Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes

Telomere length is abnormally short in the CD8(+) T-cell compartment of human immunodeficiency virus type 1 (HIV-1)-infected persons, likely because of chronic cell turnover. Although clonal exhaustion of CD8(+) cytotoxic T lymphocytes (CTL) has been proposed as a mechanism for loss of antigen-speci...

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Bibliographic Details

Published in:	Journal of virology Vol. 77; no. 5; p. 3077
Main Authors:	Dagarag, Mirabelle, Ng, Hwee, Lubong, Rachel, Effros, Rita B, Yang, Otto O
Format:	Journal Article
Language:	English
Published:	United States 01.03.2003
Subjects:	Cytokines - metabolism Cytotoxicity, Immunologic DNA-Binding Proteins HIV-1 - immunology HIV-1 - pathogenicity Humans Lymphocyte Activation T-Lymphocytes, Cytotoxic - enzymology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology Telomerase - genetics Telomerase - metabolism Telomere Transduction, Genetic
ISSN:	0022-538X
Online Access:	Get more information
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