High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells

Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden. We have investigated the association between memory CD4 and CD8 T cells and levels of neutrali...

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Veröffentlicht in:	Frontiers in immunology Jg. 13; S. 1032911
Hauptverfasser:	Phetsouphanh, Chansavath, Khoo, Weng Hua, Jackson, Katherine, Klemm, Vera, Howe, Annett, Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Stella, Alberto Ospina, Rouet, Romain, Schofield, Peter, Faulks, Megan L., Law, Hannah, Danwilai, Thidarat, Starr, Mitchell, Munier, C. Mee Ling, Christ, Daniel, Singh, Mandeep, Croucher, Peter I., Brilot-Turville, Fabienne, Turville, Stuart, Phan, Tri Giang, Dore, Gregory J., Darley, David, Cunningham, Philip, Matthews, Gail V., Kelleher, Anthony D., Zaunders, John J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 05.12.2022
Schlagworte:	Antibodies, Neutralizing CD4 function CD4 T cells CD4-Positive T-Lymphocytes COVID-19 Epitopes, T-Lymphocyte Humans Immunology neutralizing antibodies proliferation SARS-CoV-2 neutralizing antibodies SARS-CoV-2 CD4 T cells CD4 function proliferation
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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