Physiochemical properties and application of hyaluronic acid: a systematic review

Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness througho...

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Vydané v:	Journal of cosmetic dermatology Ročník 15; číslo 4; s. 520 - 526
Hlavní autori:	Salwowska, Natalia M, Bebenek, Katarzyna A, Żądło, Dominika A, Wcisło-Dziadecka, Dominika L
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Blackwell Publishing Ltd 01.12.2016
Predmet:	adjuvant therapy bioavailability Biological Availability Cosmetic Techniques Dermal Fillers - adverse effects Dermal Fillers - pharmacokinetics Dermal Fillers - therapeutic use Dry Eye Syndromes - drug therapy Humans hyaluronic acid Hyaluronic Acid - adverse effects Hyaluronic Acid - metabolism Hyaluronic Acid - pharmacokinetics Hyaluronic Acid - therapeutic use long-lasting effect Neoplasms - metabolism Osteoarthritis - drug therapy Randomized Controlled Trials as Topic tolerability Viscosupplements - adverse effects Viscosupplements - pharmacokinetics Viscosupplements - therapeutic use wound healing adjuvant therapy long-lasting effect wound healing bioavailability tolerability hyaluronic acid
ISSN:	1473-2130, 1473-2165, 1473-2165
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Abstract	Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners. Methods We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria. Findings Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long‐lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved. Conclusions Adjunct therapy with hyaluronic acid provides longer‐lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well‐established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields.
AbstractList	Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. Objective We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners. Methods We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria. Findings Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long‐lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved. Conclusions Adjunct therapy with hyaluronic acid provides longer‐lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well‐established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields. Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine.BACKGROUNDHyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine.We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners.OBJECTIVEWe aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners.We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria.METHODSWe conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria.Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long-lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved.FINDINGSFactors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long-lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved.Adjunct therapy with hyaluronic acid provides longer-lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well-established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields.CONCLUSIONSAdjunct therapy with hyaluronic acid provides longer-lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well-established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields. Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout several fields of medicine. We aim to investigate the application of hyaluronic acid and its effectiveness throughout several fields of medicine, including several therapies administered and prescribed by general health practitioners. We conducted a systematic review on randomized controlled trials about the physiochemical properties of hyaluronic acid and its application through primary care. Studies included in this review were peer reviewed and met our inclusion criteria. Factors were clustered into the following: uses throughout several fields of medicine, physiochemical properties, bioavailability, tolerance, effectiveness, and adverse effects. Therapies with hyaluronic acid provided long-lasting, pain relieving, moisturizing, lubricating, and dermal filling effect. Tissue hydration, elasticity, and durability improved. Adjunct therapy with hyaluronic acid provides longer-lasting therapeutic effect when compared to the use of glucocorticosteroids and NSAIDs in osteoarthritic chronic diseases, is well-established in ophthalmology due to its lubricating properties for the corneal endothelium, and improves tissue hydration and cellular resistance to mechanical damage in aesthetic dermatology, and has marginal adverse effects. Several trials indicated its role in tumor markers, liver diseases, and in pharmaceuticals, but further research would be necessary to draw conclusive results in those fields.
Author	Wcisło-Dziadecka, Dominika L Salwowska, Natalia M Bebenek, Katarzyna A Żądło, Dominika A
Author_xml	– sequence: 1 givenname: Natalia M surname: Salwowska fullname: Salwowska, Natalia M organization: Department of Dermatology, Andrzej Mielęcki Memorial Independent Public Clinical Hospital in Katowice, Katowice, Poland – sequence: 2 givenname: Katarzyna A surname: Bebenek fullname: Bebenek, Katarzyna A organization: Department of Medicine, Adventist Hinsdale Hospital, IL, Hinsdale, USA – sequence: 3 givenname: Dominika A surname: Żądło fullname: Żądło, Dominika A organization: Department of General and Endocrine Surgery, School of Medicine in Bytom Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland – sequence: 4 givenname: Dominika L surname: Wcisło-Dziadecka fullname: Wcisło-Dziadecka, Dominika L email: ddziadecka@interia.pl, ddziadecka@interia.pl organization: Department of Skin Structural Studies, Chair of Cosmetology, School of Pharmacy with Division of Medicine in Sosnowiec, Medical University of Silesia, Sosnowiec, Poland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27324942$$D View this record in MEDLINE/PubMed
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Keywords	adjuvant therapy long-lasting effect wound healing bioavailability tolerability hyaluronic acid
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PublicationTitle	Journal of cosmetic dermatology
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References	Toole BP. Hyaluronan: from the extracellular glue that pericellular cue. Nat Rev Cancer 2004; 4: 528-39. Kultti A, Xiaoming L, Ping J et al. Therapeutic targeting of hyaluronan in the tumor stroma. Cancers 2012; 4: 873-903. Stern R, Asari AA, Sugahara SC. Hyaluronan fragments: an information-rich system. Eur J Cell Biol 2006; 85: 699-715. Juhlin L. Hyaluronan in skin. J Intern Med 1997; 242: 61-6. Maxwell C, McCarthy J, Turley E. Cell-surface and mitotic spindle RHAMM: moonlighting or dual oncogenic functions? J Cell Sci 2008; 121: 925-32. Jacobetz MA, Chan DS, Neesse A et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013; 62: 112-20. Moore AR, Willoughby DA. Hyaluronan as a drug delivery system for diclofenac: a hypothesis for the mode of action. Int J Tissue React 1995; 17: 153-6. Jiang P, Li X, Thompson CB et al. Effective targeting of the tumor microenvironment for cancer therapy. Anticancer Res 2012; 32: 1203-12. Lepperdinger G, Strobl B, Kreil G. HYAL2, and the human gene Expressed in many cells, encodes a lysosomal Hyaluronidase with a novel type of specificity. J Biol Chem 1998; 273: 22466-70. Hardwick C, Hoare K, Owens R et al. Molecular cloning of a novel hyaluronan receptor mediates tumor cell that motility. J Cell Biol 1992; 117: 1343-50. Saari H, Konttinen YT. Determination of synovial fluid hyaluronate concentration and polymerisation by high performance liquid chromatography. Ann Rheum Dis 1989; 48: 565-70. Volpi N, Schiller J, Stern R et al. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem 2009; 16: 1718-45. Lokeshwar VB, Cerwinka WH, Isoyama T et al. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Cancer Res 2005; 65: 7782-9. Kanchwala SK, Holloway L, Bucky LP. Reliable soft tissue augmentation: a clinical comparison of injectable soft-tissue fillers for facial-volume augmentation. Ann Plast Surg 2005; 55: 30-5. Schiavinato A, Lini E, Guidolin D et al. Intraarticular sodium hyaluronate injections in the Pond-Nuki experimental model of osteoarthritis in dogs. II. Morphological findings. Clin Orthop Relat Res 1989; 241: 286-99. Kogan G, Soltes L, Stern R et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 2007; 29: 17-25. van Beek M, Weeks A, Jones L et al. Immobilized hyaluronic acid containing model silicone hydrogels reduce protein adsorption. J Biomater Sci Polym Ed 2008; 19: 1425-36. Prehm P. Release of hyaluronate from eukaryotic cells. Biochem J 1990; 267: 185-9. Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 2003; 5: 54-67. Szabó A, Zelkó R, Antal I. Treatment of rheumatic diseases with intraarticular drug delivery systems. Acta Pharm Hung 2011; 81: 77-86. Lathrop WF, Carmichael EP, Myles DG et al. cDNA cloning reveals the molecular structure of a sperm surface protein PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. J Cell Biol 1990; 111: 2939-49. Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther 2008; 10: 35-42. Hamerman D, Schuster H. Hyaluronate in normal human synovial fluid. J Clin Invest 1958; 37: 57-64. Barbucci R, Lamponi S, Borzacchiello A et al. Hyaluronic acid hydrogel in the treatment of osteoarthritis. Biomaterials 2002; 23: 4503-13. Ghosh P, Holbert C, Read R et al. Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J Rheumatol Suppl 1995; 43: 155-7. Bates EJ, Harper GS, Lowther DA et al. Effect of oxygen-derived reactive species on cartilage proteoglycan-hyaluronate aggregates. Biochem Int 1984; 8: 629-37. Balogh L, Polyak A, Mathe D et al. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem 2008; 56: 10582-93. Meyer F, Palmer JW. The polysaccharide of the vitreous humor. J Biol Chem 1934; 107: 629-34. Weissmann B, Meyer K. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc 1954; 76: 1753-7. Koyama H, Hibi T, Isogai Z et al. Hyperproduction of hyaluronan in neu-induced mammary tumor angiogenesis accelerates through stromal cell recruitment: possible involvement of versican/PG-M. Am J Pathol 2007; 170: 1086-99. Jacobson A, Rahmanian M, Rubin K et al. Expression of hyaluronan synthase 2 or Hyaluronidase 1 differentially: affect the growth rate of colon carcinoma cell transplantable tumors. Int J Cancer 2002; 102: 212-9. Maclennan AP. The production of capsules, hyaluronic acid and Hyaluronidase to 25 strains of group C streptococci. J Gen Microbiol 1956; 15: 485-91. Washburn NR, Prata JE, Friedrich EE et al. Polymer-conjugated inhibitors of tumor necrosis factor-α for local control of inflammation. Biomatter 2013; 3: e25597. Andre P. New trends in face rejuvenation by hyaluronic acid injections. J Cosmet Dermatol 2008; 7: 251-8. Gupta S, Hawker GA, Laporte A et al. The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of Individuals living with this condition. Rheumatology 2005; 44: 1531-7. Maltese A, Borzacchiello A, Mayol L et al. Novel polysaccharides-based viscoelastic formulations for ophthalmic surgery: rheological characterization. Biomaterials 2006; 27: 5134-42. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998; 25: 2203-12. Slevin M, Krupinski J, Gaffney J et al. Hyaluronan mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol 2007; 26: 58-68. Sugahara SC, Murai T, Nishinakamura H et al. Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells. J Biol Chem 2003; 278: 32259-65. Hemming R, Martin DC, Słomiński E et al. Mouse HYAL3 it encodes a 45-56-kDa glycoprotein overexpression increases whose hyaluronidase 1 activity in cultured cells. Glycobiology 2008; 18: 280-9. Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep 2000; 2: 466-71. 2013; 3 1995; 17 1958; 37 2008; 18 2013; 62 2011; 81 2008; 19 1934; 107 2004; 4 1998 2008; 56 2008; 7 1956; 15 2005; 65 2000; 2 2008; 10 1989; 48 1990; 267 2008; 121 2003; 278 2012; 32 2005; 44 1998; 25 1998; 273 2007; 29 2006; 85 2007; 170 2002; 102 2002; 23 1984; 8 2006; 27 1997; 242 1989; 241 1954; 76 1995; 43 1992; 117 2003; 5 2012; 4 1990; 111 2009; 16 2005; 55 2007; 26 Belmonte C (e_1_2_3_31_1) 1998 Schiavinato A (e_1_2_3_34_1) 1989; 241 e_1_2_3_2_1 e_1_2_3_6_1 e_1_2_3_16_1 e_1_2_3_39_1 e_1_2_3_5_1 e_1_2_3_17_1 e_1_2_3_38_1 e_1_2_3_4_1 Hardwick C (e_1_2_3_19_1) 1992; 117 e_1_2_3_3_1 e_1_2_3_12_1 e_1_2_3_35_1 e_1_2_3_9_1 e_1_2_3_13_1 e_1_2_3_8_1 e_1_2_3_14_1 e_1_2_3_37_1 e_1_2_3_7_1 e_1_2_3_15_1 e_1_2_3_36_1 e_1_2_3_10_1 Bates EJ (e_1_2_3_27_1) 1984; 8 e_1_2_3_11_1 Ghosh P (e_1_2_3_30_1) 1995; 43 Szabó A (e_1_2_3_33_1) 2011; 81 e_1_2_3_40_1 Jiang P (e_1_2_3_18_1) 2012; 32 Moore AR (e_1_2_3_29_1) 1995; 17 Altman RD (e_1_2_3_32_1) 1998; 25 e_1_2_3_28_1 e_1_2_3_23_1 e_1_2_3_24_1 e_1_2_3_25_1 e_1_2_3_26_1 e_1_2_3_42_1 e_1_2_3_20_1 e_1_2_3_41_1 e_1_2_3_21_1 e_1_2_3_22_1 e_1_2_3_43_1
References_xml	– reference: Washburn NR, Prata JE, Friedrich EE et al. Polymer-conjugated inhibitors of tumor necrosis factor-α for local control of inflammation. Biomatter 2013; 3: e25597. – reference: Andre P. New trends in face rejuvenation by hyaluronic acid injections. J Cosmet Dermatol 2008; 7: 251-8. – reference: Volpi N, Schiller J, Stern R et al. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem 2009; 16: 1718-45. – reference: Moore AR, Willoughby DA. Hyaluronan as a drug delivery system for diclofenac: a hypothesis for the mode of action. Int J Tissue React 1995; 17: 153-6. – reference: Schiavinato A, Lini E, Guidolin D et al. Intraarticular sodium hyaluronate injections in the Pond-Nuki experimental model of osteoarthritis in dogs. II. Morphological findings. Clin Orthop Relat Res 1989; 241: 286-99. – reference: Hardwick C, Hoare K, Owens R et al. Molecular cloning of a novel hyaluronan receptor mediates tumor cell that motility. J Cell Biol 1992; 117: 1343-50. – reference: Maxwell C, McCarthy J, Turley E. Cell-surface and mitotic spindle RHAMM: moonlighting or dual oncogenic functions? J Cell Sci 2008; 121: 925-32. – reference: Lathrop WF, Carmichael EP, Myles DG et al. cDNA cloning reveals the molecular structure of a sperm surface protein PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. J Cell Biol 1990; 111: 2939-49. – reference: Juhlin L. Hyaluronan in skin. J Intern Med 1997; 242: 61-6. – reference: Jacobetz MA, Chan DS, Neesse A et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 2013; 62: 112-20. – reference: Prehm P. Release of hyaluronate from eukaryotic cells. Biochem J 1990; 267: 185-9. – reference: Szabó A, Zelkó R, Antal I. Treatment of rheumatic diseases with intraarticular drug delivery systems. Acta Pharm Hung 2011; 81: 77-86. – reference: Kultti A, Xiaoming L, Ping J et al. Therapeutic targeting of hyaluronan in the tumor stroma. Cancers 2012; 4: 873-903. – reference: Barbucci R, Lamponi S, Borzacchiello A et al. Hyaluronic acid hydrogel in the treatment of osteoarthritis. Biomaterials 2002; 23: 4503-13. – reference: Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 2003; 5: 54-67. – reference: Meyer F, Palmer JW. The polysaccharide of the vitreous humor. J Biol Chem 1934; 107: 629-34. – reference: Toole BP. Hyaluronan: from the extracellular glue that pericellular cue. Nat Rev Cancer 2004; 4: 528-39. – reference: Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998; 25: 2203-12. – reference: Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep 2000; 2: 466-71. – reference: Maclennan AP. The production of capsules, hyaluronic acid and Hyaluronidase to 25 strains of group C streptococci. J Gen Microbiol 1956; 15: 485-91. – reference: Ghosh P, Holbert C, Read R et al. Hyaluronic acid (hyaluronan) in experimental osteoarthritis. J Rheumatol Suppl 1995; 43: 155-7. – reference: Weissmann B, Meyer K. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc 1954; 76: 1753-7. – reference: Kanchwala SK, Holloway L, Bucky LP. Reliable soft tissue augmentation: a clinical comparison of injectable soft-tissue fillers for facial-volume augmentation. Ann Plast Surg 2005; 55: 30-5. – reference: Jiang P, Li X, Thompson CB et al. Effective targeting of the tumor microenvironment for cancer therapy. Anticancer Res 2012; 32: 1203-12. – reference: Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther 2008; 10: 35-42. – reference: Stern R, Asari AA, Sugahara SC. Hyaluronan fragments: an information-rich system. Eur J Cell Biol 2006; 85: 699-715. – reference: Hamerman D, Schuster H. Hyaluronate in normal human synovial fluid. J Clin Invest 1958; 37: 57-64. – reference: Gupta S, Hawker GA, Laporte A et al. The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of Individuals living with this condition. Rheumatology 2005; 44: 1531-7. – reference: Kogan G, Soltes L, Stern R et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 2007; 29: 17-25. – reference: Hemming R, Martin DC, Słomiński E et al. Mouse HYAL3 it encodes a 45-56-kDa glycoprotein overexpression increases whose hyaluronidase 1 activity in cultured cells. Glycobiology 2008; 18: 280-9. – reference: Lokeshwar VB, Cerwinka WH, Isoyama T et al. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Cancer Res 2005; 65: 7782-9. – reference: Sugahara SC, Murai T, Nishinakamura H et al. Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells. J Biol Chem 2003; 278: 32259-65. – reference: Koyama H, Hibi T, Isogai Z et al. Hyperproduction of hyaluronan in neu-induced mammary tumor angiogenesis accelerates through stromal cell recruitment: possible involvement of versican/PG-M. Am J Pathol 2007; 170: 1086-99. – reference: Maltese A, Borzacchiello A, Mayol L et al. Novel polysaccharides-based viscoelastic formulations for ophthalmic surgery: rheological characterization. Biomaterials 2006; 27: 5134-42. – reference: Saari H, Konttinen YT. Determination of synovial fluid hyaluronate concentration and polymerisation by high performance liquid chromatography. Ann Rheum Dis 1989; 48: 565-70. – reference: Slevin M, Krupinski J, Gaffney J et al. Hyaluronan mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol 2007; 26: 58-68. – reference: Balogh L, Polyak A, Mathe D et al. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem 2008; 56: 10582-93. – reference: van Beek M, Weeks A, Jones L et al. Immobilized hyaluronic acid containing model silicone hydrogels reduce protein adsorption. J Biomater Sci Polym Ed 2008; 19: 1425-36. – reference: Lepperdinger G, Strobl B, Kreil G. HYAL2, and the human gene Expressed in many cells, encodes a lysosomal Hyaluronidase with a novel type of specificity. J Biol Chem 1998; 273: 22466-70. – reference: Jacobson A, Rahmanian M, Rubin K et al. Expression of hyaluronan synthase 2 or Hyaluronidase 1 differentially: affect the growth rate of colon carcinoma cell transplantable tumors. Int J Cancer 2002; 102: 212-9. – reference: Bates EJ, Harper GS, Lowther DA et al. Effect of oxygen-derived reactive species on cartilage proteoglycan-hyaluronate aggregates. Biochem Int 1984; 8: 629-37. – volume: 121 start-page: 925 year: 2008 end-page: 32 article-title: Cell‐surface and mitotic spindle RHAMM: moonlighting or dual oncogenic functions? publication-title: J Cell Sci – volume: 32 start-page: 1203 year: 2012 end-page: 12 article-title: Effective targeting of the tumor microenvironment for cancer therapy publication-title: Anticancer Res – volume: 241 start-page: 286 year: 1989 end-page: 99 article-title: Intraarticular sodium hyaluronate injections in the Pond‐Nuki experimental model of osteoarthritis in dogs. II. Morphological findings publication-title: Clin Orthop Relat Res – volume: 267 start-page: 185 year: 1990 end-page: 9 article-title: Release of hyaluronate from eukaryotic cells publication-title: Biochem J – volume: 25 start-page: 2203 year: 1998 end-page: 12 article-title: Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group publication-title: J Rheumatol – volume: 111 start-page: 2939 year: 1990 end-page: 49 article-title: cDNA cloning reveals the molecular structure of a sperm surface protein PH‐20, involved in sperm‐egg adhesion and the wide distribution of its gene among mammals publication-title: J Cell Biol – volume: 15 start-page: 485 year: 1956 end-page: 91 article-title: The production of capsules, hyaluronic acid and Hyaluronidase to 25 strains of group C streptococci publication-title: J Gen Microbiol – volume: 5 start-page: 54 year: 2003 end-page: 67 article-title: Intra‐articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action publication-title: Arthritis Res Ther – volume: 16 start-page: 1718 year: 2009 end-page: 45 article-title: Role, metabolism, chemical modifications and applications of hyaluronan publication-title: Curr Med Chem – volume: 102 start-page: 212 year: 2002 end-page: 9 article-title: Expression of hyaluronan synthase 2 or Hyaluronidase 1 differentially: affect the growth rate of colon carcinoma cell transplantable tumors publication-title: Int J Cancer – volume: 18 start-page: 280 year: 2008 end-page: 9 article-title: Mouse HYAL3 it encodes a 45–56‐kDa glycoprotein overexpression increases whose hyaluronidase 1 activity in cultured cells publication-title: Glycobiology – volume: 170 start-page: 1086 year: 2007 end-page: 99 article-title: Hyperproduction of hyaluronan in neu‐induced mammary tumor angiogenesis accelerates through stromal cell recruitment: possible involvement of versican/PG‐M publication-title: Am J Pathol – volume: 4 start-page: 873 year: 2012 end-page: 903 article-title: Therapeutic targeting of hyaluronan in the tumor stroma publication-title: Cancers – volume: 85 start-page: 699 year: 2006 end-page: 715 article-title: Hyaluronan fragments: an information‐rich system publication-title: Eur J Cell Biol – volume: 10 start-page: 35 year: 2008 end-page: 42 article-title: The science of hyaluronic acid dermal fillers publication-title: J Cosmet Laser Ther – volume: 23 start-page: 4503 year: 2002 end-page: 13 article-title: Hyaluronic acid hydrogel in the treatment of osteoarthritis publication-title: Biomaterials – volume: 17 start-page: 153 year: 1995 end-page: 6 article-title: Hyaluronan as a drug delivery system for diclofenac: a hypothesis for the mode of action publication-title: Int J Tissue React – volume: 7 start-page: 251 year: 2008 end-page: 8 article-title: New trends in face rejuvenation by hyaluronic acid injections publication-title: J Cosmet Dermatol – start-page: 205 year: 1998 end-page: 17 – volume: 37 start-page: 57 year: 1958 end-page: 64 article-title: Hyaluronate in normal human synovial fluid publication-title: J Clin Invest – volume: 278 start-page: 32259 year: 2003 end-page: 65 article-title: Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44‐expressing tumor cells publication-title: J Biol Chem – volume: 3 start-page: e25597 year: 2013 article-title: Polymer‐conjugated inhibitors of tumor necrosis factor‐ for local control of inflammation publication-title: Biomatter – volume: 8 start-page: 629 year: 1984 end-page: 37 article-title: Effect of oxygen‐derived reactive species on cartilage proteoglycan‐hyaluronate aggregates publication-title: Biochem Int – volume: 2 start-page: 466 year: 2000 end-page: 71 article-title: Hyaluronic acid supplementation publication-title: Curr Rheumatol Rep – volume: 29 start-page: 17 year: 2007 end-page: 25 article-title: Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications publication-title: Biotechnol Lett – volume: 26 start-page: 58 year: 2007 end-page: 68 article-title: Hyaluronan mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways publication-title: Matrix Biol – volume: 65 start-page: 7782 year: 2005 end-page: 9 article-title: HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor publication-title: Cancer Res – volume: 62 start-page: 112 year: 2013 end-page: 20 article-title: Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer publication-title: Gut – volume: 4 start-page: 528 year: 2004 end-page: 39 article-title: Hyaluronan: from the extracellular glue that pericellular cue publication-title: Nat Rev Cancer – volume: 76 start-page: 1753 year: 1954 end-page: 7 article-title: The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord publication-title: J Am Chem Soc – volume: 44 start-page: 1531 year: 2005 end-page: 7 article-title: The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of Individuals living with this condition publication-title: Rheumatology – volume: 117 start-page: 1343 year: 1992 end-page: 50 article-title: Molecular cloning of a novel hyaluronan receptor mediates tumor cell that motility publication-title: J Cell Biol – volume: 273 start-page: 22466 year: 1998 end-page: 70 article-title: HYAL2, and the human gene Expressed in many cells, encodes a lysosomal Hyaluronidase with a novel type of specificity publication-title: J Biol Chem – volume: 107 start-page: 629 year: 1934 end-page: 34 article-title: The polysaccharide of the vitreous humor publication-title: J Biol Chem – volume: 48 start-page: 565 year: 1989 end-page: 70 article-title: Determination of synovial fluid hyaluronate concentration and polymerisation by high performance liquid chromatography publication-title: Ann Rheum Dis – volume: 56 start-page: 10582 year: 2008 end-page: 93 article-title: Absorption, uptake and tissue affinity of high‐molecular‐weight hyaluronan after oral administration in rats and dogs publication-title: J Agric Food Chem – volume: 43 start-page: 155 year: 1995 end-page: 7 article-title: Hyaluronic acid (hyaluronan) in experimental osteoarthritis 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Snippet	Summary Background Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its... Hyaluronic acid is a widely available, biocompatible, polysaccharide with distinguishing physiochemical properties which inspire its application throughout...
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SubjectTerms	adjuvant therapy bioavailability Biological Availability Cosmetic Techniques Dermal Fillers - adverse effects Dermal Fillers - pharmacokinetics Dermal Fillers - therapeutic use Dry Eye Syndromes - drug therapy Humans hyaluronic acid Hyaluronic Acid - adverse effects Hyaluronic Acid - metabolism Hyaluronic Acid - pharmacokinetics Hyaluronic Acid - therapeutic use long-lasting effect Neoplasms - metabolism Osteoarthritis - drug therapy Randomized Controlled Trials as Topic tolerability Viscosupplements - adverse effects Viscosupplements - pharmacokinetics Viscosupplements - therapeutic use wound healing
Title	Physiochemical properties and application of hyaluronic acid: a systematic review
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