A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by methyltransferases that use the universal methyl donor S-adenosyl-l-methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolat...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 99; číslo 8; s. 5606
Hlavní autori:	Friso, Simonetta, Choi, Sang-Woon, Girelli, Domenico, Mason, Joel B, Dolnikowski, Gregory G, Bagley, Pamela J, Olivieri, Oliviero, Jacques, Paul F, Rosenberg, Irwin H, Corrocher, Roberto, Selhub, Jacob
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.04.2002
Predmet:	Adult Aged Coronary Artery Disease - genetics DNA Methylation Female Folic Acid - blood Genotype Homozygote Humans Male Mass Spectrometry Methylenetetrahydrofolate Dehydrogenase (NAD+) Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Models, Statistical Mutation Oxidoreductases - genetics Oxidoreductases Acting on CH-NH Group Donors - genetics Polymorphism, Genetic
ISSN:	0027-8424
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