Deconstructing the Phage–Bacterial Biofilm Interaction as a Basis to Establish New Antibiofilm Strategies

The bacterial biofilm constitutes a complex environment that endows the bacterial community within with an ability to cope with biotic and abiotic stresses. Considering the interaction with bacterial viruses, these biofilms contain intrinsic defense mechanisms that protect against phage predation; t...

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Vydáno v:Viruses Ročník 14; číslo 5; s. 1057
Hlavní autoři: Visnapuu, Annegrete, Van der Gucht, Marie, Wagemans, Jeroen, Lavigne, Rob
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 16.05.2022
MDPI
Témata:
Adsorption
antibiofilm mechanism
Bacteria
Bacteria - genetics
Bacterial infections
bacterial–bacteriophage co-evolution
Bacteriophages - genetics
biofilm
biofilm matrix protection mechanisms
Biofilms
Cell interactions
Exopolysaccharides
Extracellular matrix
Gene expression
Gene transfer
Horizontal transfer
Infections
Metabolism
Motility
Peptidoglycans
phage
Phages
Physiology
Predation
Predators
predator–prey arms race
Proteins
Review
Transplants & implants
bacterial–bacteriophage co-evolution
phage–host interaction
biofilm
biofilm matrix protection mechanisms
predator–prey arms race
antibiofilm mechanism
phage
ISSN:1999-4915, 1999-4915
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Shrnutí:The bacterial biofilm constitutes a complex environment that endows the bacterial community within with an ability to cope with biotic and abiotic stresses. Considering the interaction with bacterial viruses, these biofilms contain intrinsic defense mechanisms that protect against phage predation; these mechanisms are driven by physical, structural, and metabolic properties or governed by environment-induced mutations and bacterial diversity. In this regard, horizontal gene transfer can also be a driver of biofilm diversity and some (pro)phages can function as temporary allies in biofilm development. Conversely, as bacterial predators, phages have developed counter mechanisms to overcome the biofilm barrier. We highlight how these natural systems have previously inspired new antibiofilm design strategies, e.g., by utilizing exopolysaccharide degrading enzymes and peptidoglycan hydrolases. Next, we propose new potential approaches including phage-encoded DNases to target extracellular DNA, as well as phage-mediated inhibitors of cellular communication; these examples illustrate the relevance and importance of research aiming to elucidate novel antibiofilm mechanisms contained within the vast set of unknown ORFs from phages.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v14051057