Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes

The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specif...

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Published in:Journal of virology Vol. 81; no. 9; p. 4904
Main Authors: Bihl, Florian, Narayan, Murli, Chisholm, 3rd, John V, Henry, Leah M, Suscovich, Todd J, Brown, Elizabeth E, Welzel, Tania M, Kaufmann, Daniel E, Zaman, Tauheed M, Dollard, Sheila, Martin, Jeff N, Wang, Fred, Scadden, David T, Kaye, Kenneth M, Brander, Christian
Format: Journal Article
Language:English
Published: United States 01.05.2007
Subjects:
Antigens, Viral - immunology
Epitopes - genetics
Herpesvirus 4, Human - immunology
Herpesvirus 8, Human - immunology
Humans
Immunity, Cellular - immunology
Immunologic Memory - immunology
Immunophenotyping
T-Lymphocytes - immunology
T-Lymphocytes - virology
Viral Proteins - genetics
ISSN:0022-538X
Online Access:Get more information
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Summary:The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
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ISSN:0022-538X
DOI:10.1128/JVI.02509-06