Flow-mediated vasodilation as a diagnostic modality for vascular failure

Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is esse...

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Bibliographic Details
Published in:Hypertension research Vol. 31; no. 12; p. 2105
Main Authors: Inoue, Teruo, Matsuoka, Hidehiro, Higashi, Yukihito, Ueda, Shin-Ichiro, Sata, Masataka, Shimada, Ken-Ei, Ishibashi, Yutaka, Node, Koichi
Format: Journal Article
Language:English
Published: England 01.12.2008
Subjects:
Atherosclerosis - diagnosis
Atherosclerosis - diagnostic imaging
Atherosclerosis - physiopathology
Biomarkers - metabolism
Brachial Artery - diagnostic imaging
Brachial Artery - physiology
Endothelium, Vascular - diagnostic imaging
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Humans
Nitric Oxide - metabolism
Regional Blood Flow - physiology
Ultrasonography
Vasodilation - physiology
ISSN:0916-9636
Online Access:Get more information
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Summary:Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is essential in order to appropriately intervene and prevent its progression. Many efforts have been made to assess vascular endothelial function, and one of the most promising methods is the measurement of endothelium-dependent flow-mediated vasodilation (FMD) using high-frequency ultrasonographic imaging and transient occlusion of the brachial artery. The reactive hyperemia caused by the transient brachial arterial occlusion induces the release of local nitric oxide, resulting in vasodilation that can be quantified as an index of vasomotor function. The noninvasive nature of this technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. Although there are technical and interpretive limitations of this technique, FMD-guided therapeutic approaches for vascular failure should contribute to the improvement of cardiovascular mortality and morbidity.
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ISSN:0916-9636
DOI:10.1291/hypres.31.2105