Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence

The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI stage, though, is easily diagnosed by vascular injuries and rep...

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Veröffentlicht in:Frontiers in aging neuroscience Jg. 15; S. 1073039
Hauptverfasser: Liu, Qiuping, Zhang, Xuezhu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Media S.A 15.03.2023
Schlagworte:
Aging Neuroscience
arterial spin labeled perfusion imaging
diffusion tensor imaging
multimodal neuroimaging
resting-state functional magnetic resonance imaging
vascular mild cognitive impairment
resting-state functional magnetic resonance imaging
multimodal neuroimaging
vascular mild cognitive impairment
diffusion tensor imaging
arterial spin labeled perfusion imaging
ISSN:1663-4365, 1663-4365
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Abstract The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI stage, though, is easily diagnosed by vascular injuries and represents a high-risk period for the future decline of patients’ cognitive functions. The existing studies in China and abroad have found that magnetic resonance imaging technology can provide imaging markers related to the occurrence and development of VaMCI, which is an important tool for detecting the changes in microstructure and function of VaMCI patients. Nevertheless, most of the existing studies evaluate the information of a single modal image. Due to the different imaging principles, the data provided by a single modal image are limited. In contrast, multi-modal magnetic resonance imaging research can provide multiple comprehensive data such as tissue anatomy and function. Here, a narrative review of published articles on multimodality neuroimaging in VaMCI diagnosis was conducted，and the utilization of certain neuroimaging bio-markers in clinical applications was narrated. These markers include evaluation of vascular dysfunction before tissue damages and quantification of the extent of network connectivity disruption. We further provide recommendations for early detection, progress, prompt treatment response of VaMCI, as well as optimization of the personalized treatment plan.
AbstractList The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI stage, though, is easily diagnosed by vascular injuries and represents a high-risk period for the future decline of patients’ cognitive functions. The existing studies in China and abroad have found that magnetic resonance imaging technology can provide imaging markers related to the occurrence and development of VaMCI, which is an important tool for detecting the changes in microstructure and function of VaMCI patients. Nevertheless, most of the existing studies evaluate the information of a single modal image. Due to the different imaging principles, the data provided by a single modal image are limited. In contrast, multi-modal magnetic resonance imaging research can provide multiple comprehensive data such as tissue anatomy and function. Here, a narrative review of published articles on multimodality neuroimaging in VaMCI diagnosis was conducted，and the utilization of certain neuroimaging bio-markers in clinical applications was narrated. These markers include evaluation of vascular dysfunction before tissue damages and quantification of the extent of network connectivity disruption. We further provide recommendations for early detection, progress, prompt treatment response of VaMCI, as well as optimization of the personalized treatment plan.
The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI stage, though, is easily diagnosed by vascular injuries and represents a high-risk period for the future decline of patients' cognitive functions. The existing studies in China and abroad have found that magnetic resonance imaging technology can provide imaging markers related to the occurrence and development of VaMCI, which is an important tool for detecting the changes in microstructure and function of VaMCI patients. Nevertheless, most of the existing studies evaluate the information of a single modal image. Due to the different imaging principles, the data provided by a single modal image are limited. In contrast, multi-modal magnetic resonance imaging research can provide multiple comprehensive data such as tissue anatomy and function. Here, a narrative review of published articles on multimodality neuroimaging in VaMCI diagnosis was conducted，and the utilization of certain neuroimaging bio-markers in clinical applications was narrated. These markers include evaluation of vascular dysfunction before tissue damages and quantification of the extent of network connectivity disruption. We further provide recommendations for early detection, progress, prompt treatment response of VaMCI, as well as optimization of the personalized treatment plan.The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI stage, though, is easily diagnosed by vascular injuries and represents a high-risk period for the future decline of patients' cognitive functions. The existing studies in China and abroad have found that magnetic resonance imaging technology can provide imaging markers related to the occurrence and development of VaMCI, which is an important tool for detecting the changes in microstructure and function of VaMCI patients. Nevertheless, most of the existing studies evaluate the information of a single modal image. Due to the different imaging principles, the data provided by a single modal image are limited. In contrast, multi-modal magnetic resonance imaging research can provide multiple comprehensive data such as tissue anatomy and function. Here, a narrative review of published articles on multimodality neuroimaging in VaMCI diagnosis was conducted，and the utilization of certain neuroimaging bio-markers in clinical applications was narrated. These markers include evaluation of vascular dysfunction before tissue damages and quantification of the extent of network connectivity disruption. We further provide recommendations for early detection, progress, prompt treatment response of VaMCI, as well as optimization of the personalized treatment plan.
Author Liu, Qiuping
Zhang, Xuezhu
AuthorAffiliation 3 Tianjin University of Traditional Chinese Medicine , Tianjin , China
2 National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion , Tianjin , China
1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin , China
AuthorAffiliation_xml – name: 3 Tianjin University of Traditional Chinese Medicine , Tianjin , China
– name: 2 National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion , Tianjin , China
– name: 1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin , China
Author_xml – sequence: 1
  givenname: Qiuping
  surname: Liu
  fullname: Liu, Qiuping
– sequence: 2
  givenname: Xuezhu
  surname: Zhang
  fullname: Zhang, Xuezhu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37009448$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_3389_fneur_2024_1421283
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Keywords resting-state functional magnetic resonance imaging
multimodal neuroimaging
vascular mild cognitive impairment
diffusion tensor imaging
arterial spin labeled perfusion imaging
Language English
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Reviewed by: Mario Mascalchi, University of Florence, Italy; Nesrine Salah El Dine El Sayed, Cairo University, Egypt
Edited by: Shuo Wang, Capital Medical University, China
This article was submitted to Neurocognitive Aging and Behavior, a section of the journal Frontiers in Aging Neuroscience
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Snippet The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused...
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SubjectTerms Aging Neuroscience
arterial spin labeled perfusion imaging
diffusion tensor imaging
multimodal neuroimaging
resting-state functional magnetic resonance imaging
vascular mild cognitive impairment
Title Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence
URI https://www.ncbi.nlm.nih.gov/pubmed/37009448
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Volume 15
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