Pediatric multiple sclerosis

Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS. Clinical, MRI and laboratory data suggest differences in the immune response and CNS environment between adults and children with MS. Yeh et al...

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Veröffentlicht in:Nature reviews. Neurology Jg. 5; H. 11; S. 621 - 631
Hauptverfasser: Yeh, E. Ann, Chitnis, Tanuja, Krupp, Lauren, Ness, Jayne, Chabas, Dorothée, Kuntz, Nancy, Waubant, Emmanuelle
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.11.2009
Nature Publishing Group
Schlagworte:
Accreditation
Adolescent
Adult
Adults
Age
Age Factors
Care and treatment
Child
Children
Demographic aspects
Demographics
Diagnosis
Diagnosis, Differential
Disease Progression
Disease Susceptibility
Diseases
Encephalomyelitis
Environment
Female
Genetic aspects
Herpesvirus 4, Human - physiology
Humans
Magnetic Resonance Imaging - methods
Male
Medical education
Medicine
Medicine & Public Health
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - etiology
Multiple Sclerosis - therapy
Neurology
North America - epidemiology
Pathogenesis
Pediatrics
Randomized Controlled Trials as Topic
review-article
Sex Factors
North America
United States
United States > US
ISSN:1759-4758, 1759-4766, 1759-4766
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Abstract Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS. Clinical, MRI and laboratory data suggest differences in the immune response and CNS environment between adults and children with MS. Yeh et al . provide a comprehensive overview of the pediatric MS field, including epidemiology, disease mechanisms, diagnosis and treatment. Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field. Key Points Pediatric multiple sclerosis (MS) represents ∼3–4% of all cases of MS In North America, greater diversity in ethnicity, race and ancestry is observed among individuals with pediatric MS than among adults with MS, possibly reflecting changing demographic trends Studies have suggested environmental influences on pediatric MS susceptibility, including Epstein–Barr virus and exposure to cigarette smoke Acute disseminating encephalomyelitis must be differentiated from MS and is seen more commonly in children than in adults New MRI criteria will, hopefully, help to discriminate pediatric MS from acute disseminated encephalomyelitis Currently available first-line therapies for adults with MS seem to be safe and well tolerated in pediatric MS
AbstractList Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field.
Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field. doi: 10.1038/nrneurol.2009.158
Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field.Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field.
Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS. Clinical, MRI and laboratory data suggest differences in the immune response and CNS environment between adults and children with MS. Yeh et al . provide a comprehensive overview of the pediatric MS field, including epidemiology, disease mechanisms, diagnosis and treatment. Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment, pathogenesis, demographics, and natural history of this disorder. Genetic and environmental factors seem to exert critical influences on its development. Clinical, MRI and laboratory data from prepubertal and postpubertal children suggest differences between the immune response and/or CNS environment in younger compared with older children and adults with MS. Randomized, controlled treatment trials for pediatric MS have not yet been performed, but therapies used in adult MS have been evaluated in this population, and their use seems to be safe. This article provides a comprehensive review of current knowledge regarding pediatric MS, highlighting new advances in the field. Key Points Pediatric multiple sclerosis (MS) represents ∼3–4% of all cases of MS In North America, greater diversity in ethnicity, race and ancestry is observed among individuals with pediatric MS than among adults with MS, possibly reflecting changing demographic trends Studies have suggested environmental influences on pediatric MS susceptibility, including Epstein–Barr virus and exposure to cigarette smoke Acute disseminating encephalomyelitis must be differentiated from MS and is seen more commonly in children than in adults New MRI criteria will, hopefully, help to discriminate pediatric MS from acute disseminated encephalomyelitis Currently available first-line therapies for adults with MS seem to be safe and well tolerated in pediatric MS
Audience Academic
Author Yeh, E. Ann
Krupp, Lauren
Waubant, Emmanuelle
Kuntz, Nancy
Chitnis, Tanuja
Ness, Jayne
Chabas, Dorothée
Author_xml – sequence: 1
  givenname: E. Ann
  surname: Yeh
  fullname: Yeh, E. Ann
  email: ayeh@thejni.org
  organization: Pediatric Multiple Sclerosis Center of the Jacobs Neurological Institute, University at Buffalo, The State University of New York
– sequence: 2
  givenname: Tanuja
  surname: Chitnis
  fullname: Chitnis, Tanuja
  organization: Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, Harvard Medical School
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  givenname: Lauren
  surname: Krupp
  fullname: Krupp, Lauren
  organization: National Pediatric Multiple Sclerosis Center, Stony Brook University Medical Center
– sequence: 4
  givenname: Jayne
  surname: Ness
  fullname: Ness, Jayne
  organization: Center for Pediatric Onset Demyelinating Disease, Children's Hospital of Alabama and University of Alabama at Birmingham
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  givenname: Dorothée
  surname: Chabas
  fullname: Chabas, Dorothée
  organization: UCSF Regional Pediatric Multiple Sclerosis Center, University of California
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  fullname: Kuntz, Nancy
  organization: Mayo Clinic Pediatric Multiple Sclerosis Center
– sequence: 7
  givenname: Emmanuelle
  surname: Waubant
  fullname: Waubant, Emmanuelle
  organization: UCSF Regional Pediatric Multiple Sclerosis Center, University of California
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  day: 01
PublicationDecade 2000
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature reviews. Neurology
PublicationTitleAbbrev Nat Rev Neurol
PublicationTitleAlternate Nat Rev Neurol
PublicationYear 2009
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
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Snippet Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS....
Pediatric multiple sclerosis (MS) accounts for up to 5% of all MS cases. Work conducted over the past 5 years has provided new information about the treatment,...
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SubjectTerms Accreditation
Adolescent
Adult
Adults
Age
Age Factors
Care and treatment
Child
Children
Demographic aspects
Demographics
Diagnosis
Diagnosis, Differential
Disease Progression
Disease Susceptibility
Diseases
Encephalomyelitis
Environment
Female
Genetic aspects
Herpesvirus 4, Human - physiology
Humans
Magnetic Resonance Imaging - methods
Male
Medical education
Medicine
Medicine & Public Health
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - etiology
Multiple Sclerosis - therapy
Neurology
North America - epidemiology
Pathogenesis
Pediatrics
Randomized Controlled Trials as Topic
review-article
Sex Factors
Title Pediatric multiple sclerosis
URI https://link.springer.com/article/10.1038/nrneurol.2009.158
https://www.ncbi.nlm.nih.gov/pubmed/19826402
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