Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

A barrier to drug development for nonalcoholic steatohepatitis (NASH) is the absence of translational preclinical human-relevant systems. An in vitro liver model was engineered to incorporate hepatic sinusoidal flow, transport, and lipotoxic stress risk factors (glucose, insulin, free fatty acids) w...

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Bibliographic Details
Published in:	JCI insight Vol. 1; no. 20; p. e90954
Main Authors:	Feaver, Ryan E., Cole, Banumathi K., Lawson, Mark J., Hoang, Stephen A., Marukian, Svetlana, Blackman, Brett R., Figler, Robert A., Sanyal, Arun J., Wamhoff, Brian R., Dash, Ajit
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 08.12.2016
Subjects:	Animals Coculture Techniques Glucose - metabolism Hepatic Stellate Cells - cytology Hepatocytes - cytology Humans Inflammation Insulin Resistance Lipids - analysis Liver Macrophages - cytology Metabolome Mice, Inbred C57BL Models, Biological Non-alcoholic Fatty Liver Disease - physiopathology Technical Advance Transcriptome
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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