A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by methyltransferases that use the universal methyl donor S-adenosyl-l-methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolat...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 99; no. 8; p. 5606
Main Authors:	Friso, Simonetta, Choi, Sang-Woon, Girelli, Domenico, Mason, Joel B, Dolnikowski, Gregory G, Bagley, Pamela J, Olivieri, Oliviero, Jacques, Paul F, Rosenberg, Irwin H, Corrocher, Roberto, Selhub, Jacob
Format:	Journal Article
Language:	English
Published:	United States 16.04.2002
Subjects:	Adult Aged Coronary Artery Disease - genetics DNA Methylation Female Folic Acid - blood Genotype Homozygote Humans Male Mass Spectrometry Methylenetetrahydrofolate Dehydrogenase (NAD+) Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Models, Statistical Mutation Oxidoreductases - genetics Oxidoreductases Acting on CH-NH Group Donors - genetics Polymorphism, Genetic
ISSN:	0027-8424
Online Access:	Get more information
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