Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

The complement system is part of the innate immune response responsible for removing pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via microglia-mediated pruning of inappropriate synapses during brain development. However, less is known about the role of co...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 35; no. 38; p. 13029
Main Authors:	Shi, Qiaoqiao, Colodner, Kenneth J, Matousek, Sarah B, Merry, Katherine, Hong, Soyon, Kenison, Jessica E, Frost, Jeffrey L, Le, Kevin X, Li, Shaomin, Dodart, Jean-Cosme, Caldarone, Barbara J, Stevens, Beth, Lemere, Cynthia A
Format:	Journal Article
Language:	English
Published:	United States 23.09.2015
Subjects:	Adaptation, Physiological - genetics Age Factors Aging - pathology Animals Complement C3 - deficiency Complement C3 - genetics Conditioning (Psychology) - physiology Excitatory Postsynaptic Potentials - physiology Exploratory Behavior - physiology Fear Hippocampus - metabolism Hippocampus - pathology Hippocampus - ultrastructure Male Maze Learning Mice Mice, Inbred C57BL Mice, Knockout Neuronal Plasticity - genetics Neuronal Plasticity - physiology Phosphopyruvate Hydratase - metabolism Synapses - pathology Synapses - ultrastructure Synapsins - metabolism Synaptophysin - metabolism Synaptosomes - metabolism aging synapse CA3 cognition innate immunity complement C3
ISSN:	1529-2401, 1529-2401
Online Access:	Get more information
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