GUk9J48hRgwWWvB2QYRCE4oOOguXzv0BJO-6Da2AxUdbIk8nQc_XvX77a-iAIKgi-JYTvYdiARg4tnrZTMtf0X4f3p9L5G7BcN7W9BYS71DKuciWo4ZpSiXfwRNiiZKbkRkfwsIdHdTyLN1L1fhpiqAoYiuCVB868gg8RHi40ow9VZ3EqXTolpZDYWGwXc1JnVCXCOZcg7SvyCFZ6yFSd3Wqrn3iJ4MG8GC2OX0aStW0mvo5Ar5flQkRwc4bSeUvSEikoOm0RiAX8LjR1saQeHoSo5kj8RV4WaQRPAtT_3v1qdfAuHNz-dxfuw_n1wfZWtbWxs3kHLjCkozPp5gosj0cTexfO6o_jYTu6F4Yxgf3THgE_AANlhow |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3LbtQwFL2qCqrY8H4EChgEEptQJ3ESZ4EQtIyoCqNBDFJ3wU86Upu0kxnQLJD4BL6Hz-FLuHaSgRGPXRfsktiJ7OT4-tz4-F6AB1qnRqvIhsLiaGKxTUOsSUMtqTSUGZpI6pNN5MMh398vRmvwrd8L42SVvU30hlrXyv0j30qoW4DiGWdbtpNFjHYGT49PQpdByq209uk0WojsmcUndN-aJ7s7-K0fxvHgxXj7ZdhlGAgVy9GPdkkfDMuYjFnCNbOiSHMhdYzzoKE2KlIpYku5LJi0WaLQmWM6T4vUcMtkErmgB2j-z-QuaLmXDY76WSBzgd39ZswULQ7yoi6qkVMRqVnzOEp4Fq3MhT5lwJ947u9yzV9ptJ8HBxf-5zd4Ec537Js8a4fLJVgz1WXYeN3pC67AZ2TEnV54QUSliVBqPhVqQWpLjmosMOTNmEy8UBQfdOQtovs1SppZH3QDi4k0WpzMJ47Df__y1VQHXmhB8I0hrA_9xjRyaPC0WZCl1v8qvDuVzl-D9aquzA0gzCYmZjKTnGqmKBV4B4u4yYtYF0yrAO73UCmP2zgkZe-_IZ5Kj6cAnjsQLSu40OH-Qj39UHaWqFSFlUJwgY3FdsVWqJTKiFtrI6SDeRbAZg-fsrNnTfkTOwHcWxajJXLLS6Iy9dzV4egNxxnnAVxvEbtsSVIgNUVnLgC-guWVpq6WVJMDH-0cHQKeFXkSwCMP-793v9wev_UHN__dhbuwgcAvX-0O927BuRhZaqvo3IT12XRubsNZ9XE2aaZ3_Igm8P60B8APDy2PSQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Feasibility+and+accuracy+of+mobile+QT+interval+monitoring+strategies+in+bedaquiline%E2%80%90enhanced+prophylactic+leprosy+treatment&rft.jtitle=Clinical+and+translational+science&rft.au=Bergeman%2C+Auke+T.&rft.au=Nourdine%2C+Said&rft.au=Piubello%2C+Alberto&rft.au=Salim%2C+Zahara&rft.date=2024-08-01&rft.pub=John+Wiley+and+Sons+Inc&rft.issn=1752-8054&rft.eissn=1752-8062&rft.volume=17&rft.issue=8&rft_id=info:doi/10.1111%2Fcts.13861&rft.externalDocID=PMC11286973 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1752-8054&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1752-8054&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1752-8054&client=summon |