Significant up-regulation of lncRNAs in neuromyelitis optica spectrum disorder

Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating defect. Long non-coding RNAs (lncRNAs) might influence the pathobiology and progression of NMOSD. The current study assessed expression level of NEAT1, PANDAR, MEG3 and TUG1 lncRNAs in the peripheral blood of NMOSD pat...

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Bibliographic Details
Published in:Scientific reports Vol. 13; no. 1; pp. 18692 - 8
Main Authors: Taheri, Mohammad, Sadeghi, Ahmad, Gharebaghi, Alireza, Ghiasian, Masoud, Eslami, Solat, Khalilian, Sheyda, Sayad, Arezou, Ghafouri-Fard, Soudeh
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 31.10.2023
Nature Publishing Group
Nature Portfolio
Subjects:
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692/617
Brain research
Consent
Demyelination
Disease
Ethics
Females
Gender
Gene expression
Humanities and Social Sciences
Immunology
Medical research
multidisciplinary
Neuromyelitis
Non-coding RNA
Overexpression
Peripheral blood
Research centers
RNA polymerase
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Neuromyelitis optica spectrum disorder (NMOSD) is an immune-related demyelinating defect. Long non-coding RNAs (lncRNAs) might influence the pathobiology and progression of NMOSD. The current study assessed expression level of NEAT1, PANDAR, MEG3 and TUG1 lncRNAs in the peripheral blood of NMOSD patients compared with healthy individuals. All mentioned lncRNAs were shown to be over-expressed in total NMOSD cases, male NMOSD cases and female NMOSD cases compared with the matching control subgroups. MEG3 had the most robust over-expression in patients subgroups compared with normal subjects. There was no noteworthy difference in the expression of any of lncRNAs between female and male patients. MEG3 had an ideal performance in the differentiation of NMOSD cases from healthy persons (Sensitivity and specificity values = 100%). Other lncRNAs could also efficiently separate NMOSD cases from control subjects (AUC values = 0.97, 0.89 and 0.88 for PANDAR, NEAT1 and TUG1, respectively). Cumulatively, NEAT1, PANDAR, MEG3 and TUG1 lncRNAs can be considered as appropriate disease markers for NMOSD.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-45457-w