Use of computational fluid dynamics deposition modeling in respiratory drug delivery

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to...

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Vydáno v:Expert opinion on drug delivery Ročník 16; číslo 1; s. 7 - 26
Hlavní autoři: Longest, P. Worth, Bass, Karl, Dutta, Rabijit, Rani, Vijaya, Thomas, Morgan L., El-Achwah, Ahmad, Hindle, Michael
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Taylor & Francis 02.01.2019
Témata:
Administration, Inhalation
aerosol deposition
aerosol dosimetry
Aerosols - administration & dosage
airway models
Asthma - drug therapy
bioequivalence
CFD simulations
complete-airway modeling
Computer Simulation
Drug Compounding
Drug Delivery Systems - methods
Humans
Hydrodynamics
inhalers
Models, Biological
Nebulizers and Vaporizers
Pharmaceutical aerosols
Therapeutic Equivalency
whole-lung CFD modeling
inhalers
whole-lung CFD modeling
aerosol deposition
Pharmaceutical aerosols
complete-airway modeling
airway models
CFD simulations
aerosol dosimetry
bioequivalence
ISSN:1742-5247, 1744-7593, 1744-7593
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Abstract Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies. Expert opinion: Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
AbstractList Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies. Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies. Expert opinion: Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption.INTRODUCTIONRespiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption.This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies.AREAS COVEREDThis review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next-generation of respiratory drug delivery strategies.Complete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.EXPERT OPINIONComplete-airway deposition modeling is a valuable research tool that can improve our understanding of pharmaceutical aerosol delivery and is already supporting medical hypotheses, such as the expected under-treatment of the small airways in asthma. These complete-airway models are also being used to advance next-generation aerosol delivery strategies, like controlled condensational growth. We envision future applications of CFD deposition modeling to reduce the need for human subject testing in developing new devices and formulations, to help establish bioequivalence for the accelerated approval of generic inhalers, and to provide valuable new insights related to drug dissolution and clearance leading to microdosimetry maps of drug absorption.
Author Rani, Vijaya
Dutta, Rabijit
Longest, P. Worth
El-Achwah, Ahmad
Thomas, Morgan L.
Hindle, Michael
Bass, Karl
AuthorAffiliation 1 Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA
2 Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA
AuthorAffiliation_xml – name: 2 Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA
– name: 1 Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, USA
Author_xml – sequence: 1
  givenname: P. Worth
  surname: Longest
  fullname: Longest, P. Worth
  email: pwlongest@vcu.edu
  organization: Department of Pharmaceutics, Virginia Commonwealth University
– sequence: 2
  givenname: Karl
  surname: Bass
  fullname: Bass, Karl
  organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University
– sequence: 3
  givenname: Rabijit
  surname: Dutta
  fullname: Dutta, Rabijit
  organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University
– sequence: 4
  givenname: Vijaya
  surname: Rani
  fullname: Rani, Vijaya
  organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University
– sequence: 5
  givenname: Morgan L.
  surname: Thomas
  fullname: Thomas, Morgan L.
  organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University
– sequence: 6
  givenname: Ahmad
  surname: El-Achwah
  fullname: El-Achwah, Ahmad
  organization: Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University
– sequence: 7
  givenname: Michael
  surname: Hindle
  fullname: Hindle, Michael
  organization: Department of Pharmaceutics, Virginia Commonwealth University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30463458$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords inhalers
whole-lung CFD modeling
aerosol deposition
Pharmaceutical aerosols
complete-airway modeling
airway models
CFD simulations
aerosol dosimetry
bioequivalence
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Snippet Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics...
Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a...
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SubjectTerms Administration, Inhalation
aerosol deposition
aerosol dosimetry
Aerosols - administration & dosage
airway models
Asthma - drug therapy
bioequivalence
CFD simulations
complete-airway modeling
Computer Simulation
Drug Compounding
Drug Delivery Systems - methods
Humans
Hydrodynamics
inhalers
Models, Biological
Nebulizers and Vaporizers
Pharmaceutical aerosols
Therapeutic Equivalency
whole-lung CFD modeling
Title Use of computational fluid dynamics deposition modeling in respiratory drug delivery
URI https://www.tandfonline.com/doi/abs/10.1080/17425247.2019.1551875
https://www.ncbi.nlm.nih.gov/pubmed/30463458
https://www.proquest.com/docview/2179228951
https://pubmed.ncbi.nlm.nih.gov/PMC6529297
Volume 16
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