A novel super-resolution microscopy platform for cutaneous alpha-synuclein detection in Parkinson’s disease

Alpha-synuclein (aSyn) aggregates in the central nervous system are the main pathological hallmark of Parkinson’s disease (PD). ASyn aggregates have also been detected in many peripheral tissues, including the skin, thus providing a novel and accessible target tissue for the detection of PD patholog...

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Veröffentlicht in:	Frontiers in molecular neuroscience Jg. 17; S. 1431549
Hauptverfasser:	Sade, Ofir, Fischel, Daphna, Barak-Broner, Noa, Halevi, Shir, Gottfried, Irit, Bar-On, Dana, Sachs, Stefan, Mirelman, Anat, Thaler, Avner, Gour, Aviv, Kestenbaum, Meir, Gana Weisz, Mali, Anis, Saar, Soto, Claudio, Roitman, Melanie Shanie, Shahar, Shimon, Doppler, Kathrin, Sauer, Markus, Giladi, Nir, Lev, Nirit, Alcalay, Roy N., Hassin-Baer, Sharon, Ashery, Uri
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 04.09.2024
Schlagworte:	alpha-synuclein aggregates biomarker density-based spatial clustering of applications with noise (DBSCAN) direct stochastic optical reconstruction microscopy (dSTORM) early diagnosis fast optimized cluster algorithm for localizations (FOCAL) Molecular Neuroscience early diagnosis alpha-synuclein aggregates density-based spatial clustering of applications with noise (DBSCAN) direct stochastic optical reconstruction microscopy (dSTORM) biomarker Parkinson’s disease super-resolution microscopy fast optimized cluster algorithm for localizations (FOCAL)
ISSN:	1662-5099, 1662-5099
Online-Zugang:	Volltext
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