Enhancing glioma treatment with 3D scaffolds laden with upconversion nanoparticles and temozolomide in orthotopic mouse model
Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease th...
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| Published in: | Frontiers in chemistry Vol. 12; p. 1445664 |
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21.10.2024
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| Abstract | Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient’s organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model
in vivo
, it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology. |
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| AbstractList | Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient’s organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model in vivo, it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology. Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient's organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model in vivo, it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology.Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient's organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model in vivo, it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology. Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient's organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model , it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology. Targeted drug delivery for primary brain tumors, particularly gliomas, is currently a promising approach to reduce patient relapse rates. The use of substitutable scaffolds, which enable the sustained release of clinically relevant doses of anticancer medications, offers the potential to decrease the toxic burden on the patient’s organism while also enhancing their quality of life and overall survival. Upconversion nanoparticles (UCNPs) are being actively explored as promising agents for detection and monitoring of tumor growth, and as therapeutic agents that can provide isolated therapeutic effects and enhance standard chemotherapy. Our study is focused on the feasibility of constructing scaffolds using methacrylated hyaluronic acid with additional impregnation of UCNPs and the chemotherapeutic drug temozolomide (TMZ) for glioma treatment. The designed scaffolds have been demonstrated their efficacy as a drug and UCNPs delivery system for gliomas. Using the aggressive orthotopic glioma model in vivo , it was found that the scaffolds possess the capacity to ameliorate neurological disorders in mice. Moreover, upon intracranial co-implantation of the scaffolds and glioma cells, the constructs disintegrate into distinct segments, augmenting the release of UCNPs into the surrounding tissue and concurrently reducing postoperative damage to brain tissue. The use of TMZ in the scaffold composition contributed to restraining glioma development and the reduction of tumor invasiveness. Our findings unveil promising prospects for the application of photopolymerizable biocompatible scaffolds in the realm of neuro-oncology. |
| Author | Mishchenko, Tatiana A. Klimenko, Maria O. Savelyev, Alexander G. Zvyagin, Andrei V. Vedunova, Maria V. Guryev, Evgenii L. Gudkov, Sergey V. Khaydukov, Evgeny V. Krysko, Dmitri V. |
| AuthorAffiliation | 6 Petrovsky National Research Center of Surgery , Moscow , Russia 2 Laboratory of Laser Biomedicine , NRC “Kurchatov Institute” , Moscow , Russia 9 Institute of Molecular Theranostics , Sechenov First Moscow State Medical University , Moscow , Russia 4 Cell Death Investigation and Therapy Laboratory , Anatomy and Embryology Unit , Department of Human Structure and Repair , Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium 10 Scientific Center for Translational Medicine , Sirius University of Science and Technology , Sirius , Russia 5 Prokhorov General Physics Institute of the Russian Academy of Sciences , Moscow , Russia 8 Molecular Immunology Department , Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia 1 Institute of Biology and Biomedicine , Lobachevsky State University of Nizhny Novgorod , Nizhny Novgorod , Russia 7 Department of Biomaterials and Bionanotechnology , Laboratory "Polymers for biology" , Shemyakin-Ovchinnikov Institute o |
| AuthorAffiliation_xml | – name: 5 Prokhorov General Physics Institute of the Russian Academy of Sciences , Moscow , Russia – name: 2 Laboratory of Laser Biomedicine , NRC “Kurchatov Institute” , Moscow , Russia – name: 8 Molecular Immunology Department , Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia – name: 6 Petrovsky National Research Center of Surgery , Moscow , Russia – name: 9 Institute of Molecular Theranostics , Sechenov First Moscow State Medical University , Moscow , Russia – name: 10 Scientific Center for Translational Medicine , Sirius University of Science and Technology , Sirius , Russia – name: 4 Cell Death Investigation and Therapy Laboratory , Anatomy and Embryology Unit , Department of Human Structure and Repair , Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium – name: 7 Department of Biomaterials and Bionanotechnology , Laboratory "Polymers for biology" , Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS , Moscow , Russia – name: 1 Institute of Biology and Biomedicine , Lobachevsky State University of Nizhny Novgorod , Nizhny Novgorod , Russia – name: 3 D. I. Mendeleev Russian University of Chemical Technology , Moscow , Russia |
| Author_xml | – sequence: 1 givenname: Tatiana A. surname: Mishchenko fullname: Mishchenko, Tatiana A. – sequence: 2 givenname: Maria O. surname: Klimenko fullname: Klimenko, Maria O. – sequence: 3 givenname: Evgenii L. surname: Guryev fullname: Guryev, Evgenii L. – sequence: 4 givenname: Alexander G. surname: Savelyev fullname: Savelyev, Alexander G. – sequence: 5 givenname: Dmitri V. surname: Krysko fullname: Krysko, Dmitri V. – sequence: 6 givenname: Sergey V. surname: Gudkov fullname: Gudkov, Sergey V. – sequence: 7 givenname: Evgeny V. surname: Khaydukov fullname: Khaydukov, Evgeny V. – sequence: 8 givenname: Andrei V. surname: Zvyagin fullname: Zvyagin, Andrei V. – sequence: 9 givenname: Maria V. surname: Vedunova fullname: Vedunova, Maria V. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39498377$$D View this record in MEDLINE/PubMed |
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| Keywords | temozolomide orthotopic glioma model hyaluronic acid hydrogels upconversion nanoparticles GL261 cells |
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| License | Copyright © 2024 Mishchenko, Klimenko, Guryev, Savelyev, Krysko, Gudkov, Khaydukov, Zvyagin and Vedunova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Rozhina Elvira, Kazan Federal University, Russia Vad Pérez, Mexican Social Security Institute, Mexico Edited by: Kelong Fan, Chinese Academy of Sciences (CAS), China Mars Sharapov, Institute of Cell Biophysics (RAS), Russia These authors have contributed equally to this work and share last authorship |
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