Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway

EXs (Exosomes) secreted by mesenchymal stem cells (MSCs) have the potential to treat spinal cord injury (SCI), this study aimed to further explore the therapeutic effect of EXs on SCI. Firstly, EXs were extracted from MSCs and analyzed with a transmission electron microscope. Next, MSCs with or with...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 20; no. 10; pp. 993 - 1009
Main Authors:	Jiang, Zhensong, Zhang, Jianru
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 19.05.2021
Subjects:	Animals Apoptosis - genetics Base Sequence Cell Survival - genetics exosomes Exosomes - metabolism Inflammation - complications Inflammation - genetics Inflammation - pathology Inflammation - physiopathology Male Mesenchymal stem cell Mesenchymal Stem Cells - metabolism MicroRNAs - genetics MicroRNAs - metabolism MIR-145-5P NF-kappa B - metabolism PC12 Cells Rats Rats, Sprague-Dawley Recovery of Function Research Paper Signal Transduction Spinal Cord Injuries - complications Spinal Cord Injuries - genetics Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology spinal cord injury TLR4/NF-κB signaling pathway Toll-Like Receptor 4 - metabolism Mesenchymal stem cell TLR4/NF-κB signaling pathway spinal cord injury MIR-145-5P exosomes
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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