The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model

The objective of this study is to determine growth factor expression and activation of signaling pathways associated with intravitreous neovascularization and peripheral avascular retina using a model of retinopathy of prematurity (ROP) relevant to today with oxygen monitoring in neonatal units. Stu...

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Bibliographic Details
Published in:	Documenta ophthalmologica Vol. 120; no. 1; pp. 25 - 39
Main Author:	Elizabeth Hartnett, M.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.02.2010 Springer Nature B.V
Subjects:	Acetophenones - pharmacology Animals Disease Models, Animal Enzyme Inhibitors - pharmacology Humans Infant, Newborn Medicine Medicine & Public Health NADPH Oxidases - antagonists & inhibitors Ophthalmology Oxidative Stress Oxygen - toxicity Rats Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Retinal Neovascularization - etiology Retinal Neovascularization - metabolism Retinopathy of Prematurity - etiology Retinopathy of Prematurity - metabolism Review Article Vascular Endothelial Growth Factor A - metabolism Vitreous Body - blood supply Oxygen Retinopathy of prematurity Intravitreous neovascularization Vascular endothelial growth factor NADPH oxidase 50/10 OIR model
ISSN:	0012-4486, 1573-2622, 1573-2622
Online Access:	Get full text
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