Prognosis and risk factors of chronic kidney disease progression in patients with diabetic kidney disease and non-diabetic kidney disease: a prospective cohort CKD-ROUTE study
Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 pre-dialysis CKD patients were recruited. Patients were categorized into two groups according to the etiologies of D...
Uloženo v:
| Vydáno v: | Renal failure Ročník 44; číslo 1; s. 1310 - 1319 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York
Taylor & Francis
31.12.2022
Taylor & Francis Ltd Taylor & Francis Group |
| Témata: | |
| ISSN: | 0886-022X, 1525-6049, 1525-6049 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 pre-dialysis CKD patients were recruited. Patients were categorized into two groups according to the etiologies of DKD and non-diabetic kidney disease (NDKD). Propensity score matching was performed to adjust for confounding factors, resulting in 197 patients being assigned to DKD and NDKD groups, respectively. The primary endpoints were 50% estimated glomerular filtration rate (eGFR) decline and initiation of kidney replacement therapy (KRT). The secondary endpoints were all-cause death and the development of cardiovascular disease (CVD) events. We found that DKD patients have a higher risk to develop 50% eGFR decline endpoint (HR:2.30, 95%CI [1.48-3.58], p < 0.001) and KRT endpoint (HR:1.64, 95%CI [1.13-2.37], p < 0.05) than NDKD patients. The 3-year cumulative incidence of 50% eGFR decline and KRT endpoint was significantly higher in DKD patients (26.90% vs.13.71% and 35.03% vs. 22.34%, respectively). The Cox regression analyses showed that the increased systolic blood pressure (SBP), DKD, decreased serum albumin (Alb), and higher CKD stages were risk factors for the 50% eGFR decline endpoint; the increased SBP, DKD, decreased serum Alb, serum creatinine (Scr), higher CKD stages, presence of proteinuria and CVD were risk factors for KRT endpoint; the increased age, decreased hemoglobin (Hb), decreased serum Alb were risk factors for all-cause death endpoint; the increased age, decreased serum Alb were risk factors for CVD events endpoint. Appropriate preventive or therapeutic interventions should be taken to control these predictive factors to delay the development of CKD complications, thereby improving the prognosis and reducing the disease burden of the high-risk populations. |
|---|---|
| AbstractList | Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 pre-dialysis CKD patients were recruited. Patients were categorized into two groups according to the etiologies of DKD and non-diabetic kidney disease (NDKD). Propensity score matching was performed to adjust for confounding factors, resulting in 197 patients being assigned to DKD and NDKD groups, respectively. The primary endpoints were 50% estimated glomerular filtration rate (eGFR) decline and initiation of kidney replacement therapy (KRT). The secondary endpoints were all-cause death and the development of cardiovascular disease (CVD) events. We found that DKD patients have a higher risk to develop 50% eGFR decline endpoint (HR:2.30, 95%CI [1.48-3.58], p < 0.001) and KRT endpoint (HR:1.64, 95%CI [1.13-2.37], p < 0.05) than NDKD patients. The 3-year cumulative incidence of 50% eGFR decline and KRT endpoint was significantly higher in DKD patients (26.90% vs.13.71% and 35.03% vs. 22.34%, respectively). The Cox regression analyses showed that the increased systolic blood pressure (SBP), DKD, decreased serum albumin (Alb), and higher CKD stages were risk factors for the 50% eGFR decline endpoint; the increased SBP, DKD, decreased serum Alb, serum creatinine (Scr), higher CKD stages, presence of proteinuria and CVD were risk factors for KRT endpoint; the increased age, decreased hemoglobin (Hb), decreased serum Alb were risk factors for all-cause death endpoint; the increased age, decreased serum Alb were risk factors for CVD events endpoint. Appropriate preventive or therapeutic interventions should be taken to control these predictive factors to delay the development of CKD complications, thereby improving the prognosis and reducing the disease burden of the high-risk populations. Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 pre-dialysis CKD patients were recruited. Patients were categorized into two groups according to the etiologies of DKD and non-diabetic kidney disease (NDKD). Propensity score matching was performed to adjust for confounding factors, resulting in 197 patients being assigned to DKD and NDKD groups, respectively. The primary endpoints were 50% estimated glomerular filtration rate (eGFR) decline and initiation of kidney replacement therapy (KRT). The secondary endpoints were all-cause death and the development of cardiovascular disease (CVD) events. We found that DKD patients have a higher risk to develop 50% eGFR decline endpoint (HR:2.30, 95%CI [1.48-3.58], p < 0.001) and KRT endpoint (HR:1.64, 95%CI [1.13-2.37], p < 0.05) than NDKD patients. The 3-year cumulative incidence of 50% eGFR decline and KRT endpoint was significantly higher in DKD patients (26.90% vs.13.71% and 35.03% vs. 22.34%, respectively). The Cox regression analyses showed that the increased systolic blood pressure (SBP), DKD, decreased serum albumin (Alb), and higher CKD stages were risk factors for the 50% eGFR decline endpoint; the increased SBP, DKD, decreased serum Alb, serum creatinine (Scr), higher CKD stages, presence of proteinuria and CVD were risk factors for KRT endpoint; the increased age, decreased hemoglobin (Hb), decreased serum Alb were risk factors for all-cause death endpoint; the increased age, decreased serum Alb were risk factors for CVD events endpoint. Appropriate preventive or therapeutic interventions should be taken to control these predictive factors to delay the development of CKD complications, thereby improving the prognosis and reducing the disease burden of the high-risk populations.Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter cohort study, a total of 1138 pre-dialysis CKD patients were recruited. Patients were categorized into two groups according to the etiologies of DKD and non-diabetic kidney disease (NDKD). Propensity score matching was performed to adjust for confounding factors, resulting in 197 patients being assigned to DKD and NDKD groups, respectively. The primary endpoints were 50% estimated glomerular filtration rate (eGFR) decline and initiation of kidney replacement therapy (KRT). The secondary endpoints were all-cause death and the development of cardiovascular disease (CVD) events. We found that DKD patients have a higher risk to develop 50% eGFR decline endpoint (HR:2.30, 95%CI [1.48-3.58], p < 0.001) and KRT endpoint (HR:1.64, 95%CI [1.13-2.37], p < 0.05) than NDKD patients. The 3-year cumulative incidence of 50% eGFR decline and KRT endpoint was significantly higher in DKD patients (26.90% vs.13.71% and 35.03% vs. 22.34%, respectively). The Cox regression analyses showed that the increased systolic blood pressure (SBP), DKD, decreased serum albumin (Alb), and higher CKD stages were risk factors for the 50% eGFR decline endpoint; the increased SBP, DKD, decreased serum Alb, serum creatinine (Scr), higher CKD stages, presence of proteinuria and CVD were risk factors for KRT endpoint; the increased age, decreased hemoglobin (Hb), decreased serum Alb were risk factors for all-cause death endpoint; the increased age, decreased serum Alb were risk factors for CVD events endpoint. Appropriate preventive or therapeutic interventions should be taken to control these predictive factors to delay the development of CKD complications, thereby improving the prognosis and reducing the disease burden of the high-risk populations. |
| Author | Chen, Shengnan Chen, Lei Jiang, Hongli |
| Author_xml | – sequence: 1 givenname: Shengnan orcidid: 0000-0003-0635-7724 surname: Chen fullname: Chen, Shengnan organization: Department of Blood Purification, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University – sequence: 2 givenname: Lei surname: Chen fullname: Chen, Lei organization: Department of Blood Purification, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University – sequence: 3 givenname: Hongli surname: Jiang fullname: Jiang, Hongli organization: Department of Blood Purification, Kidney Hospital, The First Affiliated Hospital of Xi'an Jiaotong University |
| BookMark | eNqFktFuFCEUhiemxm6rj2BC4o03swVmmBk0MZq11cYmNaZNvCPAHHbZzsIKbJt9Kl9Rxt1etEa9gQS-_yPncI6KA-cdFMVLgqcEd_gEd12DKf0-pXmdUoKbrqVPiglhlJUNrvlBMRmZcoQOi6MYlxgTlqFnxWHFeNW1mE6Kn1-DnzsfbUTS9SjYeIOM1MmHiLxBehG8sxrd2N7BFvU2goyA1jkUIEbrHbIOrWWy4FJEdzYtMiQVpD9Doz8XUf7l_g2SozeuQSd7C0j7hQ8Jzb58LL9dXl-dopg2_fZ58dTIIcKL_X5cXJ-dXs0-lxeXn85nHy5KXTc8lVRChY1kGDSntAbeKaX62rCeGMNqBYq1XLakVU1bcdJD12ogqobclB60ro6L852393Ip1sGuZNgKL634feDDXMiQixhANJoxTqjhoGjdGNkZImtZAZVMqfxUdr3budYbtYJe51YFOTyQPrxxdiHm_lbwqiFti7Pg9V4Q_I8NxCRWNmoYBunAb6KgDeectR1mGX31CF36TXC5VYJmoMEtZVWm3u4onRseAxihbcqf6Mf37SAIFuOQifshE-OQif2Q5TR7lL4v5X-597ucdcaHlbzzYehFktvBBxOk0zaK6t-KX-Cx7sA |
| CitedBy_id | crossref_primary_10_2147_PPA_S537890 crossref_primary_10_1186_s12882_024_03518_w crossref_primary_10_7759_cureus_62118 crossref_primary_10_12968_jokc_2025_10_2_70 crossref_primary_10_1186_s13098_025_01726_4 crossref_primary_10_2147_DMSO_S452280 crossref_primary_10_3389_fendo_2024_1334418 crossref_primary_10_1186_s12884_024_06563_3 crossref_primary_10_7759_cureus_45615 crossref_primary_10_1016_j_amjms_2024_01_018 crossref_primary_10_3389_fendo_2025_1481977 crossref_primary_10_1016_j_numecd_2025_103907 crossref_primary_10_1038_s41598_024_77996_1 crossref_primary_10_1097_MNH_0000000000001035 crossref_primary_10_1007_s13410_025_01542_6 crossref_primary_10_3389_fendo_2024_1387993 crossref_primary_10_3390_metabo13020306 crossref_primary_10_3390_ph18081130 crossref_primary_10_3390_ijms251810222 crossref_primary_10_1002_2211_5463_13683 crossref_primary_10_1136_bmjdrc_2023_003721 crossref_primary_10_7717_peerj_16915 crossref_primary_10_7759_cureus_64404 crossref_primary_10_1007_s11845_023_03544_x crossref_primary_10_2337_dc25_0355 crossref_primary_10_1016_j_diabres_2025_112116 crossref_primary_10_1038_s41581_025_00993_8 crossref_primary_10_3389_fendo_2025_1493521 crossref_primary_10_7717_peerj_18436 crossref_primary_10_1080_0886022X_2025_2471016 crossref_primary_10_1001_jamahealthforum_2023_5445 crossref_primary_10_1186_s13244_024_01671_2 crossref_primary_10_1080_0886022X_2024_2394164 crossref_primary_10_3389_fimmu_2023_1113212 crossref_primary_10_3389_fmed_2024_1418075 crossref_primary_10_1186_s13098_025_01874_7 crossref_primary_10_1093_ckj_sfad194 crossref_primary_10_3389_fendo_2023_1285509 crossref_primary_10_2147_DMSO_S471940 |
| Cites_doi | 10.1210/endrev/bnz010 10.1016/S0140-6736(20)30045-3 10.1016/j.diabres.2021.109119 10.1186/1471-2369-14-152 10.1371/journal.pmed.1003104 10.3390/nu10010069 10.1371/journal.pone.0190493 10.1007/s00216-021-03192-z 10.1046/j.1523-1755.1999.00422.x 10.1038/s41598-018-29757-0 10.1016/j.diabres.2009.10.007 10.1053/j.ajkd.2018.12.044 10.1007/s10157-016-1251-2 10.1016/j.cbi.2021.109625 10.1186/s12872-021-02448-x 10.1016/j.clnu.2018.08.002 10.1016/S0140-6736(13)60687-X 10.1007/s10157-016-1261-0 10.3390/ijms221910822 10.1053/j.ajkd.2020.07.011 10.3390/nu9080829 10.1053/j.ajkd.2008.12.034 10.1016/j.kint.2020.10.012 10.1001/jama.2015.0602 10.1016/j.jchf.2021.06.017 |
| ContentType | Journal Article |
| Copyright | 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022 The Author(s) |
| Copyright_xml | – notice: 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022 – notice: 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022 The Author(s) |
| DBID | 0YH AAYXX CITATION 3V. 7T5 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1080/0886022X.2022.2106872 |
| DatabaseName | Taylor & Francis Open Access CrossRef ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database Research Library Research Library (Corporate) Proquest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 0YH name: Taylor & Francis Open Access url: https://www.tandfonline.com sourceTypes: Publisher – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | S. Chen et al |
| EISSN | 1525-6049 |
| EndPage | 1319 |
| ExternalDocumentID | oai_doaj_org_article_6c55912f9eb246fa8f1a4a3e2a5bb4be PMC9361770 10_1080_0886022X_2022_2106872 2106872 |
| Genre | Research Article |
| GroupedDBID | --- 00X 0YH 123 29P 36B 4.4 53G 5RE 7X7 88E 8FI 8FJ 8G5 ABDBF ABUWG ACGEJ ACGFS ACUHS ADBBV ADCVX ADRBQ ADXPE AENEX AFKRA AFKVX AJWEG ALMA_UNASSIGNED_HOLDINGS AOIJS AQTUD ARJSQ AZQEC BABNJ BCNDV BENPR BLEHA CCPQU CS3 DWQXO EAP EBC EBD EBS EMB EMK EMOBN EPL ESX F5P FYUFA GNUQQ GROUPED_DOAJ GUQSH H13 HMCUK HZ~ M1P M2O M4Z O9- P2P PHGZM PHGZT PIMPY PJZUB PPXIY PROAC PSQYO RPM SV3 TDBHL TFDNU TFL TFW TUS UKHRP V1S ~1N AAYXX AFFHD CITATION 3V. 7T5 7XB 8FK H94 K9. MBDVC PKEHL PQEST PQQKQ PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c469t-2ae30fa50ec9224e98bbbd4f5d1ff54beb579a717b67391de87ce1b4e702decc3 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 46 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000837585400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0886-022X 1525-6049 |
| IngestDate | Fri Oct 03 12:32:26 EDT 2025 Tue Nov 04 01:51:57 EST 2025 Wed Oct 01 17:13:26 EDT 2025 Tue Oct 07 07:27:37 EDT 2025 Sat Nov 29 02:26:01 EST 2025 Tue Nov 18 22:52:16 EST 2025 Mon Oct 20 23:46:15 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | open-access: http://creativecommons.org/licenses/by/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-2ae30fa50ec9224e98bbbd4f5d1ff54beb579a717b67391de87ce1b4e702decc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Supplemental data for this article can be accessed at https://doi.org/10.1080/0886022X.2022.2106872. |
| ORCID | 0000-0003-0635-7724 |
| OpenAccessLink | https://www.proquest.com/docview/2780607253?pq-origsite=%requestingapplication% |
| PMID | 35938702 |
| PQID | 2780607253 |
| PQPubID | 3933335 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_6c55912f9eb246fa8f1a4a3e2a5bb4be crossref_primary_10_1080_0886022X_2022_2106872 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9361770 proquest_miscellaneous_2699957805 crossref_citationtrail_10_1080_0886022X_2022_2106872 proquest_journals_2780607253 informaworld_taylorfrancis_310_1080_0886022X_2022_2106872 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-12-31 |
| PublicationDateYYYYMMDD | 2022-12-31 |
| PublicationDate_xml | – month: 12 year: 2022 text: 2022-12-31 day: 31 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York |
| PublicationTitle | Renal failure |
| PublicationYear | 2022 |
| Publisher | Taylor & Francis Taylor & Francis Ltd Taylor & Francis Group |
| Publisher_xml | – name: Taylor & Francis – name: Taylor & Francis Ltd – name: Taylor & Francis Group |
| References | Malek V (e_1_3_6_14_1) 2021 e_1_3_6_11_1 e_1_3_6_10_1 e_1_3_6_15_1 e_1_3_6_13_1 e_1_3_6_12_1 e_1_3_6_19_1 e_1_3_6_18_1 e_1_3_6_17_1 e_1_3_6_16_1 e_1_3_6_20_1 e_1_3_6_21_1 e_1_3_6_22_1 e_1_3_6_2_1 e_1_3_6_6_1 e_1_3_6_5_1 e_1_3_6_4_1 e_1_3_6_3_1 e_1_3_6_9_1 e_1_3_6_8_1 e_1_3_6_7_1 e_1_3_6_27_1 e_1_3_6_23_1 e_1_3_6_24_1 e_1_3_6_25_1 e_1_3_6_26_1 |
| References_xml | – ident: e_1_3_6_7_1 doi: 10.1210/endrev/bnz010 – ident: e_1_3_6_3_1 doi: 10.1016/S0140-6736(20)30045-3 – ident: e_1_3_6_6_1 doi: 10.1016/j.diabres.2021.109119 – ident: e_1_3_6_9_1 doi: 10.1186/1471-2369-14-152 – ident: e_1_3_6_4_1 doi: 10.1371/journal.pmed.1003104 – ident: e_1_3_6_21_1 doi: 10.3390/nu10010069 – ident: e_1_3_6_8_1 doi: 10.1371/journal.pone.0190493 – ident: e_1_3_6_27_1 doi: 10.1007/s00216-021-03192-z – ident: e_1_3_6_20_1 doi: 10.1046/j.1523-1755.1999.00422.x – ident: e_1_3_6_19_1 doi: 10.1038/s41598-018-29757-0 – ident: e_1_3_6_5_1 doi: 10.1016/j.diabres.2009.10.007 – ident: e_1_3_6_22_1 doi: 10.1053/j.ajkd.2018.12.044 – ident: e_1_3_6_16_1 doi: 10.1007/s10157-016-1251-2 – ident: e_1_3_6_15_1 doi: 10.1016/j.cbi.2021.109625 – ident: e_1_3_6_17_1 doi: 10.1186/s12872-021-02448-x – ident: e_1_3_6_26_1 doi: 10.1016/j.clnu.2018.08.002 – ident: e_1_3_6_2_1 doi: 10.1016/S0140-6736(13)60687-X – ident: e_1_3_6_11_1 doi: 10.1007/s10157-016-1261-0 – ident: e_1_3_6_13_1 doi: 10.3390/ijms221910822 – ident: e_1_3_6_23_1 doi: 10.1053/j.ajkd.2020.07.011 – ident: e_1_3_6_18_1 doi: 10.3390/nu9080829 – ident: e_1_3_6_10_1 doi: 10.1053/j.ajkd.2008.12.034 – ident: e_1_3_6_24_1 doi: 10.1016/j.kint.2020.10.012 – ident: e_1_3_6_25_1 doi: 10.1001/jama.2015.0602 – ident: e_1_3_6_12_1 doi: 10.1016/j.jchf.2021.06.017 – start-page: 31 volume-title: Reviews of physiology, biochemistry and pharmacology year: 2021 ident: e_1_3_6_14_1 |
| SSID | ssj0015872 |
| Score | 2.4981225 |
| Snippet | Diabetic kidney disease (DKD) is emerging rapidly as the leading cause of chronic kidney disease (CKD) worldwide. In this 3-year prospective, multicenter... |
| SourceID | doaj pubmedcentral proquest crossref informaworld |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 1310 |
| SubjectTerms | 50% eGFR decline all-cause death Blood pressure Cardiovascular diseases Clinical Study Creatinine CVD events Diabetes Diabetes mellitus Diabetic kidney disease Dialysis Epidermal growth factor receptors Glomerular filtration rate Hemoglobin Kidney diseases kidney replacement therapy non-diabetic kidney disease Prognosis Proteinuria Risk factors Therapeutic applications |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9UwEA6yiPgi6w3rrhLB165tkubim667COKyDwrnLSRpgkXpkXO6gr_Kv-hMmx5OFTkvvjaXdjqTZCaZfB8hL1uIegImtQcuZClCbEvPuCy9rhOvk2uq1I5kE-rqSq9W5nqP6gtzwiZ44OnHvZIBfN6aJQMhoJDJ6VQ74XhkrvFe-IizL3g9czCVzw8aPdI2wRDCFFu2mu_uIKq2RtoltoLYkLEziHikVmyxKo3g_X9Aly4c0GX65N56dHlM7mVHkr6ZBLhPbsX-AbnzMR-VPyS_rjdrTKLrttT1LcUUcprJdeg60TCB4tKvXdvHnzSf09AxXWuC6qBdTzPq6pbidi2d9mn_boT99-u-_Ef5a-qw3_lOJ0VO3s1Azz-8KxGU-YKOELePyOfLi0_n78vMzlAGCKmHkrnIK1RmDAb8gGi0974VqWnrlBrQjG-UcRAteqm4qduoVYi1F1FVrAXD4Y_JEXxbfEKok04mrUUTHMZ3xrjKp-gqnuAlOsqCiFk7NmTocmTQ-GbrGeE0K9WiUm1WakHOds2-T9gdhxq8RdXvKiP09vgADNJmg7SHDLIgZt9w7DDuvKSJJsXyAx9wOluZzXPJ1jKlK1kp1vCCvNgVwyyARzuuj-sbqCPB0W-Qn6IgamGdC2GWJX33ZcQTNxzcWFU9_R_Sn5C7KNAEhXlKjobNTXxGbocfQ7fdPB8H6W-2zkKa priority: 102 providerName: Directory of Open Access Journals – databaseName: Taylor and Francis Online Journals dbid: TFW link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Ni9UwFA0yiLhx_MTqKBHcdmyTNh_udJyHIA6zGPHtQpImWpRW2s6Av8q_aG6aPqbKMAtdvpfeNCE3NznJ7TkIvWwC6rGQ1G5pxfLKuiY3hLLciNLT0uu68E0Um-AnJ2K7lacpm3BMaZWAof1MFBFjNUxubcYlI-5VmBgsLD3bgO4IOQyYhQkOUTgs_aBhcLb5vLtHqEWUbwKLHEyWb3iuqmW1OkUS_z8oTFcb0XUa5aV1abP_H3p0F91Jm1L8Zvaie-iG6-6jWx_TtfsD9Ot06CEhrx1xeAWGdHSchHpw77GdCXbxt7bp3E-c7nxwTP2aaT9w2-HE4DpiOPrF85nv30ZQf9d3-RXlr7GGepfvQzHo-w4TPvrwLgeC52Mc6XIfok-b47Oj93lSeshtgOdTTrSjBTiGszLsKZwUxpim8nVTel9XxpmaSx2Qp2GcyrJxgltXmsrxgjTBCekjtBfa5h4jrJlmXoiqthqwopS6MN7pgvrwEuFYhqplhJVNNOigxvFdlQtbahoMBYOh0mBk6HBn9mPmAbnO4C24z-5hoPGOf_TDF5WigmI2ALqSeOkMqZjXwpe60tQRXRsTup0hedn51BRPcfwsuaLoNQ04WDxVpbg0KsJFwQpOapqhF7viEFHgmkh3rj8Pz7AAGmrQusgQX3n4qjPrkq79GrnJJQ1bYl48-YeGP0W34efMpnmA9qbh3D1DN-3F1I7D8zi_fwMFRlIM priority: 102 providerName: Taylor & Francis |
| Title | Prognosis and risk factors of chronic kidney disease progression in patients with diabetic kidney disease and non-diabetic kidney disease: a prospective cohort CKD-ROUTE study |
| URI | https://www.tandfonline.com/doi/abs/10.1080/0886022X.2022.2106872 https://www.proquest.com/docview/2780607253 https://www.proquest.com/docview/2699957805 https://pubmed.ncbi.nlm.nih.gov/PMC9361770 https://doaj.org/article/6c55912f9eb246fa8f1a4a3e2a5bb4be |
| Volume | 44 |
| WOSCitedRecordID | wos000837585400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: DOA dateStart: 20160101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: 7X7 dateStart: 20171101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: BENPR dateStart: 20171101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: PIMPY dateStart: 20171101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: M2O dateStart: 20171101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVAWR databaseName: Taylor & Francis Open Access customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: 0YH dateStart: 19870101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis – providerCode: PRVAWR databaseName: Taylor and Francis Online Journals customDbUrl: eissn: 1525-6049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0015872 issn: 0886-022X databaseCode: TFW dateStart: 20170101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1db9MwFLVYh9Be-EYrjMpIvGYkdmI7vCA2Wg2hlggN0T1FtmNDBUpG0yHxq_iL-DpOWUCwB14sNY4TWz258f3IOQg9rZzXo6GoXdOURak2VaQIZZESiaWJlVlsKy82wRcLsVzmRQi4taGssreJ3lBXjYYY-TPCRcxiTjL64vxrBKpRkF0NEho7aBeYytIR2j2aLop32zxCJrx8k3uUoNSWLPtveIBdW4D8Elk6H5GQQ-f5MMHJ4O3kSfx_ozAdbESHZZSX3kuzW_-7otvoZtiR4pcdhO6ga6a-i27MQ879HvpRrBuoxlu1WNYVhlp0HFR6cGOx7th18edVVZvvOCR8sK_76jg_8KrGgb61xRD3xV3A989BcP26qaO_9D_HEq7bfxyKQdx3vcHHb15FwO48xZ4r9z56P5ueHp9EQeYh0s4330REGhoDKozO3YbC5EIpVaU2qxJrs1QZlfFcOrdTMU7zpDKCa5Oo1PCYVA6B9AEaubmZfYQlk8wKkWZagqOY5zJW1siYWncTYdgYpf3fW-rAgQ5SHF_KpKdKDagoARVlQMUYHW6HnXckIFcNOALsbE8GDm9_oFl_LINJKJl23lxCbG4USZmVwiYyldQQmSnllj1G-WXklRsfwrGd3kpJr5jAQY-5MhiltvwFuDF6su125gRyRLI2zYU7hzmPIQOhizHiA3gPFjPsqVefPDF5Tt1-mMcP_33zR2gPptqxZR6g0WZ9YR6j6_rbZtWuJ2gnPjtxLV9y34pJeKYnPlzi2jl5644Vr-fFmft1OvvwE11YWDk |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1db9UgGCZzGvXGb2N1KiZ62a2FFqiJMbqPbDnbyS5mcu4QKGijaec5nWZ_Sv-ivC09rhrd1S68LYUCfXnhgZfnQeh56VGPgaB2QzMWZ8aWsSaUxVqkjqZO5YkrO7EJPp2K2aw4XEHfh7swEFY5-MTOUZeNgT3yDcJFwhJOcvr6-EsMqlFwujpIaPRmMbGn3zxkW7za2_L_9wUhO9tHm7txUBWIjYeCbUyUpQlUwprCz1-2EFrrMnN5mTqXZ9rqnBfKoxzNOC3S0gpubKozyxNS-gZTX-4ldNn7cQ4hZHy2BHhpLjqxKD9wIbCXzIYbQ8DlLUDsicw8IiVk3eMsJjgZzYWdZMBvhKmjZe84aPPMLLhz83_rv1voRlhv4zf9ALmNVmx9B109CBEFd9GPw3kDsYbVAqu6xBBpj4MGEW4cNj13MP5UlbU9xeE4C3dRbT2jCa5qHMhpFxh2tXG_nf1nJii_bur4L-kvsYJyh6uvGKSL5y3enGzFwF29jTsm4Hvo3YV013206utmHyCsmGJOiCw3CmBwUahEO6sS6vxHhGURygZzkiYwvIPQyGeZDkSwwQolWKEMVhih9WW2457i5LwMb8FWly8DQ3n3oJl_kMHhSWY8Vk2JK6wmGXNKuFRlilqicq19syNUnLV02XYbVK5Xk5H0nAqsDTYug8tdyF8GHqFny2TvLOEETNW2OfHvMI-HcpDxiBAfDadRY8YpdfWxo10vqF_t8-Thvz_-FF3bPTrYl_t708kjdB2q3fOCrqHVdn5iH6Mr5mtbLeZPOt-B0fuLHmw_AQzlr4s |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQQRUX3oiUAkbimpLYiR_coO0KVFjtoYi9WbZjQwRKqmxaiV_FX8STOKsGVPUA1zjjhzwez2ePv0HoVRVQj4WgdksLlhbWVakhlKVG5J7mXpeZr4ZkE3y5FOu1XMVowk0MqwQM7UeiiMFWw-I-q_wUEfc6LAwWtp51QHeEHATMwgQPVvhmcJ0Z4K_TxZftRUIphvxNIJKCzPSI56pqZtvTwOL_B4fpzBOdx1Fe2pgWd__DkO6hO9ErxW9HNbqPbrjmAdr9FO_dH6Jfq66FiLx6g0MTGOLRcczUg1uP7ciwi7_XVeN-4njpg4fYr5H3A9cNjhSuGwxnv3g89P1bCOpv2ia9ovwN1lDv9EAUQ4LfrseHJ0cpMDwf44Ev9xH6vDg-PXyfxlQPqQ34vE-JdjQDzXBWBqfCSWGMqQpfVrn3ZWGcKbnUAXoaxqnMKye4dbkpHM9IFbSQPkY7oW_uCcKaaeaFKEqrASxKqTPjnc6oD40IxxJUTDOsbORBh3QcP1Q-0aXGyVAwGSpORoIOtmJnIxHIdQLvQH22PwOP9_Ch7b6qaBYUswHR5cRLZ0jBvBY-14WmjujSmDDsBMnLyqf64RjHjzlXFL2mA_uTpqpomDaKcJGxjJOSJujltjiYFLgn0o1rz8M_LKCGEpJdJIjPNHw2mHlJU38byMklDT4xz_b-oeMv0O7qaKE-fliePEW3oWRk1txHO3137p6hW_airzfd82Gp_wbvx1To |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognosis+and+risk+factors+of+chronic+kidney+disease+progression+in+patients+with+diabetic+kidney+disease+and+non-diabetic+kidney+disease%3A+a+prospective+cohort+CKD-ROUTE+study&rft.jtitle=Renal+failure&rft.au=Chen%2C+Shengnan&rft.au=Chen%2C+Lei&rft.au=Jiang%2C+Hongli&rft.date=2022-12-31&rft.issn=0886-022X&rft.eissn=1525-6049&rft.volume=44&rft.issue=1&rft.spage=1310&rft.epage=1319&rft_id=info:doi/10.1080%2F0886022X.2022.2106872&rft.externalDBID=n%2Fa&rft.externalDocID=10_1080_0886022X_2022_2106872 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0886-022X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0886-022X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0886-022X&client=summon |