Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway

Background: Idiopathic pulmonary fibrosis is a severe and deadly form of diffuse parenchymal lung disease and treatment options are few. Alveolar epithelial type 2 (AEC2) cell senescence is implicated in the pathogenies of IPF. A major bioactive compound from the traditional Chinese medicine Fructus...

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Bibliographic Details

Published in:	Frontiers in pharmacology Vol. 14; p. 1141800
Main Authors:	Xiong, Dian, Gao, Fei, Shao, Jingbo, Pan, Yueyun, Wang, Song, Wei, Dong, Ye, Shugao, Chen, Yuan, Chen, Rui, Yue, Bingqing, Li, Juan, Chen, Jingyu
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 14.03.2023
Subjects:	alveolar epithelial type 2 cells arctiin cellular senescence DSPE-PEG idiopathic pulmonary fibrosis nanoparticle Pharmacology arctiin DSPE-PEG cellular senescence alveolar epithelial type 2 cells nanoparticle traditional Chinese medicine idiopathic pulmonary fibrosis p38/p53/p21 signaling axis
ISSN:	1663-9812, 1663-9812
Online Access:	Get full text
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