Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions

The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles. The resulting clock correctly determines the age of mouse cohorts,...

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Veröffentlicht in:Cell metabolism Jg. 25; H. 4; S. 954
Hauptverfasser: Petkovich, Daniel A, Podolskiy, Dmitriy I, Lobanov, Alexei V, Lee, Sang-Goo, Miller, Richard A, Gladyshev, Vadim N
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 04.04.2017
Schlagworte:
Animals
Biological Clocks - genetics
DNA Methylation - genetics
Female
Longevity - genetics
Male
Mice, Inbred C57BL
ISSN:1932-7420, 1932-7420
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Zusammenfassung:The DNA methylation levels of certain CpG sites are thought to reflect the pace of human aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG sites derived from partial blood DNA methylation profiles. The resulting clock correctly determines the age of mouse cohorts, detects the longevity effects of calorie restriction and gene knockouts, and reports rejuvenation of fibroblast-derived iPSCs. The data show that mammalian DNA methylomes are characterized by CpG sites that may represent the organism's biological age. They are scattered across the genome, they are distinct in human and mouse, and their methylation gradually changes with age. The clock derived from these sites represents a biomarker of aging and can be used to determine the biological age of organisms and evaluate interventions that alter the rate of aging.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1932-7420
1932-7420
DOI:10.1016/j.cmet.2017.03.016