Flow-mediated vasodilation as a diagnostic modality for vascular failure

Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is esse...

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Vydáno v:	Hypertension research Ročník 31; číslo 12; s. 2105
Hlavní autoři:	Inoue, Teruo, Matsuoka, Hidehiro, Higashi, Yukihito, Ueda, Shin-Ichiro, Sata, Masataka, Shimada, Ken-Ei, Ishibashi, Yutaka, Node, Koichi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.12.2008
Témata:	Atherosclerosis - diagnosis Atherosclerosis - diagnostic imaging Atherosclerosis - physiopathology Biomarkers - metabolism Brachial Artery - diagnostic imaging Brachial Artery - physiology Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Nitric Oxide - metabolism Regional Blood Flow - physiology Ultrasonography Vasodilation - physiology
ISSN:	0916-9636
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Abstract	Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is essential in order to appropriately intervene and prevent its progression. Many efforts have been made to assess vascular endothelial function, and one of the most promising methods is the measurement of endothelium-dependent flow-mediated vasodilation (FMD) using high-frequency ultrasonographic imaging and transient occlusion of the brachial artery. The reactive hyperemia caused by the transient brachial arterial occlusion induces the release of local nitric oxide, resulting in vasodilation that can be quantified as an index of vasomotor function. The noninvasive nature of this technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. Although there are technical and interpretive limitations of this technique, FMD-guided therapeutic approaches for vascular failure should contribute to the improvement of cardiovascular mortality and morbidity.
AbstractList	Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is essential in order to appropriately intervene and prevent its progression. Many efforts have been made to assess vascular endothelial function, and one of the most promising methods is the measurement of endothelium-dependent flow-mediated vasodilation (FMD) using high-frequency ultrasonographic imaging and transient occlusion of the brachial artery. The reactive hyperemia caused by the transient brachial arterial occlusion induces the release of local nitric oxide, resulting in vasodilation that can be quantified as an index of vasomotor function. The noninvasive nature of this technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. Although there are technical and interpretive limitations of this technique, FMD-guided therapeutic approaches for vascular failure should contribute to the improvement of cardiovascular mortality and morbidity. Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is essential in order to appropriately intervene and prevent its progression. Many efforts have been made to assess vascular endothelial function, and one of the most promising methods is the measurement of endothelium-dependent flow-mediated vasodilation (FMD) using high-frequency ultrasonographic imaging and transient occlusion of the brachial artery. The reactive hyperemia caused by the transient brachial arterial occlusion induces the release of local nitric oxide, resulting in vasodilation that can be quantified as an index of vasomotor function. The noninvasive nature of this technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. Although there are technical and interpretive limitations of this technique, FMD-guided therapeutic approaches for vascular failure should contribute to the improvement of cardiovascular mortality and morbidity.Vascular endothelial dysfunction represents an initial step of "vascular failure," which we have recently proposed as a comprehensive syndrome of failed vascular functions that extends from risk factors to established atherosclerotic disease. The early detection of vascular failure is essential in order to appropriately intervene and prevent its progression. Many efforts have been made to assess vascular endothelial function, and one of the most promising methods is the measurement of endothelium-dependent flow-mediated vasodilation (FMD) using high-frequency ultrasonographic imaging and transient occlusion of the brachial artery. The reactive hyperemia caused by the transient brachial arterial occlusion induces the release of local nitric oxide, resulting in vasodilation that can be quantified as an index of vasomotor function. The noninvasive nature of this technique allows repeated measurements over time to study the effectiveness of various interventions that may affect vascular health. Although there are technical and interpretive limitations of this technique, FMD-guided therapeutic approaches for vascular failure should contribute to the improvement of cardiovascular mortality and morbidity.
Author	Inoue, Teruo Ueda, Shin-Ichiro Ishibashi, Yutaka Matsuoka, Hidehiro Sata, Masataka Node, Koichi Shimada, Ken-Ei Higashi, Yukihito
Author_xml	– sequence: 1 givenname: Teruo surname: Inoue fullname: Inoue, Teruo email: inouete@med.saga-u.ac.jp organization: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. inouete@med.saga-u.ac.jp – sequence: 2 givenname: Hidehiro surname: Matsuoka fullname: Matsuoka, Hidehiro – sequence: 3 givenname: Yukihito surname: Higashi fullname: Higashi, Yukihito – sequence: 4 givenname: Shin-Ichiro surname: Ueda fullname: Ueda, Shin-Ichiro – sequence: 5 givenname: Masataka surname: Sata fullname: Sata, Masataka – sequence: 6 givenname: Ken-Ei surname: Shimada fullname: Shimada, Ken-Ei – sequence: 7 givenname: Yutaka surname: Ishibashi fullname: Ishibashi, Yutaka – sequence: 8 givenname: Koichi surname: Node fullname: Node, Koichi
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SubjectTerms	Atherosclerosis - diagnosis Atherosclerosis - diagnostic imaging Atherosclerosis - physiopathology Biomarkers - metabolism Brachial Artery - diagnostic imaging Brachial Artery - physiology Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans Nitric Oxide - metabolism Regional Blood Flow - physiology Ultrasonography Vasodilation - physiology
Title	Flow-mediated vasodilation as a diagnostic modality for vascular failure
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