Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis

Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We aimed to more completely incorporate HLA alleles, their interactions, and recently discovered non-HLA loci into an improved T1D GRS...

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Vydáno v:	Diabetes care Ročník 42; číslo 2; s. 200
Hlavní autoři:	Sharp, Seth A, Rich, Stephen S, Wood, Andrew R, Jones, Samuel E, Beaumont, Robin N, Harrison, James W, Schneider, Darius A, Locke, Jonathan M, Tyrrell, Jess, Weedon, Michael N, Hagopian, William A, Oram, Richard A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.02.2019
Témata:	Alleles Case-Control Studies Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Female Genetic Predisposition to Disease Genetic Testing - methods Genetic Testing - standards Haplotypes HLA Antigens - genetics Humans Incidence Infant, Newborn Male Neonatal Screening - methods Neonatal Screening - standards Polymorphism, Single Nucleotide Quality Improvement Reference Standards Research Design - standards Risk Factors United Kingdom United Kingdom
ISSN:	1935-5548, 1935-5548
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