Functional dysconnectivity of the limbic loop of frontostriatal circuits in first‐episode, treatment‐naive schizophrenia

Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ‐related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology...

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Vydané v:	Human brain mapping Ročník 39; číslo 2; s. 747 - 757
Hlavní autori:	Lin, Pan, Wang, Xiaosheng, Zhang, Bei, Kirkpatrick, Brian, Öngür, Dost, Levitt, James J., Jovicich, Jorge, Yao, Shuqiao, Wang, Xiang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States John Wiley & Sons, Inc 01.02.2018 John Wiley and Sons Inc
Predmet:	Brain - diagnostic imaging Brain - physiopathology Brain Mapping Case-Control Studies Circuits Cortex (cingulate) Cross-Sectional Studies Error correction Error detection Etiology Female Functional magnetic resonance imaging Humans Magnetic resonance imaging Male Mental disorders Neostriatum Neural Pathways - diagnostic imaging Neural Pathways - physiopathology Nucleus accumbens Patients Psychiatric Status Rating Scales Psychopathology Rest Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Seeds Sensorimotor system Subdivisions Young Adult dorsal anterior cingulate cortex resting-state functional connectivity ventral striatum first-episode schizophrenia frontostriatal circuits
ISSN:	1065-9471, 1097-0193, 1097-0193
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Shrnutí:	Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ‐related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first‐episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case–control, cross‐sectional study was conducted, wherein resting‐state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment‐naïve FESZ patients and 29 healthy control (HC) subjects. Seed‐based FC analyses were performed by placing six bilateral pairs of seeds within a priori defined subdivisions of the striatum. We observed significantly decreased FC for the FESZ group relative to the HC group [ p < .05, family‐wise error (FWE)‐corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry. Moreover, bilaterally decreased inferior ventral striatum/nucleus accumbens (VSi)‐dorsal anterior cingulate cortex (dACC) FC within the limbic loop correlated inversely with overall FESZ symptom severity and the disorganization factor score of PANSS. These findings provide new insight into the role of frontostriatal limbic loop hypoconnectivity in early‐stage schizophrenia pathology and suggest potential novel therapeutic targets.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Pan Lin and Xiaosheng Wang contributed equally to this work. Funding information National Natural Science Foundation of China, Grant/Award Number: 31671144, 61473221, 81471104; New Century Excellent Talents in University at the Chinese Ministry of Education, Grant/Award Number: NCET‐12‐0557
ISSN:	1065-9471 1097-0193 1097-0193
DOI:	10.1002/hbm.23879