Evidence of repeated zoonotic pathogen spillover events at ecological boundaries
Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drasticall...
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| Vydané v: | Frontiers in public health Ročník 12; s. 1435233 |
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05.11.2024
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| Abstract | Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drastically understudied. Here, we test for the influence of two types of ecosystem boundaries on spillover risk: (1) biotic transition zones such as species range edges and transitions between ecoregions and (2) land use transition zones where wild landscapes occur in close proximity to heavily impacted areas of high human population density. Using ebolavirus as a model system and an ensemble machine learning modeling framework, we investigated the role of likely reservoir (bats) and accidental host (primates) range edges and patterns of land use (defined using SEDAC categories) on past spillover events. Our results show that overlapping species range edges and heightened habitat diversity increase ebolavirus outbreaks risk. Moreover, we show that gradual transition zones, represent by high proportion of rangelands, acts as a buffer to reduces outbreak risks. With increasing landscape changes worldwide, we provide novel ecological and evolutionary insights into our understanding of zoonotic pathogen emergence and highlight the risk of aggressively developing ecological boundaries. |
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| AbstractList | Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drastically understudied. Here, we test for the influence of two types of ecosystem boundaries on spillover risk: (1) biotic transition zones such as species range edges and transitions between ecoregions and (2) land use transition zones where wild landscapes occur in close proximity to heavily impacted areas of high human population density. Using ebolavirus as a model system and an ensemble machine learning modeling framework, we investigated the role of likely reservoir (bats) and accidental host (primates) range edges and patterns of land use (defined using SEDAC categories) on past spillover events. Our results show that overlapping species range edges and heightened habitat diversity increase ebolavirus outbreaks risk. Moreover, we show that gradual transition zones, represent by high proportion of rangelands, acts as a buffer to reduces outbreak risks. With increasing landscape changes worldwide, we provide novel ecological and evolutionary insights into our understanding of zoonotic pathogen emergence and highlight the risk of aggressively developing ecological boundaries. Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drastically understudied. Here, we test for the influence of two types of ecosystem boundaries on spillover risk: (1) biotic transition zones such as species range edges and transitions between ecoregions and (2) land use transition zones where wild landscapes occur in close proximity to heavily impacted areas of high human population density. Using ebolavirus as a model system and an ensemble machine learning modeling framework, we investigated the role of likely reservoir (bats) and accidental host (primates) range edges and patterns of land use (defined using SEDAC categories) on past spillover events. Our results show that overlapping species range edges and heightened habitat diversity increase ebolavirus outbreaks risk. Moreover, we show that gradual transition zones, represent by high proportion of rangelands, acts as a buffer to reduces outbreak risks. With increasing landscape changes worldwide, we provide novel ecological and evolutionary insights into our understanding of zoonotic pathogen emergence and highlight the risk of aggressively developing ecological boundaries.Anthropogenic modifications to the landscape have altered several ecological processes worldwide, creating new ecological boundaries at the human/wildlife interface. Outbreaks of zoonotic pathogens often occur at these ecological boundaries, but the mechanisms behind new emergences remain drastically understudied. Here, we test for the influence of two types of ecosystem boundaries on spillover risk: (1) biotic transition zones such as species range edges and transitions between ecoregions and (2) land use transition zones where wild landscapes occur in close proximity to heavily impacted areas of high human population density. Using ebolavirus as a model system and an ensemble machine learning modeling framework, we investigated the role of likely reservoir (bats) and accidental host (primates) range edges and patterns of land use (defined using SEDAC categories) on past spillover events. Our results show that overlapping species range edges and heightened habitat diversity increase ebolavirus outbreaks risk. Moreover, we show that gradual transition zones, represent by high proportion of rangelands, acts as a buffer to reduces outbreak risks. With increasing landscape changes worldwide, we provide novel ecological and evolutionary insights into our understanding of zoonotic pathogen emergence and highlight the risk of aggressively developing ecological boundaries. |
| Author | Sundaram, Mekala Schmidt, John Paul Drake, John M. Stephens, Patrick R. Filion, Antoine |
| AuthorAffiliation | 2 Department of Infectious Diseases, University of Georgia , Athens, GA , United States 4 Odum School of Ecology and Center for the Ecology of Infectious Diseases, University of Georgia , Athens, GA , United States 1 Department of Integrative Biology, Oklahoma State University , Stillwater, OK , United States 3 Savannah River Ecology Laboratory, University of Georgia , Aiken, SC , United States |
| AuthorAffiliation_xml | – name: 2 Department of Infectious Diseases, University of Georgia , Athens, GA , United States – name: 3 Savannah River Ecology Laboratory, University of Georgia , Aiken, SC , United States – name: 4 Odum School of Ecology and Center for the Ecology of Infectious Diseases, University of Georgia , Athens, GA , United States – name: 1 Department of Integrative Biology, Oklahoma State University , Stillwater, OK , United States |
| Author_xml | – sequence: 1 givenname: Antoine surname: Filion fullname: Filion, Antoine – sequence: 2 givenname: Mekala surname: Sundaram fullname: Sundaram, Mekala – sequence: 3 givenname: John Paul surname: Schmidt fullname: Schmidt, John Paul – sequence: 4 givenname: John M. surname: Drake fullname: Drake, John M. – sequence: 5 givenname: Patrick R. surname: Stephens fullname: Stephens, Patrick R. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39568607$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_zoonoticdis5030018 crossref_primary_10_1177_11795735251322456 crossref_primary_10_1098_rsos_250209 crossref_primary_10_1017_dmp_2025_56 |
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| Keywords | spillover ecological boundaries disease ecology disease emergence filovirus Schmalhausen’s law |
| Language | English |
| License | Copyright © 2024 Filion, Sundaram, Schmidt, Drake and Stephens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| SubjectTerms | Animals Chiroptera - virology disease ecology disease emergence Disease Outbreaks Disease Reservoirs Ebolavirus ecological boundaries Ecosystem filovirus Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - transmission Humans Machine Learning Primates Public Health Schmalhausen’s law spillover Zoonoses - transmission |
| Title | Evidence of repeated zoonotic pathogen spillover events at ecological boundaries |
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