Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control
To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. CT stimulation was conducted under voluntary b...
Saved in:
| Published in: | Radiotherapy and oncology Vol. 102; no. 1; pp. 56 - 61 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Ireland
Elsevier Ireland Ltd
01.01.2012
|
| Subjects: | |
| ISSN: | 0167-8140, 1879-0887, 1879-0887 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system.
CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position.
Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5months (range: 3.5–40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27–100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1year overall survival rate is 71.7% and median survival time is 17.2months (3.5–40.7months).
Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. |
|---|---|
| AbstractList | To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system.
CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position.
Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5months (range: 3.5–40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27–100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1year overall survival rate is 71.7% and median survival time is 17.2months (3.5–40.7months).
Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months). Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system.PURPOSETo implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system.CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position.MATERIALS AND METHODSCT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position.Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months).RESULTSThirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5-40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27-100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5-40.7 months).Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system.CONCLUSIONSExcellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. Abstract Purpose To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients treated with high dose conformal radiotherapy using a commercially available treatment system. Materials and methods CT stimulation was conducted under voluntary breath hold or gating using the Varian Real-time Position Management™ (RPM) System. Treatments were delivered daily under kV image guidance to verify the diaphragmatic or lipiodol-defined tumor position. Results Thirty-three patients with liver confined hepatocellular carcinoma were treated between May 2006 and Dec 2009. After a median follow-up period of 16.5 months (range: 3.5–40.7), all but 2 patients demonstrated radiological tumor regression. Eight patients (24%) achieved complete remission. The median tumor shrinkage was 42% (27–100%). Subsequent in-field tumor progression was observed in only three patients (10%). For the 23 patients with abnormal alpha fetoprotein level, 22 of them showed biochemical response with a median AFP level drop of 78%. The treatment was well tolerated: Grade 3 toxicities occurred in 5 patients (1 leucopenia, 1 elevated liver enzyme and 3 elevated bilirubin level) but there was no grade 4 toxicity or treatment related death. The 1 year overall survival rate is 71.7% and median survival time is 17.2 months (3.5–40.7 months). Conclusions Excellent treatment results with minimal toxicities could be achieved in a clinical environment with a commercially available highly sophisticated radiotherapy system. |
| Author | Lee, Anne W.M. Lee, Michael C.H. Law, Ada L.Y. Fung, Kai-Hung Li, Francis Lao, Wai-Cheung Ng, Wai-Tong Chan, Augustine T.S. |
| Author_xml | – sequence: 1 givenname: Ada L.Y. surname: Law fullname: Law, Ada L.Y. email: lawly@ha.org.hk organization: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 2 givenname: Wai-Tong surname: Ng fullname: Ng, Wai-Tong organization: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 3 givenname: Michael C.H. surname: Lee fullname: Lee, Michael C.H. organization: Department of Medical Physics, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 4 givenname: Augustine T.S. surname: Chan fullname: Chan, Augustine T.S. organization: Department of Diagnostic Radiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 5 givenname: Kai-Hung surname: Fung fullname: Fung, Kai-Hung organization: Department of Diagnostic Radiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 6 givenname: Francis surname: Li fullname: Li, Francis organization: Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 7 givenname: Wai-Cheung surname: Lao fullname: Lao, Wai-Cheung organization: Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China – sequence: 8 givenname: Anne W.M. surname: Lee fullname: Lee, Anne W.M. organization: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, People’s Republic of China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21640423$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVkkuLFDEUhYOMOD2j_0AkO1dVJunUIyLCMPiCAReO65BKbnWnJ5W0Saql_70punUhyODm3s0558J37hW68MEDQi8pqSmh7ZtdHZUJXteMUFqTpiaMPUEr2neiIn3fXaBVkXVVTzm5RFcp7QghjKy7Z-iS0ZYTztYrlO8jqDyBzziMeB_tpOIRO3uAiLXyuqw5Wb_BW7vZumOlgx9DnJTD5boNeQtR7Y_4p81b_HCoin0DeDNbs3ix8gZHSHsbVQ4lt7hzDO45ejoql-DFeV-j7x8_3N9-ru6-fvpye3NXad6KXCZvDePajP3YMUFGGJhgAwHB9Ti0PTPNMAy0HcUgTNe1DQEmNDW8AehVz9fX6PUpdx_DjxlSlpNNGpxTHsKcpKCsE23Hm6J8dVbOwwRGnkHI36CKgJ8EOoaUIox_JJTIpQ-5k6c-5NKHJI0sfRTb279s2maV7cJBWfeY-f3JDIXRwUKUSVsoXI2NoLM0wf5vgHbWW63cAxwh7cIcfeEvqUxMEvlt-ZflXSgtn0KbBcu7fwc8fv8X-qvUZA |
| CitedBy_id | crossref_primary_10_1016_j_ijrobp_2020_11_036 crossref_primary_10_1016_j_radonc_2015_04_006 crossref_primary_10_1007_s13566_013_0124_5 crossref_primary_10_1016_j_radonc_2011_11_007 crossref_primary_10_1002_mp_13384 crossref_primary_10_1016_j_radonc_2013_11_007 crossref_primary_10_1016_j_radonc_2017_03_004 crossref_primary_10_1016_j_ijrobp_2015_04_016 crossref_primary_10_1002_acm2_12887 crossref_primary_10_1118_1_4870385 crossref_primary_10_1016_j_tipsro_2023_100223 crossref_primary_10_1002_acm2_12008 crossref_primary_10_1186_s12885_020_07082_y crossref_primary_10_1016_j_radonc_2011_12_008 crossref_primary_10_1016_j_radonc_2017_02_010 crossref_primary_10_3892_mco_2014_304 crossref_primary_10_3389_fonc_2022_819905 crossref_primary_10_1186_s13014_017_0818_8 crossref_primary_10_1002_acm2_12220 crossref_primary_10_1118_1_3678986 crossref_primary_10_1159_000367728 crossref_primary_10_1016_j_radonc_2015_02_022 crossref_primary_10_3109_0284186X_2015_1062134 |
| Cites_doi | 10.1053/jhep.2002.33156 10.1016/S0360-3016(00)00462-4 10.1016/j.radonc.2008.06.001 10.1080/02841860600897934 10.1002/(SICI)1097-0142(19960601)77:11<2217::AID-CNCR6>3.0.CO;2-M 10.1200/JCO.2000.18.11.2210 10.1200/JCO.2005.01.5354 10.1016/j.radonc.2007.11.015 10.1016/j.ijrobp.2006.10.035 10.1118/1.598837 10.1016/j.semradonc.2005.04.005 10.1016/S0360-3016(01)01815-6 10.1016/S0360-3016(02)03941-X 10.1016/j.ijrobp.2006.06.015 10.1200/JCO.1993.11.7.1286 10.1177/028418518402500208 10.1016/S0360-3016(02)03929-9 10.1080/02841860600936369 10.1016/j.radonc.2010.03.025 10.1016/j.radonc.2010.10.014 10.3748/wjg.v10.i15.2184 10.1056/NEJMoa0708857 10.1016/S0360-3016(02)02846-8 10.1097/01.coc.0000184657.65679.6f 10.1016/S0360-3016(00)00625-8 10.1016/S0140-6736(02)08649-X 10.1097/00130404-200409000-00008 10.1016/j.ijrobp.2006.10.007 10.1097/00000658-200107000-00010 10.1097/01.COC.0000077936.97997.AB |
| ContentType | Journal Article |
| Copyright | 2011 Elsevier Ireland Ltd Elsevier Ireland Ltd Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
| Copyright_xml | – notice: 2011 Elsevier Ireland Ltd – notice: Elsevier Ireland Ltd – notice: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.radonc.2011.05.022 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1879-0887 |
| EndPage | 61 |
| ExternalDocumentID | 21640423 10_1016_j_radonc_2011_05_022 S0167814011002155 1_s2_0_S0167814011002155 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABMAC ABMZM ABOCM ABUDA ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 E3Z EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HED HMK HMO HVGLF HZ~ IHE J1W J5H KOM M27 M41 MO0 N9A O-L O9- OAUVE OC~ OO- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SDF SDG SEL SES SEW SPCBC SSH SSU SSZ T5K UV1 WUQ X7M Z5R ZGI ZXP ~G- ~HD 0SF AACTN AFCTW AFKWA AJOXV AMFUW RIG AAIAV ABLVK ABYKQ AHPSJ AJBFU LCYCR NCXOZ 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c469t-c446d24cdf8f7290feb292b0e94cfb682d5bbb16f9b9d77650e29c1d45ee8a843 |
| ISICitedReferencesCount | 31 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000300654700010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0167-8140 1879-0887 |
| IngestDate | Sun Sep 28 01:45:38 EDT 2025 Thu Apr 03 06:57:01 EDT 2025 Sat Nov 29 03:33:35 EST 2025 Tue Nov 18 22:32:39 EST 2025 Fri Feb 23 02:34:16 EST 2024 Sun Feb 23 10:19:31 EST 2025 Tue Oct 14 19:29:52 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Hepatocellular Liver neoplasm Liver cancer Carcinoma Image-guided radiotherapy Respiratory control Radiotherapy |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c469t-c446d24cdf8f7290feb292b0e94cfb682d5bbb16f9b9d77650e29c1d45ee8a843 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 21640423 |
| PQID | 912796745 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_912796745 pubmed_primary_21640423 crossref_primary_10_1016_j_radonc_2011_05_022 crossref_citationtrail_10_1016_j_radonc_2011_05_022 elsevier_sciencedirect_doi_10_1016_j_radonc_2011_05_022 elsevier_clinicalkeyesjournals_1_s2_0_S0167814011002155 elsevier_clinicalkey_doi_10_1016_j_radonc_2011_05_022 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-01-01 |
| PublicationDateYYYYMMDD | 2012-01-01 |
| PublicationDate_xml | – month: 01 year: 2012 text: 2012-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Radiotherapy and oncology |
| PublicationTitleAlternate | Radiother Oncol |
| PublicationYear | 2012 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Beddar, Kainz, Briere (b0045) 2007; 67 Balter, Brock, Litzenberg (b0055) 2002; 52 Molinelli, de Pooter, Mendez Romero (b0140) 2008; 87 Shirato, Shimizu, Kitamura (b0130) 2000; 48 Imada, Kato, Yasuda (b0040) 2010; 96 Lo, Ngan, Tso (b0020) 2002; 35 Poon, Fan, Lo (b0005) 2001; 234 Seong, Park, Han, Chon (b0075) 2003; 55 Kelsey, Schefter, Nash (b0050) 2005; 28 Liang, Huang, Zhu (b0035) 2011; 98 Ben-Josef, Normolle, Ensminger (b0070) 2005; 23 de Pooter, Mendez Romero, Wunderink, Storchi, Heijmen (b0150) 2008; 88 Mornex, Girard, Beziat (b0115) 2006; 66 Wagman, Yorke, Ford (b0145) 2003; 55 Dawson, Ten Haken (b0065) 2005; 15 Cheng, Chuang, Cheng (b0095) 2000; 47 Dawson, McGinn, Normolle (b0125) 2000; 18 Seong, Shim, Lee, Han, Chon, Ahn (b0100) 2007; 67 Stuart, Anand, Jenkins (b0010) 1996; 77 Kubo, Len, Minohara, Mostafavi (b0135) 2000; 27 Dawson, Eccles, Craig (b0030) 2006; 45 Wu, Liu, Chen (b0090) 2004; 10 Dawson, Normolle, Balter, McGinn, Lawrence, Ten Haken (b0060) 2002; 53 Guo, Yu (b0080) 2003; 50 Llovet, Real, Montana (b0015) 2002; 359 Mendez Romero, Wunderink, Hussain (b0025) 2006; 45 Zeng, Tang, Fan (b0085) 2004; 10 Robertson, Lawrence, Dworzanin (b0120) 1993; 11 Suramo, Paivansalo, Myllyla (b0110) 1984; 25 Llovet, Ricci, Mazzaferro (b0155) 2008; 359 Li, Yu, Wang (b0105) 2003; 26 Mendez Romero (10.1016/j.radonc.2011.05.022_b0025) 2006; 45 Llovet (10.1016/j.radonc.2011.05.022_b0015) 2002; 359 Shirato (10.1016/j.radonc.2011.05.022_b0130) 2000; 48 Stuart (10.1016/j.radonc.2011.05.022_b0010) 1996; 77 Balter (10.1016/j.radonc.2011.05.022_b0055) 2002; 52 Kelsey (10.1016/j.radonc.2011.05.022_b0050) 2005; 28 Mornex (10.1016/j.radonc.2011.05.022_b0115) 2006; 66 Poon (10.1016/j.radonc.2011.05.022_b0005) 2001; 234 Wagman (10.1016/j.radonc.2011.05.022_b0145) 2003; 55 Lo (10.1016/j.radonc.2011.05.022_b0020) 2002; 35 Cheng (10.1016/j.radonc.2011.05.022_b0095) 2000; 47 de Pooter (10.1016/j.radonc.2011.05.022_b0150) 2008; 88 Dawson (10.1016/j.radonc.2011.05.022_b0065) 2005; 15 Dawson (10.1016/j.radonc.2011.05.022_b0125) 2000; 18 Molinelli (10.1016/j.radonc.2011.05.022_b0140) 2008; 87 Kubo (10.1016/j.radonc.2011.05.022_b0135) 2000; 27 Dawson (10.1016/j.radonc.2011.05.022_b0030) 2006; 45 Beddar (10.1016/j.radonc.2011.05.022_b0045) 2007; 67 Guo (10.1016/j.radonc.2011.05.022_b0080) 2003; 50 Imada (10.1016/j.radonc.2011.05.022_b0040) 2010; 96 Robertson (10.1016/j.radonc.2011.05.022_b0120) 1993; 11 Ben-Josef (10.1016/j.radonc.2011.05.022_b0070) 2005; 23 Suramo (10.1016/j.radonc.2011.05.022_b0110) 1984; 25 Wu (10.1016/j.radonc.2011.05.022_b0090) 2004; 10 Seong (10.1016/j.radonc.2011.05.022_b0075) 2003; 55 Dawson (10.1016/j.radonc.2011.05.022_b0060) 2002; 53 Liang (10.1016/j.radonc.2011.05.022_b0035) 2011; 98 Li (10.1016/j.radonc.2011.05.022_b0105) 2003; 26 Zeng (10.1016/j.radonc.2011.05.022_b0085) 2004; 10 Seong (10.1016/j.radonc.2011.05.022_b0100) 2007; 67 Llovet (10.1016/j.radonc.2011.05.022_b0155) 2008; 359 |
| References_xml | – volume: 53 start-page: 810 year: 2002 end-page: 821 ident: b0060 article-title: Analysis of radiation-induced liver disease using the Lyman NTCP model publication-title: Int J Radiat Oncol Biol Phys – volume: 11 start-page: 1286 year: 1993 end-page: 1293 ident: b0120 article-title: Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy publication-title: J Clin Oncol – volume: 10 start-page: 307 year: 2004 end-page: 316 ident: b0085 article-title: A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma publication-title: Cancer J – volume: 77 start-page: 2217 year: 1996 end-page: 2222 ident: b0010 article-title: Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival publication-title: Cancer – volume: 67 start-page: 630 year: 2007 end-page: 638 ident: b0045 article-title: Correlation between internal fiducial tumor motion and external marker motion for liver tumors imaged with 4D-CT publication-title: Int J Radiat Oncol Biol Phys – volume: 52 start-page: 266 year: 2002 end-page: 271 ident: b0055 article-title: Daily targeting of intrahepatic tumors for radiotherapy publication-title: Int J Radiat Oncol Biol Phys – volume: 47 start-page: 435 year: 2000 end-page: 442 ident: b0095 article-title: Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys – volume: 55 start-page: 329 year: 2003 end-page: 336 ident: b0075 article-title: Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: a retrospective study of 158 patients publication-title: Int J Radiat Oncol Biol Phys – volume: 87 start-page: 432 year: 2008 end-page: 438 ident: b0140 article-title: Simultaneous tumour dose escalation and liver sparing in Stereotactic Body Radiation Therapy (SBRT) for liver tumours due to CTV-to-PTV margin reduction publication-title: Radiother Oncol – volume: 50 start-page: 500 year: 2003 end-page: 503 ident: b0080 article-title: The long-term efficacy of combined chemoembolization and local irradiation in the treatment of patients with large hepatocellular carcinoma publication-title: Hepatogastroenterology – volume: 45 start-page: 831 year: 2006 end-page: 837 ident: b0025 article-title: Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase i–ii study publication-title: Acta Oncol – volume: 10 start-page: 2184 year: 2004 end-page: 2189 ident: b0090 article-title: Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma publication-title: World J Gastroenterol – volume: 67 start-page: 1037 year: 2007 end-page: 1042 ident: b0100 article-title: Evaluation of the prognostic value of Okuda, Cancer of the Liver Italian Program, and Japan Integrated Staging systems for hepatocellular carcinoma patients undergoing radiotherapy publication-title: Int J Radiat Oncol Biol Phys – volume: 35 start-page: 1164 year: 2002 end-page: 1171 ident: b0020 article-title: Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma publication-title: Hepatology – volume: 359 start-page: 378 year: 2008 end-page: 390 ident: b0155 article-title: Sorafenib in advanced hepatocellular carcinoma publication-title: N Engl J Med – volume: 48 start-page: 435 year: 2000 end-page: 442 ident: b0130 article-title: Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor publication-title: Int J Radiat Oncol Biol Phys – volume: 55 start-page: 659 year: 2003 end-page: 668 ident: b0145 article-title: Respiratory gating for liver tumors: use in dose escalation publication-title: Int J Radiat Oncol Biol Phys – volume: 234 start-page: 63 year: 2001 end-page: 70 ident: b0005 article-title: Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years publication-title: Ann Surg – volume: 98 start-page: 265 year: 2011 end-page: 269 ident: b0035 article-title: Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis publication-title: Radiother Oncol – volume: 96 start-page: 236 year: 2010 end-page: 242 ident: b0040 article-title: Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy – relation to prognosis and liver function publication-title: Radiother Oncol – volume: 66 start-page: 1152 year: 2006 end-page: 1158 ident: b0115 article-title: Feasibility and efficacy of high-dose three-dimensional-conformal radiotherapy in cirrhotic patients with small-size hepatocellular carcinoma non-eligible for curative therapies–mature results of the French Phase II RTF-1 trial publication-title: Int J Radiat Oncol Biol Phys – volume: 88 start-page: 376 year: 2008 end-page: 381 ident: b0150 article-title: Automated non-coplanar beam direction optimization improves IMRT in SBRT of liver metastasis publication-title: Radiother Oncol – volume: 359 start-page: 1734 year: 2002 end-page: 1739 ident: b0015 article-title: Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial publication-title: Lancet – volume: 15 start-page: 279 year: 2005 end-page: 283 ident: b0065 article-title: Partial volume tolerance of the liver to radiation publication-title: Semin Radiat Oncol – volume: 28 start-page: 576 year: 2005 end-page: 580 ident: b0050 article-title: Retrospective clinicopathologic correlation of gross tumor size of hepatocellular carcinoma: implications for stereotactic body radiotherapy publication-title: Am J Clin Oncol – volume: 25 start-page: 129 year: 1984 end-page: 131 ident: b0110 article-title: Cranio-caudal movements of the liver, pancreas and kidneys in respiration publication-title: Acta Radiol Diagn (Stockh) – volume: 27 start-page: 346 year: 2000 end-page: 353 ident: b0135 article-title: Breathing-synchronized radiotherapy program at the University of California Davis Cancer Center publication-title: Med Phys – volume: 23 start-page: 8739 year: 2005 end-page: 8747 ident: b0070 article-title: Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies publication-title: J Clin Oncol – volume: 18 start-page: 2210 year: 2000 end-page: 2218 ident: b0125 article-title: Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies publication-title: J Clin Oncol – volume: 45 start-page: 856 year: 2006 end-page: 864 ident: b0030 article-title: Individualized image guided iso-NTCP based liver cancer SBRT publication-title: Acta Oncol – volume: 26 start-page: e92 year: 2003 end-page: 99 ident: b0105 article-title: Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage III hepatocellular carcinoma publication-title: Am J Clin Oncol – volume: 35 start-page: 1164 year: 2002 ident: 10.1016/j.radonc.2011.05.022_b0020 article-title: Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma publication-title: Hepatology doi: 10.1053/jhep.2002.33156 – volume: 47 start-page: 435 year: 2000 ident: 10.1016/j.radonc.2011.05.022_b0095 article-title: Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(00)00462-4 – volume: 88 start-page: 376 year: 2008 ident: 10.1016/j.radonc.2011.05.022_b0150 article-title: Automated non-coplanar beam direction optimization improves IMRT in SBRT of liver metastasis publication-title: Radiother Oncol doi: 10.1016/j.radonc.2008.06.001 – volume: 45 start-page: 831 year: 2006 ident: 10.1016/j.radonc.2011.05.022_b0025 article-title: Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase i–ii study publication-title: Acta Oncol doi: 10.1080/02841860600897934 – volume: 77 start-page: 2217 year: 1996 ident: 10.1016/j.radonc.2011.05.022_b0010 article-title: Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival publication-title: Cancer doi: 10.1002/(SICI)1097-0142(19960601)77:11<2217::AID-CNCR6>3.0.CO;2-M – volume: 50 start-page: 500 year: 2003 ident: 10.1016/j.radonc.2011.05.022_b0080 article-title: The long-term efficacy of combined chemoembolization and local irradiation in the treatment of patients with large hepatocellular carcinoma publication-title: Hepatogastroenterology – volume: 18 start-page: 2210 year: 2000 ident: 10.1016/j.radonc.2011.05.022_b0125 article-title: Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies publication-title: J Clin Oncol doi: 10.1200/JCO.2000.18.11.2210 – volume: 23 start-page: 8739 year: 2005 ident: 10.1016/j.radonc.2011.05.022_b0070 article-title: Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies publication-title: J Clin Oncol doi: 10.1200/JCO.2005.01.5354 – volume: 87 start-page: 432 year: 2008 ident: 10.1016/j.radonc.2011.05.022_b0140 article-title: Simultaneous tumour dose escalation and liver sparing in Stereotactic Body Radiation Therapy (SBRT) for liver tumours due to CTV-to-PTV margin reduction publication-title: Radiother Oncol doi: 10.1016/j.radonc.2007.11.015 – volume: 67 start-page: 1037 year: 2007 ident: 10.1016/j.radonc.2011.05.022_b0100 article-title: Evaluation of the prognostic value of Okuda, Cancer of the Liver Italian Program, and Japan Integrated Staging systems for hepatocellular carcinoma patients undergoing radiotherapy publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2006.10.035 – volume: 27 start-page: 346 year: 2000 ident: 10.1016/j.radonc.2011.05.022_b0135 article-title: Breathing-synchronized radiotherapy program at the University of California Davis Cancer Center publication-title: Med Phys doi: 10.1118/1.598837 – volume: 15 start-page: 279 year: 2005 ident: 10.1016/j.radonc.2011.05.022_b0065 article-title: Partial volume tolerance of the liver to radiation publication-title: Semin Radiat Oncol doi: 10.1016/j.semradonc.2005.04.005 – volume: 52 start-page: 266 year: 2002 ident: 10.1016/j.radonc.2011.05.022_b0055 article-title: Daily targeting of intrahepatic tumors for radiotherapy publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)01815-6 – volume: 55 start-page: 659 year: 2003 ident: 10.1016/j.radonc.2011.05.022_b0145 article-title: Respiratory gating for liver tumors: use in dose escalation publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)03941-X – volume: 66 start-page: 1152 year: 2006 ident: 10.1016/j.radonc.2011.05.022_b0115 article-title: Feasibility and efficacy of high-dose three-dimensional-conformal radiotherapy in cirrhotic patients with small-size hepatocellular carcinoma non-eligible for curative therapies–mature results of the French Phase II RTF-1 trial publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2006.06.015 – volume: 11 start-page: 1286 year: 1993 ident: 10.1016/j.radonc.2011.05.022_b0120 article-title: Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy publication-title: J Clin Oncol doi: 10.1200/JCO.1993.11.7.1286 – volume: 25 start-page: 129 year: 1984 ident: 10.1016/j.radonc.2011.05.022_b0110 article-title: Cranio-caudal movements of the liver, pancreas and kidneys in respiration publication-title: Acta Radiol Diagn (Stockh) doi: 10.1177/028418518402500208 – volume: 55 start-page: 329 year: 2003 ident: 10.1016/j.radonc.2011.05.022_b0075 article-title: Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: a retrospective study of 158 patients publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)03929-9 – volume: 45 start-page: 856 year: 2006 ident: 10.1016/j.radonc.2011.05.022_b0030 article-title: Individualized image guided iso-NTCP based liver cancer SBRT publication-title: Acta Oncol doi: 10.1080/02841860600936369 – volume: 96 start-page: 236 year: 2010 ident: 10.1016/j.radonc.2011.05.022_b0040 article-title: Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy – relation to prognosis and liver function publication-title: Radiother Oncol doi: 10.1016/j.radonc.2010.03.025 – volume: 98 start-page: 265 year: 2011 ident: 10.1016/j.radonc.2011.05.022_b0035 article-title: Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis publication-title: Radiother Oncol doi: 10.1016/j.radonc.2010.10.014 – volume: 10 start-page: 2184 year: 2004 ident: 10.1016/j.radonc.2011.05.022_b0090 article-title: Therapeutic effects and prognostic factors in three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for hepatocellular carcinoma publication-title: World J Gastroenterol doi: 10.3748/wjg.v10.i15.2184 – volume: 359 start-page: 378 year: 2008 ident: 10.1016/j.radonc.2011.05.022_b0155 article-title: Sorafenib in advanced hepatocellular carcinoma publication-title: N Engl J Med doi: 10.1056/NEJMoa0708857 – volume: 53 start-page: 810 year: 2002 ident: 10.1016/j.radonc.2011.05.022_b0060 article-title: Analysis of radiation-induced liver disease using the Lyman NTCP model publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)02846-8 – volume: 28 start-page: 576 year: 2005 ident: 10.1016/j.radonc.2011.05.022_b0050 article-title: Retrospective clinicopathologic correlation of gross tumor size of hepatocellular carcinoma: implications for stereotactic body radiotherapy publication-title: Am J Clin Oncol doi: 10.1097/01.coc.0000184657.65679.6f – volume: 48 start-page: 435 year: 2000 ident: 10.1016/j.radonc.2011.05.022_b0130 article-title: Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(00)00625-8 – volume: 359 start-page: 1734 year: 2002 ident: 10.1016/j.radonc.2011.05.022_b0015 article-title: Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(02)08649-X – volume: 10 start-page: 307 year: 2004 ident: 10.1016/j.radonc.2011.05.022_b0085 article-title: A comparison of chemoembolization combination with and without radiotherapy for unresectable hepatocellular carcinoma publication-title: Cancer J doi: 10.1097/00130404-200409000-00008 – volume: 67 start-page: 630 year: 2007 ident: 10.1016/j.radonc.2011.05.022_b0045 article-title: Correlation between internal fiducial tumor motion and external marker motion for liver tumors imaged with 4D-CT publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2006.10.007 – volume: 234 start-page: 63 year: 2001 ident: 10.1016/j.radonc.2011.05.022_b0005 article-title: Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years publication-title: Ann Surg doi: 10.1097/00000658-200107000-00010 – volume: 26 start-page: e92 year: 2003 ident: 10.1016/j.radonc.2011.05.022_b0105 article-title: Study of local three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for patients with stage III hepatocellular carcinoma publication-title: Am J Clin Oncol doi: 10.1097/01.COC.0000077936.97997.AB |
| SSID | ssj0002037 |
| Score | 2.1742435 |
| Snippet | To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver cancer patients... Abstract Purpose To implement a reliable, practical and reproducible treatment procedure, based on in-room kV-image guidance and respiratory control, for liver... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 56 |
| SubjectTerms | Aged Aged, 80 and over Biomarkers, Tumor - analysis Carcinoma Carcinoma, Hepatocellular - radiotherapy Female Follow-Up Studies Hematology, Oncology and Palliative Medicine Hepatocellular Humans Image-guided radiotherapy Liver cancer Liver neoplasm Liver Neoplasms - radiotherapy Male Middle Aged Patient Positioning Quality of Life Radiotherapy Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Conformal - methods Remission Induction Respiration Respiratory control Survival Rate Treatment Outcome |
| Title | Treatment of primary liver cancer using highly-conformal radiotherapy with kv-image guidance and respiratory control |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0167814011002155 https://www.clinicalkey.es/playcontent/1-s2.0-S0167814011002155 https://dx.doi.org/10.1016/j.radonc.2011.05.022 https://www.ncbi.nlm.nih.gov/pubmed/21640423 https://www.proquest.com/docview/912796745 |
| Volume | 102 |
| WOSCitedRecordID | wos000300654700010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: ScienceDirect database customDbUrl: eissn: 1879-0887 dateEnd: 20130228 omitProxy: false ssIdentifier: ssj0002037 issn: 0167-8140 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1La9wwEBabpJReSt9NH0GH3hYbWys_dAwhJSlpKM2Wbk_CtuRlE-Mt-yL5Vf2LnZFkr5NtSFroxbsYS7I1n0cz45lPhHxgGpyALBiAk1MojxeKe8hC7qlBGiC_OX6bMZtNJKen6WgkvvR6v5pamFWV1HV6eSl-_ldRwzkQNpbO_oW4207hBPwHocMRxA7H-wm-TR3HZGZHJlFh-gVmeBXwszTxASQqrq488IeN3Vr1Z5mauHqsKxufvVh50Hys--PlRLW1BbPO13mX6d41cb92u8Hrp3VxLXZ_klnSR5X1T_wffhuONkrnezbxhlO3nK4ThVx2f__AP2obYGGE6Wg5xi3JwFoe-md-N4xh8kG6YYy2vuYYa3jg3tZJTSbsCeocubmu6e2AbQDUauEo7qznlut9Y6WwQYtzH-YWpsFxuUZ-YKukb3Bwn-EN4PhIsAdGUrRFdlgSCVCjO_vHh6NP7eLPAkvT2txwU61pUgo3x7rNGrrN2zFWz_AJeezcFbpvYfaU9HT9jDz87BIynpNFizY6LalDGzVooxZt1KCN3kQb7aKNItpogzbaoI2ChGgHbdSh7QX59vFweHDkuY08vILHYgFHHisGiqBMS3DmglLnTLA80IIXZR6nTEV5nodxKXKhkgScBs1EESoeaZ1mKR-8JNv1tNavkWIgzZQOQyW44kmsRSbCItAcrHDwzDO1SwbNhMrCsdzjZiuVbNIZz6UVg0QxyCCSIIZd4rWt3FTdcX3UyEo2Fcyw5koA1x3tkj-103OnP-YylHMmA7kBuG5LZxtbm_ceY9IGTBKWDvwemNV6upxLEbJExAmHzl9ZkLUPz8KYY8bcm3980Lfk0folf0e2F7Olfk8eFKvFZD7bI1vJKN1zr85vv-f3WA |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Treatment+of+primary+liver+cancer+using+highly-conformal+radiotherapy+with+kv-image+guidance+and+respiratory+control&rft.jtitle=Radiotherapy+and+oncology&rft.au=Law%2C+Ada+L.Y.&rft.au=Ng%2C+Wai-Tong&rft.au=Lee%2C+Michael+C.H.&rft.au=Chan%2C+Augustine+T.S.&rft.date=2012-01-01&rft.pub=Elsevier+Ireland+Ltd&rft.issn=0167-8140&rft.volume=102&rft.issue=1&rft.spage=56&rft.epage=61&rft_id=info:doi/10.1016%2Fj.radonc.2011.05.022&rft.externalDocID=S0167814011002155 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01678140%2FS0167814011X00166%2Fcov150h.gif |