Noncoding RNAs Involved in Mammary Gland Development and Tumorigenesis: There’s a Long Way to Go

The mammalian genome encodes thousands of noncoding RNAs. These noncoding transcripts are broadly categorized into short noncoding RNAs, such as microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) of greater than 200 nt. While the role of miRNAs in development and cancer biology has been extensive...

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Bibliographic Details
Published in:Journal of mammary gland biology and neoplasia Vol. 17; no. 1; pp. 43 - 58
Main Authors: Shore, Amy N., Herschkowitz, Jason I., Rosen, Jeffrey M.
Format: Journal Article
Language:English
Published: New York Springer US 01.03.2012
Springer Nature B.V
Subjects:
Animals
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
Female
Humans
Mammary gland
Mammary Glands, Human - growth & development
Mammary Glands, Human - pathology
Mammary Glands, Human - physiology
Medicine
Medicine & Public Health
miRNA
Non-coding RNA
Oncology
RNA, Untranslated - genetics
Tumorigenesis
Epigenetics
Noncoding RNA
Breast cancer
Alveologenesis
Mammary gland development
ISSN:1083-3021, 1573-7039, 1573-7039
Online Access:Get full text
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Summary:The mammalian genome encodes thousands of noncoding RNAs. These noncoding transcripts are broadly categorized into short noncoding RNAs, such as microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) of greater than 200 nt. While the role of miRNAs in development and cancer biology has been extensively studied, much less is known about the vast majority of noncoding transcripts represented by lncRNAs. LncRNAs are emerging as key regulators of developmental processes and as such, their frequent misregulation in tumorigenesis and disease in not unexpected. The role of lncRNAs in mammary gland development and breast cancer is just beginning to be elucidated. This review will discuss the role of lncRNAs in mammalian and mammary gland development. In addition, we will review the contributions of lncRNAs to the stepwise progression of tumorigenesis, highlighting the role of lncRNAs in breast cancer.
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Amy N. Shore and Jason I. Herschkowitz contributed equally to this work.
ISSN:1083-3021
1573-7039
1573-7039
DOI:10.1007/s10911-012-9247-3