Thermal and magnetic properties of iron oxide colloids: influence of surfactants

Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of abou...

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Vydané v:Nanotechnology Ročník 26; číslo 42; s. 425704 - 425714
Hlavní autori: I P Soares, Paula, Lochte, Frederik, Echeverria, Coro, C J Pereira, Laura, T Coutinho, Joana, M M Ferreira, Isabel, M M Novo, Carlos, P M R Borges, João
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England IOP Publishing 23.10.2015
Predmet:
Animals
Cell Survival - drug effects
Cercopithecus aethiops
Colloids - chemistry
Colloids - toxicity
Hot Temperature
hyperthermia
iron oxide nanoparticles
magnetic characterization
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - toxicity
Surface-Active Agents - chemistry
Vero Cells
ISSN:0957-4484, 1361-6528, 1361-6528
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Abstract Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.
AbstractList Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.
Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate. The influence of both stabilizers on the heating ability and in vitro cytotoxicity of the produced iron oxide NPs was assessed. Physicochemical characterization of the samples confirmed that the used surfactants do not change the particles' average size and that the presence of the surfactants has a strong effect on both the magnetic properties and the heating ability. The heating ability of Fe3O4 NPs shows a proportional increase with the increase of iron concentration, although when coated with trisodium citrate or oleic acid the heating ability decreases. Cytotoxicity assays demonstrated that both pristine and trisodium citrate Fe3O4 samples do not reduce cell viability. However, oleic acid Fe3O4 strongly reduces cell viability, more drastically in the SaOs-2 cell line. The produced iron oxide NPs are suitable for cancer hyperthermia treatment and the use of a surfactant brings great advantages concerning the dispersion of NPs, also allowing better control of the hyperthermia temperature.
Author C J Pereira, Laura
M M Ferreira, Isabel
T Coutinho, Joana
P M R Borges, João
Lochte, Frederik
I P Soares, Paula
Echeverria, Coro
M M Novo, Carlos
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  surname: I P Soares
  fullname: I P Soares, Paula
  organization: Universidade Nova de Lisboa CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, 2829-516 Caparica, Portugal
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  givenname: Frederik
  surname: Lochte
  fullname: Lochte, Frederik
  organization: Universidade Nova de Lisboa CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, 2829-516 Caparica, Portugal
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  givenname: Coro
  surname: Echeverria
  fullname: Echeverria, Coro
  organization: Universidade Nova de Lisboa CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, 2829-516 Caparica, Portugal
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  givenname: Laura
  surname: C J Pereira
  fullname: C J Pereira, Laura
  organization: Universidade de Lisboa IST/C2TN, Instituto Superior Técnico, Estrada Nacional 10, ao km 139,7, 2695-066 Bobadela LRS, Portugal
– sequence: 5
  givenname: Joana
  surname: T Coutinho
  fullname: T Coutinho, Joana
  organization: Universidade de Lisboa IST/C2TN, Instituto Superior Técnico, Estrada Nacional 10, ao km 139,7, 2695-066 Bobadela LRS, Portugal
– sequence: 6
  givenname: Isabel
  surname: M M Ferreira
  fullname: M M Ferreira, Isabel
  email: imf@fct.unl.pt
  organization: Universidade Nova de Lisboa CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, 2829-516 Caparica, Portugal
– sequence: 7
  givenname: Carlos
  surname: M M Novo
  fullname: M M Novo, Carlos
  organization: Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, IHMT/UNL, 1349-008 Lisboa, Portugal
– sequence: 8
  givenname: João
  surname: P M R Borges
  fullname: P M R Borges, João
  email: jpb@fct.unl.pt
  organization: Universidade Nova de Lisboa CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, 2829-516 Caparica, Portugal
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26421876$$D View this record in MEDLINE/PubMed
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SubjectTerms Animals
Cell Survival - drug effects
Cercopithecus aethiops
Colloids - chemistry
Colloids - toxicity
Hot Temperature
hyperthermia
iron oxide nanoparticles
magnetic characterization
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - toxicity
Surface-Active Agents - chemistry
Vero Cells
Title Thermal and magnetic properties of iron oxide colloids: influence of surfactants
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