Dysregulated monocyte-derived macrophage response to Group B Streptococcus in newborns

(Group B , GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termi...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1268804
Main Authors:	Ravi, Denho, Ntinopoulou, Erato, Guetta, Nessim, Weier, Manuela, Vogel, Verena, Spellerberg, Barbara, Sendi, Parham, Gremlich, Sandrine, Roger, Thierry, Giannoni, Eric
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 14.11.2023
Subjects:	Adult cytokine group B streptococcus Humans Immunology Infant, Newborn innate immunity Interleukin-10 Interleukin-12 Interleukin-23 Interleukin-6 macrophage Macrophage Colony-Stimulating Factor Macrophages Neonatal Sepsis newborn phagocytosis Streptococcus agalactiae cytokine group B streptococcus phagocytosis streptococcus agalactiae innate immunity macrophage newborn
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	(Group B , GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses. The goal of this study was to compare the response of newborn and adult monocyte-derived macrophages (MDMs) to GBS. Monocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis. GBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs. Altogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction.
AbstractList	(Group B , GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses. The goal of this study was to compare the response of newborn and adult monocyte-derived macrophages (MDMs) to GBS. Monocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis. GBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs. Altogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction. Streptococcus agalactiae (Group B Streptococcus, GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses. The goal of this study was to compare the response of newborn and adult monocyte-derived macrophages (MDMs) to GBS.IntroductionStreptococcus agalactiae (Group B Streptococcus, GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses. The goal of this study was to compare the response of newborn and adult monocyte-derived macrophages (MDMs) to GBS.Monocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis.MethodsMonocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis.GBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs.ResultsGBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs.Altogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction.DiscussionAltogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction. IntroductionStreptococcus agalactiae (Group B Streptococcus, GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses. The goal of this study was to compare the response of newborn and adult monocyte-derived macrophages (MDMs) to GBS.MethodsMonocytes from umbilical cord blood of healthy term newborns and from peripheral blood of healthy adult subjects were cultured with M-CSF to induce MDMs. M-CSF-MDMs, GM-CSF- and IFNγ-activated MDMs were exposed to GBS COH1, a reference strain for neonatal sepsis. ResultsGBS induced a greater release of IL-1β, IL-6, IL-10, IL-12p70 and IL-23 in newborn compared to adult MDMs, while IL-18, IL-21, IL-22, TNF, RANTES/CCL5, MCP-1/CCL2 and IL-8/CXCL8 were released at similar levels. MDM responses to GBS were strongly influenced by conditions of activation and were distinct from those to synthetic bacterial lipopeptides and lipopolysaccharides. Under similar conditions of opsonization, newborn MDMs phagocytosed and killed GBS as efficiently as adult MDMs. DiscussionAltogether, the production of excessive levels of Th1- (IL-12p70), Th17-related (IL-1β, IL-6, IL-23) and anti-inflammatory (IL-10) cytokines is consistent with a dysregulated response to GBS in newborns. The high responsiveness of newborn MDMs may play a role in the progression of GBS infection in newborns, possibly contributing to the development of life-threatening organ dysfunction.
Author	Guetta, Nessim Weier, Manuela Ravi, Denho Roger, Thierry Vogel, Verena Ntinopoulou, Erato Spellerberg, Barbara Sendi, Parham Giannoni, Eric Gremlich, Sandrine
AuthorAffiliation	1 Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland 4 Institute for Infectious Diseases, University of Bern , Bern , Switzerland 2 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland 3 Institute of Medical Microbiology and Hygiene, University of Ulm , Ulm , Germany
AuthorAffiliation_xml	– name: 2 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland – name: 1 Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland – name: 3 Institute of Medical Microbiology and Hygiene, University of Ulm , Ulm , Germany – name: 4 Institute for Infectious Diseases, University of Bern , Bern , Switzerland
Author_xml	– sequence: 1 givenname: Denho surname: Ravi fullname: Ravi, Denho – sequence: 2 givenname: Erato surname: Ntinopoulou fullname: Ntinopoulou, Erato – sequence: 3 givenname: Nessim surname: Guetta fullname: Guetta, Nessim – sequence: 4 givenname: Manuela surname: Weier fullname: Weier, Manuela – sequence: 5 givenname: Verena surname: Vogel fullname: Vogel, Verena – sequence: 6 givenname: Barbara surname: Spellerberg fullname: Spellerberg, Barbara – sequence: 7 givenname: Parham surname: Sendi fullname: Sendi, Parham – sequence: 8 givenname: Sandrine surname: Gremlich fullname: Gremlich, Sandrine – sequence: 9 givenname: Thierry surname: Roger fullname: Roger, Thierry – sequence: 10 givenname: Eric surname: Giannoni fullname: Giannoni, Eric
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38035076$$D View this record in MEDLINE/PubMed
BookMark	eNp9Uk1v1DAUtFARLaV_gAPKkUsWf8WxTwgKlEqVOPBxtWznZesqsYPttNp_T9JdqpYDvtjv-c3Mk2ZeoqMQAyD0muANY1K96_04zhuKKdsQKqTE_Bk6IULwmlHKjx69j9FZzjd4OVwxxpoX6JhJzBrcihP069MuJ9jOgynQVWMM0e0K1B0kf7s2jEtxujZbqBLkKYYMVYnVRYrzVH2svpcEU4kuOjfnyocqwJ2NKeRX6Hlvhgxnh_sU_fzy-cf51_rq28Xl-Yer2nGhSk17TFUD1khFLZEdc4oqi5UkvcWux70QDTbUctUJLpuOW8M5lq1hvGEWGDtFl3veLpobPSU_mrTT0Xh934hpq00q3g2gLbHOtsQ2He256Z11S0FAYmiBKiEWrvd7rmm2I3QOQklmeEL69Cf4a72Nt5pgIWmL123eHhhS_D1DLnr02cEwmABxzppKJSRuOFvF3jwWe1D568wyQPcDiwF5sah_GCFYrwnQ9wnQawL0IQELSP4Dcr6Y4uO6sB_-B_0Dw5G47g
CitedBy_id	crossref_primary_10_1093_jleuko_qiaf071 crossref_primary_10_1002_ccr3_70768 crossref_primary_10_3389_fgene_2024_1357704 crossref_primary_10_1128_cmr_00154_22 crossref_primary_10_1093_femsre_fuae009 crossref_primary_10_1016_j_intimp_2024_112969
Cites_doi	10.1128/IAI.00647-20 10.1002/eji.201243077 10.1046/j.1365-2567.1998.00518.x 10.1002/cyto.b.20474 10.1128/iai.49.3.550-556.1985 10.1016/S0140-6736(19)32989-7 10.3389/fimmu.2017.01037 10.1038/s41577-023-00848-y 10.1542/peds.2011-3453 10.1016/S0140-6736(16)31593-8 10.1016/j.jpeds.2018.05.048 10.1016/S2214-109X(22)00093-6 10.1086/315796 10.1016/j.immuni.2016.02.026 10.1128/IAI.00535-10 10.3389/fimmu.2021.655027 10.1093/infdis/165.2.306 10.1084/jem.144.6.1484 10.1620/tjem.253.269 10.1016/j.micinf.2008.06.001 10.1128/IAI.68.4.2167-2170.2000 10.4049/jimmunol.0901481 10.1073/pnas.1515793113 10.1038/ni.3745 10.4014/jmb.2103.03053 10.1038/nri.2017.54 10.1073/pnas.0506758102 10.1128/iai.64.7.2467-2473.1996 10.1016/j.cellimm.2013.01.010 10.1203/00006450-198910000-00021 10.1371/journal.pone.0033419 10.1046/j.1365-2567.1998.00402.x 10.1073/pnas.1514018113 10.1016/j.chom.2008.11.002 10.1136/fn.72.3.F172 10.1016/j.isci.2020.101207 10.1074/jbc.C114.548982 10.1084/jem.20031272 10.1038/embor.2010.189 10.1016/j.chom.2016.06.003 10.1186/s12950-017-0151-x 10.4049/jimmunol.1102543 10.3389/fimmu.2018.01597 10.1016/j.clim.2009.07.003 10.4049/jimmunol.169.7.3970 10.1128/iai.64.8.2941-2944.1996 10.1016/j.immuni.2017.03.009 10.1182/blood-2006-06-027862 10.1016/j.cyto.2007.07.004 10.1038/ni.1610 10.1203/00006450-200203000-00007 10.1111/j.1651-2227.2004.tb02933.x 10.1016/j.immuni.2021.10.012 10.3389/fimmu.2019.02461 10.1002/eji.201444707 10.1111/dmcn.15643 10.1016/j.immuni.2014.06.008 10.1128/CMR.00019-17 10.1128/IAI.71.11.6344-6353.2003 10.1016/S0140-6736(22)02185-7 10.1080/21505594.2016.1252016 10.1128/IAI.00076-11 10.3349/ymj.2016.57.2.283 10.1126/scitranslmed.aax4517 10.3389/fimmu.2017.01497 10.3389/fimmu.2017.01243 10.1371/journal.pone.0029963
ContentType	Journal Article
Copyright	Copyright © 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni. Copyright © 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni
Copyright_xml	– notice: Copyright © 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni. – notice: Copyright © 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA
DOI	10.3389/fimmu.2023.1268804
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1664-3224
ExternalDocumentID	oai_doaj_org_article_b1bcb71b5d2f4afcbc71b1e80e7e2966 PMC10682703 38035076 10_3389_fimmu_2023_1268804
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM ACXDI CGR CUY CVF ECM EIF IPNFZ NPM RIG 7X8 5PM
ID	FETCH-LOGICAL-c469t-2f0295eba892b18d3c929b0981fb0cf0f6650a2b49d6485d4ba44087a3453be33
IEDL.DBID	DOA
ISICitedReferencesCount	6
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001114818600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1664-3224
IngestDate	Fri Oct 03 12:52:46 EDT 2025 Thu Aug 21 18:36:19 EDT 2025 Thu Sep 04 19:40:26 EDT 2025 Thu Apr 03 06:55:49 EDT 2025 Sat Nov 29 05:40:39 EST 2025 Tue Nov 18 22:43:48 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	cytokine group B streptococcus phagocytosis streptococcus agalactiae innate immunity macrophage newborn
Language	English
License	Copyright © 2023 Ravi, Ntinopoulou, Guetta, Weier, Vogel, Spellerberg, Sendi, Gremlich, Roger and Giannoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c469t-2f0295eba892b18d3c929b0981fb0cf0f6650a2b49d6485d4ba44087a3453be33
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ORCID: Barbara Spellerberg, orcid.org/0000-0001-7552-8764; Parham Sendi, orcid.org/0000-0002-7347-6312; Thierry Roger, orcid.org/0000-0002-9358-0109; Eric Giannoni, orcid.org/0000-0003-0897-6529 Edited by: Joseph Alex Duncan, University of North Carolina at Chapel Hill, United States Reviewed by: Wendy W. J. Unger, Erasmus Medical Center, Netherlands; Asmaa Tazi, INSERM U1016 Institut Cochin, France; Pascal M. Lavoie, University of British Columbia, Canada
OpenAccessLink	https://doaj.org/article/b1bcb71b5d2f4afcbc71b1e80e7e2966
PMID	38035076
PQID	2896805436
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_b1bcb71b5d2f4afcbc71b1e80e7e2966 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10682703 proquest_miscellaneous_2896805436 pubmed_primary_38035076 crossref_primary_10_3389_fimmu_2023_1268804 crossref_citationtrail_10_3389_fimmu_2023_1268804
PublicationCentury	2000
PublicationDate	2023-11-14
PublicationDateYYYYMMDD	2023-11-14
PublicationDate_xml	– month: 11 year: 2023 text: 2023-11-14 day: 14
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	Frontiers in immunology
PublicationTitleAlternate	Front Immunol
PublicationYear	2023
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Manel (B38) 2008; 9 Jaguin (B31) 2013; 281 Valentin-Weigand (B60) 1996; 64 Roger (B29) 2016; 113 Gupta (B46) 2014; 289 Anthony (B55) 1989; 26 Marodi (B53) 2000; 68 Coligan (B34) 1993 Pavlou (B58) 2017; 14 Andersen (B21) 2004; 93 Schneider (B30) 2018; 9 Zhang (B52) 2013; 43 Michl (B57) 1976; 144 Flaherty (B64) 2021; 89 Pryzwansky (B37) 1985; 49 Ulas (B13) 2017; 18 Bakker (B51) 1998; 94 Cornacchione (B62) 1998; 93 Charrel-Dennis (B41) 2008; 4 van der Poll (B23) 2021; 54 Chishiki (B70) 2021; 253 Martin (B26) 1992; 165 (B5) 2022; 400 Costa (B45) 2012; 188 Sharma (B11) 2015; 45 Brook (B69) 2020; 12 Liu (B2) 2016; 388 Deshmukh (B43) 2011; 12 Tettelin (B32) 2005; 102 Goncalves (B4) 2022; 10 Bender (B22) 2008; 55 Mohamed (B18) 2007; 39 Giannoni (B28) 2011; 79 Gille (B19) 2009; 76 Gordon (B36) 2016; 44 Aksoy (B12) 2007; 109 Berner (B50) 2002; 51 Drossou (B71) 1995; 72 Levy (B17) 2003; 71 Razzaghian (B67) 2021; 12 Mass (B24) 2023; 23 Andrade (B42) 2016; 20 Kaneko (B33) 2016; 57 Korir (B61) 2017; 8 Rudd (B1) 2020; 395 Goriely (B39) 2004; 199 Giannoni (B3) 2018; 201 Ehrnstrom (B44) 2017; 8 La Pine (B48) 2003; 54 Ciarlo (B59) 2017; 8 Kollmann (B9) 2017; 46 Belderbos (B14) 2009; 133 Libster (B7) 2012; 130 Currie (B49) 2011; 79 Mynarek (B6) 2023 Korir (B8) 2017; 30 Murray (B25) 2014; 41 Cusumano (B65) 1996; 64 Henneke (B54) 2002; 169 Lund (B27) 2020; 23 Wynn (B68) 2016; 113 Belderbos (B15) 2012; 7 Kollmann (B16) 2009; 183 Van Bambeke (B35) 2006; 9 Oliveira (B63) 2012; 7 Chen (B66) 2021; 31 Zhang (B10) 2017; 17 Joyner (B47) 2000; 182 Talati (B40) 2008; 10 Ramond (B56) 2019; 10 Kolter (B20) 2017; 8
References_xml	– volume: 89 year: 2021 ident: B64 article-title: Distinct group B streptococcus sequence and capsule types differentially impact macrophage stress and inflammatory signaling responses publication-title: Infect Immun doi: 10.1128/IAI.00647-20 – volume: 43 year: 2013 ident: B52 article-title: Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection publication-title: Eur J Immunol doi: 10.1002/eji.201243077 – volume: 94 year: 1998 ident: B51 article-title: Functional immaturity of rat alveolar macrophages during postnatal development publication-title: Immunology doi: 10.1046/j.1365-2567.1998.00518.x – volume: 76 year: 2009 ident: B19 article-title: Phagocytosis and postphagocytic reaction of cord blood and adult blood monocyte after infection with green fluorescent protein-labeled Escherichia coli and group B Streptococci publication-title: Cytometry B Clin Cytom doi: 10.1002/cyto.b.20474 – volume: 49 year: 1985 ident: B37 article-title: Opsonized streptococcal cell walls cross-link human leukocytes and erythrocytes by complement receptors publication-title: Infect Immun doi: 10.1128/iai.49.3.550-556.1985 – volume: 395 year: 2020 ident: B1 article-title: Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study publication-title: Lancet doi: 10.1016/S0140-6736(19)32989-7 – volume: 8 year: 2017 ident: B59 article-title: Sirtuin 2 deficiency increases bacterial phagocytosis by macrophages and protects from chronic staphylococcal infection publication-title: Front Immunol doi: 10.3389/fimmu.2017.01037 – volume: 23 start-page: 563 year: 2023 ident: B24 article-title: Tissue-specific macrophages: how they develop and choreograph tissue biology publication-title: Nat Rev Immunol doi: 10.1038/s41577-023-00848-y – volume: 130 start-page: e8 year: 2012 ident: B7 article-title: Long-term outcomes of group B streptococcal meningitis publication-title: Pediatrics doi: 10.1542/peds.2011-3453 – volume: 388 year: 2016 ident: B2 article-title: Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals publication-title: Lancet doi: 10.1016/S0140-6736(16)31593-8 – volume: 201 start-page: 106 year: 2018 ident: B3 article-title: Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: A prospective population-based cohort study publication-title: J Pediatr doi: 10.1016/j.jpeds.2018.05.048 – volume: 10 year: 2022 ident: B4 article-title: Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(22)00093-6 – volume: 54 year: 2003 ident: B48 article-title: Defective production of IL-18 and IL-12 by cord blood mononuclear cells influences the T helper-1 interferon gamma response to group B Streptococci publication-title: Pediatr Res doi: 10.1086/315796 – volume: 44 year: 2016 ident: B36 article-title: Phagocytosis: an immunobiologic process publication-title: Immunity doi: 10.1016/j.immuni.2016.02.026 – volume: 79 year: 2011 ident: B49 article-title: Preterm infants have deficient monocyte and lymphocyte cytokine responses to group B streptococcus publication-title: Infect Immun doi: 10.1128/IAI.00535-10 – volume: 12 year: 2021 ident: B67 article-title: Neonatal T helper 17 responses are skewed towards an immunoregulatory interleukin-22 phenotype publication-title: Front Immunol doi: 10.3389/fimmu.2021.655027 – volume: 165 year: 1992 ident: B26 article-title: The effect of type-specific polysaccharide capsule on the clearance of group B streptococci from the lungs of infant and adult rats publication-title: J Infect Dis doi: 10.1093/infdis/165.2.306 – volume: 144 year: 1976 ident: B57 article-title: 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation publication-title: J Exp Med doi: 10.1084/jem.144.6.1484 – volume: 253 year: 2021 ident: B70 article-title: Cytokine profiles before and after exchange transfusions in severe late-onset neonatal group B streptococcus meningitis: A case report publication-title: Tohoku J Exp Med doi: 10.1620/tjem.253.269 – volume: 10 year: 2008 ident: B40 article-title: Role of bacterial DNA in macrophage activation by group B streptococci publication-title: Microbes Infect doi: 10.1016/j.micinf.2008.06.001 – volume: 68 year: 2000 ident: B53 article-title: Survival of group B streptococcus type III in mononuclear phagocytes: differential regulation of bacterial killing in cord macrophages by human recombinant gamma interferon and granulocyte-macrophage colony-stimulating factor publication-title: Infect Immun doi: 10.1128/IAI.68.4.2167-2170.2000 – volume: 183 year: 2009 ident: B16 article-title: Neonatal innate TLR-mediated responses are distinct from those of adults publication-title: J Immunol doi: 10.4049/jimmunol.0901481 – volume: 113 year: 2016 ident: B68 article-title: Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1515793113 – volume: 18 year: 2017 ident: B13 article-title: S100-alarmin-induced innate immune programming protects newborn infants from sepsis publication-title: Nat Immunol doi: 10.1038/ni.3745 – volume: 31 year: 2021 ident: B66 article-title: IL-17A Secreted by Th17 Cells Is Essential for the Host against Streptococcus agalactiae Infections publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.2103.03053 – volume: 17 start-page: 495 year: 2017 ident: B10 article-title: Unique aspects of the perinatal immune system publication-title: Nat Rev Immunol doi: 10.1038/nri.2017.54 – volume: 102 year: 2005 ident: B32 article-title: Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome" publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0506758102 – volume: 64 year: 1996 ident: B60 article-title: Entry and intracellular survival of group B streptococci in J774 macrophages publication-title: Infect Immun doi: 10.1128/iai.64.7.2467-2473.1996 – volume: 281 start-page: 51 year: 2013 ident: B31 article-title: Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin publication-title: Cell Immunol doi: 10.1016/j.cellimm.2013.01.010 – volume: 26 year: 1989 ident: B55 article-title: Opsonic activity of human IgG and IgM antibody for type III group B streptococci publication-title: Pediatr Res doi: 10.1203/00006450-198910000-00021 – volume: 7 year: 2012 ident: B15 article-title: Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors publication-title: PloS One doi: 10.1371/journal.pone.0033419 – volume: 93 start-page: 86 year: 1998 ident: B62 article-title: Group B streptococci persist inside macrophages publication-title: Immunology doi: 10.1046/j.1365-2567.1998.00402.x – volume: 113 start-page: E997 year: 2016 ident: B29 article-title: High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1514018113 – volume: 4 year: 2008 ident: B41 article-title: TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA publication-title: Cell Host Microbe doi: 10.1016/j.chom.2008.11.002 – volume: 72 year: 1995 ident: B71 article-title: Concentrations of main serum opsonins in early infancy publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/fn.72.3.F172 – volume: 23 start-page: 101207 year: 2020 ident: B27 article-title: Developmental immaturity of siglec receptor expression on neonatal alveolar macrophages predisposes to severe group B streptococcal infection publication-title: iScience doi: 10.1016/j.isci.2020.101207 – volume: 289 year: 2014 ident: B46 article-title: RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages publication-title: J Biol Chem doi: 10.1074/jbc.C114.548982 – volume: 199 year: 2004 ident: B39 article-title: A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells publication-title: J Exp Med doi: 10.1084/jem.20031272 – volume: 12 year: 2011 ident: B43 article-title: Macrophages recognize streptococci through bacterial single-stranded RNA publication-title: EMBO Rep doi: 10.1038/embor.2010.189 – volume: 20 start-page: 49 year: 2016 ident: B42 article-title: Group B streptococcus degrades cyclic-di-AMP to modulate STING-dependent type I interferon production publication-title: Cell Host Microbe doi: 10.1016/j.chom.2016.06.003 – volume: 14 start-page: 4 year: 2017 ident: B58 article-title: Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells publication-title: J Inflammation (Lond) doi: 10.1186/s12950-017-0151-x – volume: 188 year: 2012 ident: B45 article-title: Activation of the NLRP3 inflammasome by group B streptococci publication-title: J Immunol doi: 10.4049/jimmunol.1102543 – volume: 9 year: 2018 ident: B30 article-title: IRF5 is a key regulator of macrophage response to lipopolysaccharide in newborns publication-title: Front Immunol doi: 10.3389/fimmu.2018.01597 – volume: 133 year: 2009 ident: B14 article-title: Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life publication-title: Clin Immunol doi: 10.1016/j.clim.2009.07.003 – volume: 169 year: 2002 ident: B54 article-title: Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways publication-title: J Immunol doi: 10.4049/jimmunol.169.7.3970 – volume: 64 year: 1996 ident: B65 article-title: Role of gamma interferon in a neonatal mouse model of group B streptococcal disease publication-title: Infect Immun doi: 10.1128/iai.64.8.2941-2944.1996 – volume: 46 year: 2017 ident: B9 article-title: Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny publication-title: Immunity doi: 10.1016/j.immuni.2017.03.009 – volume: 109 year: 2007 ident: B12 article-title: Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells publication-title: Blood doi: 10.1182/blood-2006-06-027862 – volume: 39 year: 2007 ident: B18 article-title: Levels of pro-inflammatory cytokines produced from cord blood in-vitro are pathogen dependent and increased in comparison to adult controls publication-title: Cytokine doi: 10.1016/j.cyto.2007.07.004 – volume: 9 year: 2008 ident: B38 article-title: The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat publication-title: Nat Immunol doi: 10.1038/ni.1610 – volume: 51 year: 2002 ident: B50 article-title: Cytokine expression of cord and adult blood mononuclear cells in response to Streptococcus agalactiae publication-title: Pediatr Res doi: 10.1203/00006450-200203000-00007 – volume: 93 year: 2004 ident: B21 article-title: Clinical features and epidemiology of septicaemia and meningitis in neonates due to Streptococcus agalactiae in Copenhagen County, Denmark: a 10 year survey from 1992 to 2001 publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.2004.tb02933.x – volume: 54 year: 2021 ident: B23 article-title: The immunology of sepsis publication-title: Immunity doi: 10.1016/j.immuni.2021.10.012 – volume-title: Current Protocols in Immunology year: 1993 ident: B34 – volume: 10 year: 2019 ident: B56 article-title: Pivotal role of mitochondria in macrophage response to bacterial pathogens publication-title: Front Immunol doi: 10.3389/fimmu.2019.02461 – volume: 45 year: 2015 ident: B11 article-title: Impaired NLRP3 inflammasome activity during fetal development regulates IL-1beta production in human monocytes publication-title: Eur J Immunol doi: 10.1002/eji.201444707 – year: 2023 ident: B6 article-title: Mortality and neurodevelopmental outcome after invasive group B streptococcal infection in infants publication-title: Dev Med Child Neurol doi: 10.1111/dmcn.15643 – volume: 182 year: 2000 ident: B47 article-title: Effects of group B streptococci on cord and adult mononuclear cell interleukin-12 and interferon-gamma mRNA accumulation and protein secretion publication-title: J Infect Dis doi: 10.1086/315796 – volume: 41 start-page: 14 year: 2014 ident: B25 article-title: Macrophage activation and polarization: nomenclature and experimental guidelines publication-title: Immunity doi: 10.1016/j.immuni.2014.06.008 – volume: 9 year: 2006 ident: B35 article-title: Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives publication-title: Curr Opin Drug Discov Devel – volume: 30 year: 2017 ident: B8 article-title: Intrinsic maturational neonatal immune deficiencies and susceptibility to group B streptococcus infection publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00019-17 – volume: 71 year: 2003 ident: B17 article-title: Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release publication-title: Infect Immun doi: 10.1128/IAI.71.11.6344-6353.2003 – volume: 400 year: 2022 ident: B5 article-title: Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 publication-title: Lancet doi: 10.1016/S0140-6736(22)02185-7 – volume: 8 year: 2017 ident: B61 article-title: Differing mechanisms of surviving phagosomal stress among group B Streptococcus strains of varying genotypes publication-title: Virulence doi: 10.1080/21505594.2016.1252016 – volume: 79 year: 2011 ident: B28 article-title: Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns publication-title: Infect Immun doi: 10.1128/IAI.00076-11 – volume: 57 year: 2016 ident: B33 article-title: A simple, reproducible, inexpensive, yet old-fashioned method for determining phagocytic and bactericidal activities of macrophages publication-title: Yonsei Med J doi: 10.3349/ymj.2016.57.2.283 – volume: 12 year: 2020 ident: B69 article-title: BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aax4517 – volume: 8 year: 2017 ident: B20 article-title: Codevelopment of microbiota and innate immunity and the risk for group B streptococcal disease publication-title: Front Immunol doi: 10.3389/fimmu.2017.01497 – volume: 55 year: 2008 ident: B22 article-title: Early and late markers for the detection of early-onset neonatal sepsis publication-title: Dan Med Bull – volume: 8 year: 2017 ident: B44 article-title: Toll-like receptor 8 is a major sensor of group B streptococcus but not escherichia coli in human primary monocytes and macrophages publication-title: Front Immunol doi: 10.3389/fimmu.2017.01243 – volume: 7 year: 2012 ident: B63 article-title: Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages publication-title: PloS One doi: 10.1371/journal.pone.0029963
SSID	ssj0000493335
Score	2.3909652
Snippet	(Group B , GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns... Streptococcus agalactiae (Group B Streptococcus, GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to... IntroductionStreptococcus agalactiae (Group B Streptococcus, GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	1268804
SubjectTerms	Adult cytokine group B streptococcus Humans Immunology Infant, Newborn innate immunity Interleukin-10 Interleukin-12 Interleukin-23 Interleukin-6 macrophage Macrophage Colony-Stimulating Factor Macrophages Neonatal Sepsis newborn phagocytosis Streptococcus agalactiae
Title	Dysregulated monocyte-derived macrophage response to Group B Streptococcus in newborns
URI	https://www.ncbi.nlm.nih.gov/pubmed/38035076 https://www.proquest.com/docview/2896805436 https://pubmed.ncbi.nlm.nih.gov/PMC10682703 https://doaj.org/article/b1bcb71b5d2f4afcbc71b1e80e7e2966
Volume	14
WOSCitedRecordID	wos001114818600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYoolIvqNAHWygyUm9VIH7EsY-FgnoBcWirvVl-iq0gQbtZpL30tzOOw2q3qsqll0ixHdn6ZmJ_EzvzIfRJlLaMwovCcRcKboIqjIi8oLVRwhLiFfW92ER9dSXHY3W9IvWVzoTl9MAZuBNLrLM1sZWnkZvorIMbEmQZ6kCBq6fZF1jPSjD1K_NexliV_5KBKEydxMnd3fw4iYUfEyrAa_naStQn7P8by_zzsOTK6nPxGm0PtBF_ycPdQRuh2UUvs5Dk4g36-XUBHfSq8sFj8KzWLbpQeHCvh1RgklDXDUwdeJrPxAbctbj_7oRPcdqZvu9amBrdfIYnDQaqDa7RzN6iHxfn38--FYNiAkAtVFfQWFJVBWukopZIzxywH1sqSaItXQSrACEz1HLlBZeV59YkxenaMF4xGxh7hzabtgl7CEthlBFWEBFgoSulZcLbIB08pCLgPkLkCT3thnTiSdXiVkNYkRDXPeI6Ia4HxEfo8_KZ-5xM45-tT5NRli1TIuy-ANxDD-6hn3OPETp6MqmGFyfthpgmtPOZhkhTSCCsDNq8zyZedsVk2nCtoUauGX9tLOs1zeSmT84NIbakMI1--B-j30evEiLp30fCD9BmN52Hj2jLPXST2fQQvajH8rB3fLhe_j5_BKiGDAM
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dysregulated+monocyte-derived+macrophage+response+to+Group+B+Streptococcus+in+newborns&rft.jtitle=Frontiers+in+immunology&rft.au=Ravi%2C+Denho&rft.au=Ntinopoulou%2C+Erato&rft.au=Guetta%2C+Nessim&rft.au=Weier%2C+Manuela&rft.date=2023-11-14&rft.issn=1664-3224&rft.eissn=1664-3224&rft.volume=14&rft.spage=1268804&rft_id=info:doi/10.3389%2Ffimmu.2023.1268804&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon