Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires

The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive immune responses, activated B cells duplicate and undergo somatic hypermutation in their B-cell receptor (BCR) genes, resulting in clonal fam...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1123968
Main Authors:	Pelissier, Aurelien, Luo, Siyuan, Stratigopoulou, Maria, Guikema, Jeroen E. J., Rodríguez Martínez, María
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 17.04.2023
Subjects:	analysis B-cell B-Lymphocytes clone Clone Cells clustering diversity Gene Library Immunoglobulins - genetics Immunology Receptors, Antigen, B-Cell repertoire diversity antibody RNA B-cell clone clustering repertoire analysis
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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