Functional dysconnectivity of the limbic loop of frontostriatal circuits in first‐episode, treatment‐naive schizophrenia

Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ‐related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology...

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Published in:Human brain mapping Vol. 39; no. 2; pp. 747 - 757
Main Authors: Lin, Pan, Wang, Xiaosheng, Zhang, Bei, Kirkpatrick, Brian, Öngür, Dost, Levitt, James J., Jovicich, Jorge, Yao, Shuqiao, Wang, Xiang
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.02.2018
John Wiley and Sons Inc
Subjects:
Brain - diagnostic imaging
Brain - physiopathology
Brain Mapping
Case-Control Studies
Circuits
Cortex (cingulate)
Cross-Sectional Studies
Error correction
Error detection
Etiology
Female
Functional magnetic resonance imaging
Humans
Magnetic resonance imaging
Male
Mental disorders
Neostriatum
Neural Pathways - diagnostic imaging
Neural Pathways - physiopathology
Nucleus accumbens
Patients
Psychiatric Status Rating Scales
Psychopathology
Rest
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Seeds
Sensorimotor system
Subdivisions
Young Adult
dorsal anterior cingulate cortex
resting-state functional connectivity
ventral striatum
first-episode schizophrenia
frontostriatal circuits
ISSN:1065-9471, 1097-0193, 1097-0193
Online Access:Get full text
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Summary:Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ‐related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first‐episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case–control, cross‐sectional study was conducted, wherein resting‐state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment‐naïve FESZ patients and 29 healthy control (HC) subjects. Seed‐based FC analyses were performed by placing six bilateral pairs of seeds within a priori defined subdivisions of the striatum. We observed significantly decreased FC for the FESZ group relative to the HC group [ p  < .05, family‐wise error (FWE)‐corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry. Moreover, bilaterally decreased inferior ventral striatum/nucleus accumbens (VSi)‐dorsal anterior cingulate cortex (dACC) FC within the limbic loop correlated inversely with overall FESZ symptom severity and the disorganization factor score of PANSS. These findings provide new insight into the role of frontostriatal limbic loop hypoconnectivity in early‐stage schizophrenia pathology and suggest potential novel therapeutic targets.
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Pan Lin and Xiaosheng Wang contributed equally to this work.
Funding information National Natural Science Foundation of China, Grant/Award Number: 31671144, 61473221, 81471104; New Century Excellent Talents in University at the Chinese Ministry of Education, Grant/Award Number: NCET‐12‐0557
ISSN:1065-9471
1097-0193
1097-0193
DOI:10.1002/hbm.23879