Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver model was engineered to incorporate hepatic sinusoidal flow, transport, and lipotoxic stress risk factors (glucose, insulin, free fatty acids) w...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	JCI insight Ročník 1; číslo 20; s. e90954
Hlavní autori:	Feaver, Ryan E., Cole, Banumathi K., Lawson, Mark J., Hoang, Stephen A., Marukian, Svetlana, Blackman, Brett R., Figler, Robert A., Sanyal, Arun J., Wamhoff, Brian R., Dash, Ajit
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Society for Clinical Investigation 08.12.2016
Predmet:	Animals Coculture Techniques Glucose - metabolism Hepatic Stellate Cells - cytology Hepatocytes - cytology Humans Inflammation Insulin Resistance Lipids - analysis Liver Macrophages - cytology Metabolome Mice, Inbred C57BL Models, Biological Non-alcoholic Fatty Liver Disease - physiopathology Technical Advance Transcriptome
ISSN:	2379-3708, 2379-3708
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!