Early tumor shrinkage as a predictor of favorable outcomes in patients with advanced pancreatic cancer treated with FOLFIRINOX

There are several reports on the correlation between early tumor shrinkage (ETS) or depth of response (DpR) and survival in chemotherapies for colorectal cancer; however, few studies have investigated it in pancreatic cancer. We therefore investigated whether the ETS will predict outcomes in 59 pati...

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Vydáno v:Oncotarget Ročník 7; číslo 41; s. 67314 - 67320
Hlavní autoři: Kaga, Yasuhiro, Sunakawa, Yu, Kubota, Yutaro, Tagawa, Teppei, Yamamoto, Taikan, Ikusue, Toshikazu, Uto, Yu, Miyashita, Kouichirou, Toshima, Hirokazu, Kobayashi, Kouji, Hisamatsu, Atsushi, Ichikawa, Wataru, Sekikawa, Takashi, Shimada, Ken, Sasaki, Yasutsuna
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 11.10.2016
Témata:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Prognosis
Treatment Outcome
FOLFIRINOX
pancreatic cancer
early tumor shrinkage
ISSN:1949-2553
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Abstract There are several reports on the correlation between early tumor shrinkage (ETS) or depth of response (DpR) and survival in chemotherapies for colorectal cancer; however, few studies have investigated it in pancreatic cancer. We therefore investigated whether the ETS will predict outcomes in 59 patients with advanced pancreatic cancer treated with FOLFIRINOX therapy. The association of ETS with progression-free survival (PFS) and overall survival (OS) was evaluated but also we addressed to the correlation between outcomes and DpR. ETS was defined as a reduction ≥ 20% of target lesions' diameters measured at 6 to 8 weeks from treatment start. DpR was percentage of maximal tumor shrinkage observed at the nadir diameter compared with baseline. Among 47 evaluable patients for the ETS, 12 (25.5%) patients experienced ETS. The ETS was significantly associated with better PFS (9.0 vs. 4.2 months) as well as OS (24.0 vs. 9.1 months); moreover, the association had a statistically significance for PFS but a strong trend for OS in multivariate analysis. The DpR was statistically significantly but weakly associated with OS. In conclusion, this is the first report that the early response to chemotherapy may predict favorable outcomes in patients with advanced pancreatic cancer treated with FOLFIRINOX therapy.
AbstractList There are several reports on the correlation between early tumor shrinkage (ETS) or depth of response (DpR) and survival in chemotherapies for colorectal cancer; however, few studies have investigated it in pancreatic cancer. We therefore investigated whether the ETS will predict outcomes in 59 patients with advanced pancreatic cancer treated with FOLFIRINOX therapy. The association of ETS with progression-free survival (PFS) and overall survival (OS) was evaluated but also we addressed to the correlation between outcomes and DpR. ETS was defined as a reduction ≥ 20% of target lesions' diameters measured at 6 to 8 weeks from treatment start. DpR was percentage of maximal tumor shrinkage observed at the nadir diameter compared with baseline. Among 47 evaluable patients for the ETS, 12 (25.5%) patients experienced ETS. The ETS was significantly associated with better PFS (9.0 vs. 4.2 months) as well as OS (24.0 vs. 9.1 months); moreover, the association had a statistically significance for PFS but a strong trend for OS in multivariate analysis. The DpR was statistically significantly but weakly associated with OS. In conclusion, this is the first report that the early response to chemotherapy may predict favorable outcomes in patients with advanced pancreatic cancer treated with FOLFIRINOX therapy.
Author Kobayashi, Kouji
Yamamoto, Taikan
Hisamatsu, Atsushi
Kubota, Yutaro
Sekikawa, Takashi
Toshima, Hirokazu
Ichikawa, Wataru
Sasaki, Yasutsuna
Tagawa, Teppei
Sunakawa, Yu
Uto, Yu
Miyashita, Kouichirou
Ikusue, Toshikazu
Shimada, Ken
Kaga, Yasuhiro
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  givenname: Yasuhiro
  surname: Kaga
  fullname: Kaga, Yasuhiro
  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
– sequence: 2
  givenname: Yu
  surname: Sunakawa
  fullname: Sunakawa, Yu
  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
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  givenname: Yutaro
  surname: Kubota
  fullname: Kubota, Yutaro
  organization: Division of Medical Oncology, Showa University School of Medicine, Tokyo, Japan
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  givenname: Teppei
  surname: Tagawa
  fullname: Tagawa, Teppei
  organization: Division of Medical Oncology, Showa University School of Medicine, Tokyo, Japan
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  surname: Yamamoto
  fullname: Yamamoto, Taikan
  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
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  givenname: Toshikazu
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  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
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  fullname: Uto, Yu
  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
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  givenname: Kouichirou
  surname: Miyashita
  fullname: Miyashita, Kouichirou
  organization: Divison of Medical Oncology, Showa University Northern Yokohama Hospital, Yokohama, Japan
– sequence: 9
  givenname: Hirokazu
  surname: Toshima
  fullname: Toshima, Hirokazu
  organization: Divison of Medical Oncology, Showa University Koto Toyosu Hospital, Tokyo, Japan
– sequence: 10
  givenname: Kouji
  surname: Kobayashi
  fullname: Kobayashi, Kouji
  organization: Divison of Medical Oncology, Showa University Koto Toyosu Hospital, Tokyo, Japan
– sequence: 11
  givenname: Atsushi
  surname: Hisamatsu
  fullname: Hisamatsu, Atsushi
  organization: Divison of Medical Oncology, Showa University Koto Toyosu Hospital, Tokyo, Japan
– sequence: 12
  givenname: Wataru
  surname: Ichikawa
  fullname: Ichikawa, Wataru
  organization: Division of Medical Oncology, Showa University Fujigaoka Hospital, Yokohama, Japan
– sequence: 13
  givenname: Takashi
  surname: Sekikawa
  fullname: Sekikawa, Takashi
  organization: Division of Medical Oncology, Showa University Fujigaoka Hospital, Yokohama, Japan
– sequence: 14
  givenname: Ken
  surname: Shimada
  fullname: Shimada, Ken
  organization: Divison of Medical Oncology, Showa University Koto Toyosu Hospital, Tokyo, Japan
– sequence: 15
  givenname: Yasutsuna
  surname: Sasaki
  fullname: Sasaki, Yasutsuna
  organization: Division of Medical Oncology, Showa University School of Medicine, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27634903$$D View this record in MEDLINE/PubMed
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SubjectTerms Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Prognosis
Treatment Outcome
Title Early tumor shrinkage as a predictor of favorable outcomes in patients with advanced pancreatic cancer treated with FOLFIRINOX
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