Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage
Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavon...
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| Vydáno v: | Frontiers in pharmacology Ročník 14; s. 1221486 |
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| Jazyk: | angličtina |
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01.08.2023
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| ISSN: | 1663-9812, 1663-9812 |
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| Abstract | Herein, we explored the protective effect of
Leonotis ocymifolia
(Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their
O
- and
C
-glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The
in vivo
results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that
L. ocymifolia
extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time. |
|---|---|
| AbstractList | Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their O- and C-glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The in vivo results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that L. ocymifolia extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time.Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their O- and C-glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The in vivo results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that L. ocymifolia extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time. Herein, we explored the protective effect of (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their - and -glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time. Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their O- and C-glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The in vivo results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that L. ocymifolia extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time. Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled their phytocontents. A total of 31 compounds belonging to organic and phenolic acids and their glycosides as well as flavonoids and their O - and C -glycosides were identified through LC-MS/MS. The DPPH and FRAP assays revealed that the extract had powerful antioxidant properties. The in vivo results demonstrated that administering LO extract for 30 days (40 and 80 mg/kg b. w.) significantly improved the altered renal injury markers via reducing creatinine (high dose only) and uric acid levels compared to the Cp-group. The deleterious action of cisplatin on renal oxidative stress markers (GSH, MDA, SOD, and CAT) were also mitigated by LO-pretreatment. The reduction of the inflammatory marker (IL-6), and inhibition of DNA fragmentation, highlighted the prophylactic action of LO in kidney tissue. Molecular docking followed by a 100 ns molecular dynamic simulation analyses revealed that, amongst the 31 identified compounds in LO, chlorogenic and caffeoylmalic acids had the most stable binding to IL-6. The nephroprotective effects were further confirmed by histopathological observations, which showed improvement in ultrastructural changes induced by cisplatin. The observed findings reinforce the conclusion that L. ocymifolia extract exerts nephroprotective properties, which could be related to its antioxidant and anti-inflammatory activities. Further studies are required to determine the therapeutic doses and the proper administration time. |
| Author | Ibrahim, Mohammed Auwal Ouchari, Wafae Tlili, Nizar Mufti, Afoua Mahmoud, Mona F. Sobeh, Mansour Feriani, Anouar Mandour, Yasmine M. |
| AuthorAffiliation | 5 Department of Biochemistry , Ahmadu Bello University , Zaria , Nigeria 2 AgroBioSciences Program , College for Sustainable Agriculture and Environmental Science , Mohammed VI Polytechnic University , Ben Guerir , Morocco 6 Department of Pharmacology and Toxicology , Faculty of Pharmacy , Zagazig University , Zagazig , Egypt 4 Institut Supérieur des Sciences et Technologies de L’Environnement , Université de Carthage , Carthage , Tunisia 1 Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems , Faculty of Sciences of Gafsa , University of Gafsa , Gafsa , Tunisia 3 School of Life and Medical Sciences , University of Hertfordshire Hosted By Global Academic Foundation , Cairo , Egypt |
| AuthorAffiliation_xml | – name: 4 Institut Supérieur des Sciences et Technologies de L’Environnement , Université de Carthage , Carthage , Tunisia – name: 1 Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems , Faculty of Sciences of Gafsa , University of Gafsa , Gafsa , Tunisia – name: 3 School of Life and Medical Sciences , University of Hertfordshire Hosted By Global Academic Foundation , Cairo , Egypt – name: 6 Department of Pharmacology and Toxicology , Faculty of Pharmacy , Zagazig University , Zagazig , Egypt – name: 2 AgroBioSciences Program , College for Sustainable Agriculture and Environmental Science , Mohammed VI Polytechnic University , Ben Guerir , Morocco – name: 5 Department of Biochemistry , Ahmadu Bello University , Zaria , Nigeria |
| Author_xml | – sequence: 1 givenname: Afoua surname: Mufti fullname: Mufti, Afoua – sequence: 2 givenname: Anouar surname: Feriani fullname: Feriani, Anouar – sequence: 3 givenname: Wafae surname: Ouchari fullname: Ouchari, Wafae – sequence: 4 givenname: Yasmine M. surname: Mandour fullname: Mandour, Yasmine M. – sequence: 5 givenname: Nizar surname: Tlili fullname: Tlili, Nizar – sequence: 6 givenname: Mohammed Auwal surname: Ibrahim fullname: Ibrahim, Mohammed Auwal – sequence: 7 givenname: Mona F. surname: Mahmoud fullname: Mahmoud, Mona F. – sequence: 8 givenname: Mansour surname: Sobeh fullname: Sobeh, Mansour |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37593171$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jep_2024_119225 crossref_primary_10_3390_antibiotics14030238 crossref_primary_10_3390_diseases13050140 crossref_primary_10_1016_j_fbio_2025_106749 |
| Cites_doi | 10.1152/ajprenal.2000.278.1.F52 10.1016/j.lfs.2022.120845 10.1007/s00210-023-02559-6 10.1007/s11906-016-0668-z 10.1016/j.fct.2013.09.003 10.1016/S0022-2836(95)80037-9 10.1016/j.arabjc.2022.104037 10.1038/s41401-021-00620-9 10.1101/cshperspect.a016295 10.1002/cphy.c100030 10.1016/j.redox.2018.01.012 10.1517/17460441.2015.1032936 10.3390/bios12090718 10.1016/s0076-6879(84)05016-3 10.1039/D2FO01165D 10.1007/s00204-006-0173-2 10.1016/j.fct.2009.03.043 10.1093/ckj/sfy128 10.1016/j.phymed.2018.09.210 10.1186/s12929-019-0518-9 10.1021/ct400341p 10.1016/0003-2697(68)90092-4 10.1007/s10863-006-9059-5 10.1073/pnas.93.11.5495 10.1016/j.pharep.2015.04.002 10.1681/ASN.V103635 10.1016/0263-7855(96)00018-5 10.1016/j.tox.2006.11.073 10.1021/ct300418h 10.3390/molecules28031036 10.1097/MAJ.0b013e31812dfe1e 10.1046/j.1523-1755.2001.00048.x 10.1006/jmbi.1996.0897 10.3390/molecules28031302 10.1021/np50113a017 10.1002/3527608001.ch19 10.1111/j.1432-1033.1974.tb03714.x 10.1096/fj.202000180RR 10.1080/10412905.2007.9699314 10.1634/theoncologist.2010-S3-03 10.3389/fmed.2022.873739 10.1038/s41580-020-0230-3 10.1038/srep37716 10.1161/HYPERTENSIONAHA.118.10884 10.1117/1.JBO.21.3.037001 10.1080/07391102.2020.1837680 10.1016/j.ijpharm.2010.09.035 10.1182/blood.v89.4.1319 10.1016/j.jep.2011.04.063 10.1152/physrev.00031.2007 10.1016/s0076-6879(78)52032-6 10.1016/j.biopha.2019.108600 10.1007/s40620-017-0392-z 10.1016/S0022-2143(03)00111-2 10.1111/jphp.12843 10.1016/j.jff.2017.12.055 10.1002/mrc.1136 10.1681/ASN.2006101108 10.1186/1756-8722-4-35 10.1016/j.fct.2014.02.002 10.1681/ASN.2010080796 |
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| Keywords | antioxidant nephroprotective Leonotis ocymifolia oxidative stress DNA fragmentation |
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Leonotis ocymifolia
(Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in... Herein, we explored the protective effect of (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in rats and profiled... Herein, we explored the protective effect of Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts extract (LO) against cisplatin (CP)-induced nephrotoxicity in... |
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| Title | Leonotis ocymifolia (Burm.f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage |
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